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Flashcards in Micro Deck (12):
1

mech of tetracycline

inhibits tRNA binding to A site during protein translation

2

mech of erythromycin/clindamycin

block protein elongation (5'-3') in translation

3

mech of streptomycin

binds 30s ribosome changing its conformation and preventing it from binding 50s ribosome and forming the initiation complex for protein translation

4

mech of chloramphenicol

blocks peptidyl transferase from moving AA from A to E site and forming peptide bonds during protein synthesis

5

megaloblastic anemia + high orotic aciduria

orotic acidemua
defect in pyrimidine synthesis
treat with uridine supplementation
defect in orotate phosphoribyl tranferasse and OMP decarboxylase

6

Parkin, Pink-1, DJ 1

mt leading to defect in ubiquitin genes-do not get effective destruction of misfolded proteins and therefore get cytosol accumualtion of bad proteins in the cell

7

aldolase B def

intolerance to fructose
get buildup of fructose 1 phosphate
tx: no fructose

8

pompes disease

alpha glucasidase deificiency
-used in glycogenolysis
hypontia, cardiomyopathy

9

galastosemia

galactose 1 phosphate uridyl transferase deficiency, AR, hepatomegaly, ftt, jaundice, feeding intolerance soon with breastfeeding

10

hereditary fructose intolerance

-aldolase B deficiency
severe life threatening form of fructose intolerance, non functional fructokinase enzyme with inability to metabolize fructose get severe hypoglycemia 20-30min after ingestion of fructose (due to accumulation of fructose 1 phosphate and depletion of inorganic phosphate)

11

PKU

defect in phenylalanine hydroxylase

12

acyclovir

used to treat herpes simplex (+ tzanck) incorporates itself into viral DNA (acyclovir monophos to triphos) and ends Viral DNA synthesis, does not affect nml cells because has much less affiniity and is not phosphrylated as much in normal cells