module 3 SNRI, atypical antiD, serotonin receptor agonist

Question 1

SNRI drugs

Answer 1

venlafaxine

duloxetine

Question 2

SNRI MOA

Answer 2

block NE and 5HT reuptake

- venlafaxine: concentration dependent

Question 3

SNRI use

Answer 3

depression

- duloxetine: also neuropathic pain

Question 4

SNRI contraindication

Answer 4

HTN

Question 5

duloxetine interactions

Answer 5

CYP2D6, 1A2

Question 6

venlafaxine prodrug

Answer 6

desvenlafaxine active form

Question 7

bupropion MOA

Answer 7

atypical antidepressant

inhibit dopamine and NE reuptake

Question 8

bupropion AE

Answer 8

insomnia

least sexual side effects

Question 9

bupropion contraindications

Answer 9

seizure disorder

eating disorder

Question 10

bupropion administration

Answer 10

IR:TID
SR: BID
XL: daily

Question 11

mirtazapine MOA

Answer 11

atypical antidepressant
antagonizes 5HT2/3 and a2 adrenergic receptors
antagonizes histamine

Question 12

mirtazapine AE

Answer 12

inc. appetite
sedation
less sexual dysfunction

Question 13

mirtazapine interactions

Answer 13

CYP3A4

Question 14

Nefazodone MOA

Answer 14

atypical antidepressant
inhibits 5HT transporter
antagonize:
-5HT2
- Histamine
- A1

Question 15

nefazodone use

Answer 15

depression
anti-anxiety
- 2nd or 3rd line drug

Question 16

nefazodone AE

Answer 16

sedation
orthostasis
hepatotoxicity
fulminant liver failure
less sexual dysfunction

Question 17

nefazodone contra

Answer 17

liver dysfunction

Question 18

nefazodone interaction

Answer 18

CYP3A4

Question 19

trazodone MOA

Answer 19

atypical antidepressant
inhibit 5HT transporter 
antagonize: 
- 5HT2
- histamine
- A1

Question 20

trazodone AE

Answer 20

priapism

Question 21

trazodone use

Answer 21

high dose: antidepressant

low dose: sleep agent

Question 22

trazodone interactions

Answer 22

CYP3A4

Question 23

buspirone MOA

Answer 23

serotonin receptor agonist
- 5HT1A
nonsedating
nonaddictive

Question 24

buspirone use

Answer 24

anxiety

Question 25

buspirone AE

Answer 25

dizzy | nausea

Question 26

drugs that inc. neurotransmission without known MOA

Answer 26

ampthetamine methamphetamine methylphenidate modafinil armodafinil - may interfere with synaptic vesicle storage - may displace 5HT, NE, DA from vesicles and reuptake 2nd line

Question 27

unknown MOA drugs AE

Answer 27

induction os psychosis and alertness | - use: narcolepsy

Question 28

lithium MOA

Answer 28

interfere with cAMP and IP3 formation

Question 29

lithium use

Answer 29

bipolar | - mania and depression control

Question 30

lithium AE

Answer 30

``` nausea thirst polyuria hypothyroidism tremor weakness confusion teratogenesis ```

Question 31

lithium contra

Answer 31

narrow TI preg renal insufficiency - secreted and reabsorbed in renal tubules

Question 32

lithium interactions

Answer 32

diuretics | probenecide

Question 33

lithium monitoring

Answer 33

therapeutic levels: 07-1.2.

Question 34

lithium administration

Answer 34

long half life: 12-27hrs

Question 35

Mood stabilizers for bipolar disorder

Answer 35

carbamazepine | valproic acid