mod 3 v2

Question 1

Barbiturie Action: Long

Answer 1

Seizures/epilepsy (oral)

Question 2

Barbiturie Action: Short, Ultra-Short

Answer 2

Anesthesia (intravenous)

Question 3

Barbiturie Mechanism of Action

Answer 3

Receptor activated —> duration of chloride channel opening increases

Question 4

Alcohol Withdrawl Treament

Answer 4

Benzodiazepine

Question 5

Alcohol AUD Treatment

Answer 5

Naltrexone

Question 6

Alcohol Mechanism of Action

Answer 6

Bind to Cl channel & increase GABA mediated neuronal inhibition

*diff GABA bidning site

Question 7

Short Term alcohol effects

Answer 7

CNS: Disinhibtion
Cardiovascular: Vasodilation
GI: Gastic Secretion
Liver: ALcoholic Liver Disease

Question 8

Long Term Alcohol Effects

Answer 8

CNS: alcoholic dementia
Cardiovascular: Alcoholic cardiomyopathy
Liver: Alcoholic liver disease

Question 9

Alcohol Use Dirorder Treamtnet

Answer 9

Benzodiazepines, Naltrexone

Question 10

Cannnabis Mechanism of Action

Answer 10

THC binds to CB1 receptors in the brain and spinal cord.
CB1 activation inhibits neurotransmitter release, leading to CNS depression

Question 11

THC 1/2 life

Answer 11

30 hrs

Question 12

Marihiuana medical use

Answer 12

Nausea from chemo

Question 13

CB1

Answer 13

-Found in brain
-Cognitive alterations

Question 14

CB2

Answer 14

-perphery
-immunosuppressive qualities

Question 15

Cannabis Short Term Effects

Answer 15

CNS: Euphoria, increased appetite
Cardiovascular: increase ahret rate, hypotension
GI Tract: dry mouth
Other: reduced sex drive, disrupted ovarian cycle

Question 16

Cannabis Misuse

Answer 16

LOW

Question 17

:

Cannabis Tolerance

Answer 17

Develops to THC’s psychoactive, cardiovascular, and cognitive effects

Question 18

Cannabis long term effects

Answer 18

memory loss
poor concentration
impaired motor coordination
amoticational syndrome

Question 19

Opioids classes

Answer 19

-endogenous
-natural
-semi-syntehtic
-synthetic

Question 20

Endogenous Opioids (produced in body)

Answer 20

3 families: enkephalins, dynorphins, and beta-endorphins

Question 21

Natural Opioids (derived from Opium Poppy)

Answer 21

Morphine
Codeine
(-10x, covert to mrophien via liver enzymes)

Question 22

Semi-Synthetic Opioids (Modified Morphine Compounds)

Answer 22

Hydromorphone:
5x
Used for severe pain relief (analgesia)

Diacetylmorphine (Heroin)
2-5x
OUD treatment

Question 23

Synthetic Opioids (Fully Synthetic, Not derived from Morphine)

Answer 23

Fentanyl:
100x

Loperamide:
Treats common side effects of opioids (constipation)
Used over the counter for diarrhea

Methadone:
Prevents withdrawal symptoms

Question 25

Delta (δ) Receptors:

Answer 25

Found in brain & spinal cord Modulate emotional response to opioids

Question 27

opioids mechiansm of action

Answer 27

Block pain pathways in the brain and spinal cord (via activation of mu opioid receptors) Reduce neurotransmitter release from presynaptic neurons, preventing pain signals (postsynaptic neurons effects Reduce emotional reaction to pain via modulation of limbic system

Question 29

Opioid Treament

Answer 29

1. Buprenorphine/Naloxone (block mu opioid receptors --> precent withdrawl) 2. Methadone

Question 30

Opioid Effects

Answer 30

Analgesia Sedation Cough suprresion respiratory depression Constripation Reduced release of sex hormones miosis (pupil constriction)