misc Flashcards

1
Q

who is crcl usually overestimated in

A

elderly over 65, malnourished, low muscle mass

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2
Q

what p value is stat sig

A

less than 0.05

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3
Q

formula for relative risk

A

it happened to in exp group/total in that group all divided by the same in the control/placebo group

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4
Q

formula for RRR

A

1-RR

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5
Q

formula for absolute risk reduction

A

arithmetic difference between event rates in groups ie control group event rate - exp group event rate. *if increased risk, this is the ARI (NNH is calculated from this)

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6
Q

formula for NNT

A

100/ARR. NNH is same but use ARI (absolute risk increase)

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7
Q

what is the NNH

A

number of patients who would have to be treated for one person to experience an adverse event

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8
Q

what is the NNT

A

number of patients who would have to be treated with the intervention for one to benefit

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9
Q

what does confidence interval indicate

A

precision of estimate- confidence that x% of the values overlap with the true value. Wide CI mean less precise

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10
Q

what does a smaller p value mean

A

less likely result is due to chance

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11
Q

which ace inhibitor’s absorption is decreased by food

A

captopril

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12
Q

when to hold an ace arb unless just volume depletion

A

30% increase in SCr or K over 5.6

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13
Q

can ace and arbs be used in black patients

A

don’t work as well but can be for compelling indications

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14
Q

what is aliskirin

A

direct renin inhibitor

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15
Q

which beta blockers have ISA activity

A

pindolol, acebutalol

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16
Q

which BB need to be adjusted in kidney failure

A

all cardioselective except metoprolol, plus pindolol and nadalol

17
Q

which BB have alpha and beta blockade

A

carvediol, labetalol

18
Q

first line HTN in preg

A

methyldopa

19
Q

name alpha blockers, what are they used for

A

doxazocin, terazocin, prazocin. HTN, pheochromocytoma, prostatism

20
Q

chemo; platinums

A

cisplatin (very emetogenic), carboplatin, oxalyplatinin (cold sensitivity). all can cause nephro and otto***

21
Q

chemo; taxanes

A

used in breast cancer and prostate; paclitaxil, docitaxil., less emetogenic, most arthralgias and myalgias

22
Q

doxorubicin-cancer

A

cardiotoxic

23
Q

bleomycin-cancer

A

lung toxic

24
Q

irenotecan-cancer

A

diarrhea-will use a lot of loperamide

25
Q

nibs+fluorouracil- cancer

A

can cause hand and foot irritation/rash/dryness. avoid tight shoes or callous causing things, good foot care, keep moisturized

26
Q

epithelial growth factor receptor drugs,-cancer

A

cause rash (many nibs, cetuximab)

27
Q

trastuzumab

A

her2drug

28
Q

filgrastim

A

bone pain

29
Q

small molecule kinase inhibitors

A

NIBs (cancer)

30
Q

anthracyclines (rubicins)

A

cardiotoxic

31
Q

nibs, liposomal doxorubicin, flurouracil, capacitabine

A

hand foot skin reactions