Microbiology-Viral Bioterroism Agents Flashcards Preview

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Flashcards in Microbiology-Viral Bioterroism Agents Deck (20)
1

What type of viruses are most of the viral hemorrhagic fevers?

RNA

2

Reservoirs of most viral hemorrhagic fevers

Rats, bats for ebola and Marburg. Note that the host usually does not become ill even though humans do.

3

A patient presents with fever, bruising on his arms, muscle aches and GI hemorrhage. What is your differential diagnosis?

VHF (arena, bunya, filo and flaviviruses), Bacterial (typhoid, rickettsioses, leptospirosis, meningococcemia, N. meningitides. E. coli 0157 H7), Protozoa (falciparum malaria) and other (Hemolytic uremic syndrome, vasculitis, heat stroke).

4

Treatment for viral hemorrhagic fever

Limit needle sticks, supportive care, correct coagulopathies, ribavirin (arena and bunyaviruses).

5

Vaccines for VHFs?

Junin (weaponized Argentine hemorrhagic fever) and yellow fever virus.

6

Ebola and Marburg virus types

-ssRNA: needs RNA-dependent RNA polymerase to make mRNA.

7

Bunyavirus transmitted by ticks and humans that causes VHF. What type of virus is it?

Crimean-Congo Hemorrhagic Fever (CCHF). Circular ambisense segmented RNA virus.

8

1/2 of genome is +ssRNA and 1/2 of genome is -ssRNA

Ambisense

9

Arenaviruses transmitted by aerosolized rodent urine/saliva/feces that cause VHF.

Lassa fever and South American Hemorrhagic Fever. Note that Lassa is particularly concerning because there is clear human to human transmission (secretions).

10

How did the arenaviruses get their name?

When they bud from the host cell they bring ribosomes with them and look sandy.

11

Common complications of Lassa virus

3rd trimester abortion and hearing loss

12

Treatment for Lassa virus

Ribavirin

13

A patient presents with fever, chills and multiple joint pain. He spent 5 days in a village in Africa with dead rats around. On day 5 oral, conjunctival and petechial hemorrhages are present. 2 other patients in the ward are affected. What is the likely agent?

Lassa fever virus. 

14

Largest virus there is

Poxvirus (small pox)

15

Small pox features

Complex, dsDNA, resistant to inactivation and replicates in CYTOPLASM.

16

Host of small pox

Human only

17

What distinguishes small pox blisters from any other vesicular lesion?

No region is spared (chicken pox spares hands/feet) and all lesions are at same stage of disease (chicken pox has all at different stages of disease)

18

Key factors that enabled eradication of small pox

No animal reservoir, no recurrent infection, one serotype, effective vaccine, no subclinical infection

19

Treatment for adverse reactions associated with small pox vaccines

hVIG (human Vaccinia Immune Globulin)

20

Absolute contraindication for receiving the small pox vaccine

Eczema