Micro 4- Pathogenic properties and control mechanisms Flashcards Preview

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Flashcards in Micro 4- Pathogenic properties and control mechanisms Deck (10):
1

what are cytopathic effects? (CPE)

are visible effects of viral infection on a cell

2

list of CPE- pathogenic properties of viruses

-stopping cell synthesis
-causing cell lysosomes to release enzymes
-changing host cell function or inducing chromosomal changes
-inducing antigenic changes on the cell surface
-loss of contact inhibition in the cell, leading to cancer
-producing interferons to protect uninfected cells
-creating inclusion bodies in the cell cytoplasm
-fusing cells to create syncytium

3

3 host defense mechanisms

-interferons
-antibodies
-cell mediated immunity

4

what are interferons?

cytokines produced by lymphocytes and macrophages, have antiviral activity

5

effect of IFN-a and IFN- b

produced in response to viral infections, cause neighboring cells to produce antiviral proteins (AVPs) that interfere with viral replication

6

IFN- y

induces neutrophils and macrophages to kill bacteria

7

antigen-antibody complex forms when

antibodies bind to antigens
-block attachment of viruses to host cells
-cause viruses to agglutinate

8

cell-mediated immunity

-cytotoxic T lymphocytes (CTL) recognizes and kills self-cells altered by infection
-destroys virus-infected and cancer cells

9

vaccination

-provokes a primary immune response
-leads to the formation of antibodies and long-term memory cells
-stimulated memory cells produce a rapid, intense secondary response

10

antimicrobial biocides

-lipid-soluble, most likely effective against envelope virus
-fewer biocides are active against non-enveloped viruses