MOD 9

Question 1

are amines basic or acidic?

Answer 1

basic

Question 2

arrange in DECREASING basicity

1. aniline
2. alkyl amines
3. NH3

Answer 2

alkyl amines > NH3 > aniline

*alkyl amines most basic since R groups stabilize the (+) of the amine

Question 3

effect of electron-releasing groups in basicity of amines?

effect of electron-withdrawing groups in basicity of amines?

Answer 3

1. increase basic strength
   - increase in electron density in Nitrogen Lone Pair
2. decrease basic strength
   - decrease in electron density in Nitrogen Lone Pair

Question 4

determine if basicity will increase / decrease

• more R groups?

Answer 4

increase basicity

Question 5

arrange in DECREASING basicity

1. 2 phenyl rings
2. cyclohexylamine
3. 1 phenyl ring (aniline)

Answer 5

cyclohexylamine > 1 phenyl ring (aniline) > 2 phenyl rings

Question 6

PREPARATION OF AMINES

Alkylation of Amines

Answer 6

adding alkyl group only

1st reagent: SN2
2nd reagent: NaOH

ammonia -> primary
primary amine -> secondary
secondary -> tertiary

NH3 + H3CH2C-Cl

-> H2N-CH2CH3

*kung anong attached sa reagent with X atom, yun ang kakabit sa N

Question 7

amino acids with LESS THAN 50 units are building blocks for?

Answer 7

peptides

Question 8

amino acids with MORE THAN 50 units are building blocks for?

Answer 8

proteins

Question 9

determine the term

difunctional compounds containing both BASIC AMINO & ACIDIC CARBOXYL GROUP

Answer 9

amino acids

Question 10

test to differentiate primary, secondary, and tertiary amines

Answer 10

Hinsberg test

Question 11

ph indicator

acidic: reddish
basic: yellow
neutrl: orange

Answer 11

Azo Compound

Question 12

the most common amino acids are?

Answer 12

alpha-amino acids

Question 13

what do u call amino group attached to alpha carbon?

how bout the R group attached to the alpha carbon?

Answer 13

alpha-amino group

side chain (confers the identity of amino acid)

Question 14

6 alkyl amino acids?

Answer 14

1. Glycine (G) - gly
2. Alanine (A) - ala
3. Valine (V) - val
4. Proline (P) - pro
5. Leucine (L) - leu
6. Isoleucine (I) - ile

Question 15

2 sulfur-containing amino acids?

Answer 15

1. Cysteine (C) - cys
2. Methionine (M) - met

Question 16

2 alcohol amino acids?

Answer 16

1. Serine (S) - ser
2. Thereonine (T) - thr

Question 17

2 acid amino acids?

Answer 17

1. Aspartic Acid (D) - asp
2. Glutamic Acid (E) - glu

Question 18

2 amide amino acids?

Answer 18

1. Asparagine (N) - asn
2. Glutamine (Q) - gln

Question 19

3 base amino acids?

Answer 19

1. Lysine (K) - lys
2. Arginine (R) - arg
3. Histidine (H) - his

Question 20

3 aromatic amino acids?

Answer 20

1. Phenylalanine (F) - phe
2. Tyrosine (Y) - tyr
3. Tryptophan (W) - trp

Question 21

which among the 20 standard amino acids has 2 chiral centers?

Answer 21

isoleucine

and

threonine

Question 22

amino acids are predominantly _____ or _____

Answer 22

• dipolar
• zwitterion

Question 23

are amino acids chiral?

+ 2 pairs of enantiomers?

+ which is naturally occurring?

Answer 23

yes EXCEPT GLYCINE

D: right side NH3
L: left side NH3 (naturally occurring)

Question 24

peptide bonds are amide bonds formed by ??

Answer 24

CONDENSATION REACTION

with liberation of H2O

Question 25

amino acid chains with MW <10000 Da

Answer 25

polypeptides

Question 26

amino acid chains with MW ≥ 10000 dA

Answer 26

proteins

Question 27

amino acid that assumes 3d arrangement

Answer 27

protein