module 16 non-insulin meds Flashcards Preview

Pharmacology > module 16 non-insulin meds > Flashcards

Flashcards in module 16 non-insulin meds Deck (21)
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1
Q

sulfonylurea meds

A

glyburide
glipizide
glimeperide

2
Q

sulfonylurea MOA

A

stimulate pancreatic insulin secretion
block ATP-sensitive K channels
-> depolarization -> Ca influx -> insulin release

3
Q

sufonylurea admin

A

hepatically metabolized

- parent and active metabolite renally excreted

4
Q

sulvonylurea AE

A

hypoglycemia

wt gain

5
Q

sulfonylurea EDU

A

moderate-high A1C reducation: >1%
- good efficacy: short lived (combo therapy)
renal dysfunction/elderly: glipizide is drug of choice: short half life.

6
Q

meglitinides meds

A

nateglinide

repaglinide

7
Q

meglitinide MOA

A

stimulates pancreatic insulin secretion

8
Q

meglitinide AE

A

hypoglycemia

wt gain

9
Q

meglitinide admin

A

rapid oral absorption
short half life
- freq. dosing
- with meals

10
Q

DDP-4 inhibitors meds

A

alogliptan
linagliptan
saxagliptan
sitagliptan

11
Q

DDP-4 inhibitors MOA

A

inc. incretin action
- > inc. glucose dependent insulin release
- > dec. post-prandial glucagon release

12
Q

DDP-4 nml activity

A

inactivates incretin

13
Q

DDP-4 inhibitor AE

A

URI
nasopharyngitis
low risk hypoglycemia
rare: pancreatitis

14
Q

DDP-4 inhbitor precaution

A

dose adjustment with renal impairment

15
Q

DDP-4 inhibitor DI

A

3A4: saxagliptan, linagliptan

16
Q

DDP-4 inhibitor EDU

A

modest A1C reduction: less than 1%

weight neutral

17
Q

GLP-1 agonist meds

A
gulaglutide
exenatide
liraglutide
lixisenatide
semaglutide
18
Q

GLP-1 agonist MOA

A

inc. incretin action
- activate GLP-1 Rc: inc. insulin, dec. glucagon
resistant to metabolism by DPP-4

19
Q

GLP-1 agonist AE

A

nausea
diarrhea
rare: pancreatitis
low risk hypoglycemia

20
Q

GLP-1 agonist admin

A

subQ

21
Q

GLP-1 agonist EDU

A
cardiovascular benefits
wt. loss
- slows gastric emptying
- dec. appetite
moderate A1C reduction: ~1%

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