Midterm questions Flashcards
T/F
Ionized compounds (possessing a charge) are lipid soluble and easily pass through body membranes
False
T/F If drug A requires a smaller dose than drug B to produce 50% of the max effect, then drug A is less potent than drug B
False
Stimulation of the PANS, such as when resting and digesting, produces which of the following effects?
- Increased salivation
- Increased BP
- Bronchodilation
- Increased heart rate
- None of the above
Increased salivation
Stimulation of the SANS, such as during a fight or flight situation, poduces which of the following effects?
- Increased salivation
- Increased BP
- Bronchoconstriction
- Decreased heart rate
- None of the above
Increased blood pressure
Which of the following drugs is an angiotensin II receptor antagonist?
- Diovan (valsartan)
- Accupril (quinapril)
- Cardura (doxazosin)
- Calan (verapamil)
- Cardizem (diltiazem)
Diovan (valsartan)
T/F Drugs work by imparting a new function to the host organism, a function that did not exist pior to the administration of the drug
False
T/F Receptors which we target for drug use in the SANS are labeled “adrenergic”
True
T/F Sympathomimetic agents instilled into the eye produce miosis
False
T/F The cardiovascular system fails when the heart and/or blood vessels fail to provide sufficient oxygen to meet the demands of the body
True
The four major steps in the body’s handling of a drug are:
Absorption, distribution, metabolism, excretion
Adverse reactions of cholinergic antagonists include which of the following?
- Xerostomia
- Urinary and GI stasis
- Fever and hyperpyrexia
- Blurred vision and photophobia
- All of the above
All of the above
An infant weighs 10lbs and if the adult dose of something is 30mg, then, according to Clark’s rule, the dosage of the drug for the infant should be:
2mg
Which of the following is false concerning routes of drug administration?
- One disadvantage of IV drug administration is drug irretrievability
- The rectal route is the most convenient way to introduce a drug for systemic effects
- Topical applications are administered to the skin, oral mucosa and also sublingually
- The inhalation route of admission may be used for either local or systemic effects
The rectal route is the most convenient way to introduce a drug for systemic effects
T/F Parasympatholytic agents may also be referred to adrenergic antagonists
False
T/F Cardiovascular disease is complicated by the presence of co-morbid diseases, such as diabetes and hyperlipidemia
True
The letters “q.i.d.” appearing on a prescription indicate that the medication is to be administered:
Four times a day
T/F In first order kinetics, the same percent of drug is eliminated per unit of time
True
T/F Receptors which we target fo drug use in the PANS are labeled “nicotinic chollinergic”
False
In one mechanism by which drugs are metabolized, an inactive parent drug may be transformed into an active compound. This inactive parent drug is called a(n)…..
Metabolite
T/F The mechanism of action of ACE inhibitors involves inhibition of the conversion of angiotensis I to angiotensin II
True
T/F The letters “hs” appearing on a prescription indicate that the medication is to be administered at bedtime
True
The latin phrase “pro re nata” (p.r.n.) means:
As needed
All of the following are ACE inhibitors except:
- Accupril (quinapril)
- Calan (verapamil)
- Capoten (catopril)
- Altace (ramipril)
- Vasotec (enalapril)
Calan (verapamil)
Which of the following would be an expected effect of an alpha-1 agonist?
- Dilation of blood vessels in skin and mucous membranes
- Constriction of blood vessels in skeletal muscle
- Contraction or bronchial smooth muscle
- Relaxation of GI smooth muscle
- None of the above
