Module 6: Clinical Genetics Overveiw

Question 1

What are the 4 common practice areas in clinical genetics?

Answer 1

• Preimplantation & Prenatal Genetics
• Pediatric Genetics
• Cancer Genetics
• Adult Genetics

Question 2

Preimplantation and Prenatal Genetics

Answer 2

-Has to do w/ pregnancies & planning for pregnancies

Question 3

Prenatal Screening and Diagnosis

Answer 3

• Used for ongoing pregnancies

- Screening/Testing of a fetus for a genetic condition

Question 4

How do healthcare providers get Prenatal Diagnosis?

Answer 4

• Chorionic Villus Sampling (CVS)

- Amniocentesis

Question 5

Pediatric Genetics

Answer 5

After child is born - can start at newborn

Question 6

(T/F) All cancer is genetic

Answer 6

True

Question 7

Sporadic Cancer

Answer 7

Mutations can give certain cells a modest growth advantage over normal cells

Question 8

What is the Two-Hit Theory of Cancer Causation

Answer 8

• This is one explanation of early onset & increased incidence of people w/ a germline mutation
• Each cell starts w/ 2 normal chromosomes
• Those w/ a hereditary susceptibility for cancer have 1 mutated chromosome
• They only need 1 “hit” of an environmental factor to have cancer - whereas others need 2