MODULE 4 PART 2: INTERLEUKINS Flashcards
(34 cards)
Key role in fever, hematopoiesis, appetite control, bone metabolism, and acquired immunity
Interleukin 1
Induces the production of prostaglandin
Interleukin 1
Activates helper and cytotoxic T cells and NK cells, but in order to be responsive to ____, antigen and IL-12 must first activate T cells and induce expression of both ____ and its receptor.
Interleukin 2
Triggers the T cell to proliferate and stimulates the proliferation and cytotoxicity of Th1 cells
Interleukin 2
- Stimulates the growth and maturation of the bone marrow stem cells for eosinophils, neutrophils, and monocytes
- Activates eosinophils; promotes macrophage cytotoxicity and phagocytosis
- Promotes immunoglobulin secretion by cells
Interleukin 3
- Acts on B cells, T cells, macrophages, endothelial cells, fibroblast, and mast cells
- Stimulates the growth and differentiation of B cells
- Major importance in the development of allergic reactions by inducing B cells to switch to IgE production
Interleukin 4
Interleukin 4 enhances the development of cytotoxic T cells from resting T cells and make helper T cells grown in absence of _____.
IL-2
In humans, it controls the eosinophil production by stimulating growth and differentiation of eosinophil precursors in the bone marrow.
Interleukin 5
In mice, it enhances B cell growth
Interleukin 5
Produced by muscle cells during exercise
Interleukin 6
Acts on T cells, B cells, hepatocytes, and bone marrow stromal cells
Interleukin 6
Interleukin 6 promotes _____ production and T cell differentiation.
Interleukin 2
Interleukin 6 synergizes with _____ to promote Th2 cell differentiation.
Interleukin 4
Interleukin 6 acts as cofactor with ____ in IgM synthesis and with ____ in IgA synthesis.
Interleukin 1; Interleukin 5
- Required for the final maturation of B cells into plasma cells
- A major stimulator of the acute-phase response
Interleukin 6
- Regulates the activity of lymphoid stem cells
- Major role is to control lymphocyte function
- Necessary for lymphocytes to produce functioning antigen receptors
Interleukin 7
- A stem cell growth factor produced only by Th2 cells
- Promotes the growth of helper T cells and mast cells
- Contribute to the development of allergic diseases
Interleukin 9
An immunosuppressive and anti-inflammatory cytokine that regulates inflammation as well as T cell, NK cells, and macrophage function
Interleukin 10
Interleukin 11 stimulates B cell growth in association with _____.
Interleukin 6
Interleukin 11 stimulates megakaryocyte colony formation in association with _____ and promotes the production of acute-phase proteins.
Interleukin 3
Produced by monocytes, macrophages, dendritic cells, B cells, and keratinocytes
Interleukin 12
Produced by bone marrow stromal cells, epithelial cells, and fibroblasts
Interleukin 11
Interleukin 12 promotes Th1 activity by inducing secretion of ____ and ____ and enhances T and NK cells proliferation and cytoxicity.
Interleukin 2; Interferon Y
Interleukin 12 synergizes with ____ in promoting IFN-y production.
TNF-a
