Flashcards in Mitochondrial genetics Deck (9)
What percentage of our cell volume consists of mito?
The ox phos ETC comes from what kind of DNA?
Mitochondrial AND nuclear genes
What happens if nuclear and mitochondrial genes don't perfectly align the parts of the ETC?
Leak of reactive oxygen species (ROS) and then apoptosis
The majority of the mitochondrial genome codes for what?
Does mitochondrial DNA pack with histones like nuclear DNA?
Which are subject to higher mutation rates: nuclear or mitochondrial genes?
What is an exception to this?
Mitochondrial except for ETC-coding genes in nuclear DNA
What is a common system that is negatively affected by mitochondrial diseases?
Why do mitochondrial diseases inherit differently?
- random segregation of mitochondria during duplication and cell division
- there is often a threshold above which a disease becomes symptomatic based on the ratio of good:bad mito acquired