MISSED QUESTIONS Flashcards
(25 cards)
Which of the following IS relevant to the structured vehicle system? (all the apply)
A. Thixotropy
B. Newtonian flow
C. Shear-thinning
D. Plastic flow
E. Dilatant flow
A. Thixotropy
C. Shear-thinning
D. Plastic flow
Which of the following is NOT relevant to the structured vehicle system? (all the apply)
A. Thixotropy
B. Newtonian flow
C. Shear-thinning
D. Plastic flow
E. Dilatant flow
B. Newtonian flow
E. Dilatant flow
When considering a graph of pH vs logk(obs), what does the pH correlating to the lowest “k” indicate?
the pH at which the drug degrades the slowest
When considering a graph of pH vs logk(obs), given that the pH correlating to the lowest “k” is pH 5, what pH do you want to store the drug at? (higher, lower, same pH)
same pH, pH 5
When considering a graph of pH vs logk(obs), given that the pH correlating to the lowest “k” is pH 5, which acid / salt pair is most appropriate?
A. the acid/base pair with a pka < 5
B. the acid/base pair with a pka ~ 5
C. the acid/base pair with a pka > 5
B. the acid/base pair with a pka ~ 5
A pair with a pKa value
closest to the desired pH will have the best buffering capacity
If you are looking to produce a buffer solution of a certain pH & buffering capacity, which acid/base pair should be chosen as the buffer?
A. the acid/base pair with a pka < goal pH
B. the acid/base pair with a pka ~ goal pH
C. the acid/base pair with a pka > goal pH
B. the acid/base pair with a pka ~ goal pH
If you are looking to produce a buffer solution of a certain pH & buffering capacity, how do you determine the correct concentrations of acid & salt to achieve the goal buffering capacity?
the Van Skyle equation
B = 2.3 C * (Ka*[H3O+]) / (Ka + [H3O+])^2
Ka = 10^ -pka
[H3O+] = 10^ -pH
The following ingredients stabilize an emulsion product by reducing interfacial tension or forming a steric barrier around the dispersed droplets. Which of the following stabilizes the emulsion by the SAME mechanism?
A. Bentonite
B. Sodium lauryl sulfate
C. Magnesium aluminum silicate
D. Aluminum hydroxide
E. Charcoal
A. Bentonite
C. Magnesium aluminum silicate
D. Aluminum hydroxide
E. Charcoal
sodium lauryl sulfate is a SURFACTANT, the others are FINE PARTICLES
Which section of the federal food, drug & cosmetic act allows local pharmacies to prepare compounded sterile preparations (CSPs)?
NONE !
CSPs are regulated via USP 797
Define “LVP”
Single dose injections packaged in a container containing more than 100 mL
Which ISO class is relevant to air quality in LAFW?
ISO Class 100
ISO Class 5
ISO Class 5 !!
List types of central access devices
PICC (peripherally inserted central catheter)
Hickman
Broviac
Vascular access port (VAP)
CVC (central vein catheters)
Consider a suspension of sulfadiazine (density = 1.5 g/mL) with an average diameter of 26 μm.
If you reduce sulfadiazine particle size to 2.6 μm by spray drying and use water as a vehicle, will the suspension settle QUCKLY or be DELAYED?
sedimentation will be delayed to a certain extent
Consider a suspension of sulfadiazine (density = 1.5 g/mL) with an average diameter of 26 μm.
If you add methylcellulose to increase viscosity of water to 200 cps, will the suspension settle QUCKLY or be DELAYED?
sedimentation will be delayed to a certain extent
Consider a suspension of sulfadiazine (density = 1.5 g/mL) with an average diameter of 26 μm.
If you reduce particle size to 10 μm by jet milling and increase water viscosity to 100 cps, will the suspension settle QUCKLY or be DELAYED?
sedimentation will be delayed to a certain extent
Consider a suspension of sulfadiazine (density = 1.5 g/mL) with an average diameter of 26 μm.
If you replace water with sorbitol solution (density: 1.3 g/mL, viscosity: 110 cps), will the suspension settle QUCKLY or be DELAYED?
sedimentation will be delayed to a certain extent
Consider a suspension of sulfadiazine (density = 1.5 g/mL) with an average diameter of 26 μm.
If you add diluted bentonite magma to form floccules, will the suspension settle QUCKLY or be DELAYED?
Floccules will settle fast (but can be resuspended easily by shaking)
Consider the relationship between [KH2PO4] added to the suspension vs. the sediment volume of the suspension. What describe the non-caking zone the best?
A. The suspension turned to a dispersed suspension.
B. H2 PO4- neutralized the surface charge of dispersed particles.
C. The dominant interparticle force is repulsive force.
D. The suspension does not settle.
E. The suspension forms cloudy supernatant when settled.
B. H2PO4- neutralized the surface charge of dispersed particles.
USP 797 (Pharmaceutical Compounding-Sterile Preparations) describes the standards to be followed to minimize harm, including death, to human and animal patients that could result from the following. What are the NOT risks unique to parenteral preparations?
A. Microbial contamination
B. Excessive bacterial endotoxins
C. Variability from the intended strength of correct ingredients
D. Physical and chemical incompatibilities
E. Chemical and physical contaminants
F. Use of ingredients of inappropriate quality
C. Variability from the intended strength of correct ingredients
D. Physical and chemical incompatibilities
E. Chemical and physical contaminants
F. Use of ingredients of inappropriate quality
USP 797 (Pharmaceutical Compounding-Sterile Preparations) describes the standards to be followed to minimize harm, including death, to human and animal patients that could result from the following. What are the NOT risks unique to parenteral preparations?
A. Microbial contamination
B. Excessive bacterial endotoxins
C. Variability from the intended strength of correct ingredients
D. Physical and chemical incompatibilities
E. Chemical and physical contaminants
F. Use of ingredients of inappropriate quality
A. Microbial contamination
B. Excessive bacterial endotoxins
Are LVPs single or multiple dose injections?
single dose injections
What is the correct volume for LVPs?
> 100 mL
ou have a solution of Ceftriaoxane Sodium dissolved in SWFI, containing the equivalent to 1 g of Ceftrioxane in a total volume of 20 mL. What amount of glycerol do you need to add to the solution in order to obtain an osmolarity value of 280 mOsmol/L? (Ignore volume increase due to glycerol. Round up the answer to the nearest whole number).
Ceftriaoxane MW = 554.48
Glycerol MW = 92.09
Sodium atomic weight = 22.98
Answer: 184 mg
Osmolarity of Ceftriaxone 1 g/20 mL = 1g/20 mL * 1000 mL/1L * 1 mol/554.48 g * 1 Osmol/1 mol * 1000 mOsmol/1 Osmol = 90.17 mOsmol/L
As Ceftriaxone sodium (ionizes to ceftriaxone- + sodium+), 90.17 mOsmol/L ceftriaxone + 90.17 mOsmol/L sodium = 180.35 mOsmol/L
Need 280-180.35 = 99.65 mOsmol/L as glycerol
X g/20 mL * 1000 mL/1L * 1 mol/92.09g * 1 Osmol/1 mol * 1000 mOsmol/1 Osmol = 99.65
mOsmol/L
X = 0.1835 g = 183.5 mg
Inclisiran, a therapeutic siRNA used to lower cholesterol levels, is modified with a trivalent
GalNAc ligand at the 3’ end. What is the purpose of the GalNAc ligand?
A. To allow for room temperature storage of the siRNA
B. To enable binding of the siRNA to the mRNA of the PCSK9 enzyme
C. To enhance protein production
D. To enable entry into the nucleus
E. To target the liver
E. To target the liver
