MODULE 5 PART 2.3: ROLE OF MACROPHAGES IN INFLAMMATION Flashcards
(13 cards)
Monocytes bind to endothelial cells when there is tissue damage. They emigrate into the cell tissues and becomes _____ in response to attractants.
macrophages
What are the following products that can attract macrophage?
- Products of complement activation
- Bacterial products
- Molecules released from damaged cells
Once in the site of invasion or inflammation, the macrophages will contribute its role on _____.
phagocytosis
Macrophage, unlike neutrophils, can undertake sustained, repeated phagocytic activity. True or False?
True
Macrophages restrict its role into phagocytosis only. True or False?
False, they also have a role in the removal of dead and dying cells
Microbial products trigger macrophages to synthesize inducible ____ ____ ____ which uses NADPH and oxygen to produce large amount of ____ ____.
- nitric oxide synthase
- nitric oxide (NO)
Nitric oxide is highly toxic. True or False?
False
Nitric oxide reacts to superoxide anion to produce ?
Peroxynitrite and nitrogen dioxide radical
What are peroxynitrite and nitrogen dioxide radical?
Highly reactive and toxic oxidants
All macrophages can produce nitric oxide. True or False?
False
A population of macrophage that defend against microbial invaders and produce proinflammatory cytokines.
M1 cells
A population of macrophage that reduces inflammation and produce cytokines that tend to suppress immune responses.
M2 cells
A population of macrophage that plays a key role in wound healing by promoting blood vessel formation, tissue remodeling and tissue repair.
M2 cells
