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Flashcards in Mitochondrial genetics Deck (9)
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1

What percentage of our cell volume consists of mito?

22%

2

The ox phos ETC comes from what kind of DNA?

Mitochondrial AND nuclear genes

3

What happens if nuclear and mitochondrial genes don't perfectly align the parts of the ETC?

Leak of reactive oxygen species (ROS) and then apoptosis

4

The majority of the mitochondrial genome codes for what?

Proteins

5

Does mitochondrial DNA pack with histones like nuclear DNA?

No

6

Which are subject to higher mutation rates: nuclear or mitochondrial genes?

What is an exception to this?

Mitochondrial except for ETC-coding genes in nuclear DNA

7

What is a common system that is negatively affected by mitochondrial diseases?

CNS

8

Why do mitochondrial diseases inherit differently?

Heteroplasmic inheritance

- random segregation of mitochondria during duplication and cell division

- there is often a threshold above which a disease becomes symptomatic based on the ratio of good:bad mito acquired

9

How are mitochondria inherited (mostly)?

Maternally. Vast majority come from oocyte.