Flashcards in Misc Cardiac Deck (11):
List five uses of nitroglycerin and state it's primary use
Angina (primary), CHF, acute MI, pulmonary hypertension, hypertensive emergency
Describe the mechanism of action of nitroglycerin
Nitroglycerin is converted to nitric oxide within vascular smooth muscle eventually resulting in vasodilation of venules and some arterioles
List whether each of the following drugs affect afterload or preload: beta blockers, calcium channel blockers, ace inhibitors, diuretics, nitroglycerin
Beta blocker – Afterload
ace inhibitor – afterload
diuretics – preload
nitroglycerin – preload
How does nitroglycerin decrease the workload on the heart?
Decreased preload from decreased venous return, coronary vasodilation and increased blood flow to coronary arteries
How is nitroglycerin dosed to avoid tolerance-induced inefficacy?
Requires 10 to 12 hour nitrate free interval for regeneration of sulfa hydryl groups
How is nitroglycerin stored?
Stored in glass amber bottles (adheres to plastic, sunlight inactivates, twist off cap for easy open, loses potency after 6 to 12 months)
How is nitroglycerin used in times of angina attacks?
Please tablet/spray under tongue, wait five minutes, if symptoms persist place additional tablet under tongue and go to ER
List the six available forms of nitroglycerin
IV, tabs, aerosol spray, buccal tabs, ointment, transdermal patches
How should transdermal patches be disposed of?
Fold in half before placing into trash
What medication can nitroglycerin not be mixed with?
PDE–5 inhibitors (sildenafil, teldalafil used to treat erectile dysfunction) can cause severe hypotension when mixed with nitrates