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Flashcards in Misc Cardiac Deck (11):

List five uses of nitroglycerin and state it's primary use

Angina (primary), CHF, acute MI, pulmonary hypertension, hypertensive emergency


Describe the mechanism of action of nitroglycerin

Nitroglycerin is converted to nitric oxide within vascular smooth muscle eventually resulting in vasodilation of venules and some arterioles


List whether each of the following drugs affect afterload or preload: beta blockers, calcium channel blockers, ace inhibitors, diuretics, nitroglycerin

Beta blocker – Afterload
CCB– afterload
ace inhibitor – afterload
diuretics – preload
nitroglycerin – preload


How does nitroglycerin decrease the workload on the heart?

Decreased preload from decreased venous return, coronary vasodilation and increased blood flow to coronary arteries


How is nitroglycerin dosed to avoid tolerance-induced inefficacy?

Requires 10 to 12 hour nitrate free interval for regeneration of sulfa hydryl groups


How is nitroglycerin stored?

Stored in glass amber bottles (adheres to plastic, sunlight inactivates, twist off cap for easy open, loses potency after 6 to 12 months)


How is nitroglycerin used in times of angina attacks?

Please tablet/spray under tongue, wait five minutes, if symptoms persist place additional tablet under tongue and go to ER


List the six available forms of nitroglycerin

IV, tabs, aerosol spray, buccal tabs, ointment, transdermal patches


How should transdermal patches be disposed of?

Fold in half before placing into trash


What medication can nitroglycerin not be mixed with?

PDE–5 inhibitors (sildenafil, teldalafil used to treat erectile dysfunction) can cause severe hypotension when mixed with nitrates


What are poppers?

Street drug made of liquid nitroglycerin that gives short buzz, often used during sex