MODULE 5 PART 2.1: ROLE OF NEUTROPHILS IN INFLAMMATION

Question 1

(1) Briefly, after tissue damage, the neutrophils roll along the endothelial surface where a glycoprotein called ____ in expressed.

Answer 1

P-selectin

Question 2

(2) P-selectin then bind to the ___ on passing neutrophils.

Answer 2

L-selectin

Question 3

(3) The rolling neutrophils will come to a stop and adhere on the endothelial surface of the blood vessel after activation of neutrophils by ____ secreted by endothelial cells.

Answer 3

PAF

Question 4

(4) The leukocyte-endothelial cell adhesion is further developed and mediated by _____ and _____.

Answer 4

cytokines; chemokines

Question 5

(5) The cytokines and chemokines then function to ?

Answer 5

• Attract more neutrophils
• Enhance neutrophil adhesion
• Promote vasodilation
• Procoagulant activity
• Thrombosis
• Expression of chemotactic molecules

Question 6

(6) In addition, there are also cell surface proteins that make cell stick together such as _____.

Answer 6

integrins

Question 7

(7) After adhesion to blood vessels, there will be the _____ of the neutrophils into the surrounding tissues. Thus they are the first cells to arrive at damaged tissues.

Answer 7

emigration

Question 8

(8) The neutrophils will do its function of ____ in the site of microbial invasion and inflammation.

Answer 8

phagocytosis

Question 9

(9) Once they phagocytize, the dying neutrophils, which are then called the _____, will release chemotactic factors such as _____ and _____ to attract macrophages.

Answer 9

“martyrs of immune system”; elastase and collagenase