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IMM005 > Molecules of the immune system > Flashcards

Molecules of the immune system Flashcards

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1
Q

Cells expressing CD3

A

All T cells

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2
Q

Cells expressing CD2

A

T cells

NK cells

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3
Q

Cells expressing CD4

A

T helper cells

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4
Q

Cells expressing CD8

A

Cytotoxic T cells

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5
Q

Role of CD14

A

Act as receptor for LPS

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6
Q

Cells expressing CD15

A

NK cells

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7
Q

Cells expressing CD19 and CD20

A

B cells

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8
Q

Cells expressing CD25

A

Tregs

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9
Q

Role of CD25

A

Receptor for IL-2

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10
Q

Cells expressing CD56

A

NK cells

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11
Q

Cells expressing CD58

A

APCs

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12
Q

Role of CD58

A

Binds to CD2

Stimulates T cells

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13
Q

Cells expressing CD40

A

APCs

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14
Q

Cells expressing CD40L

A

Th cells

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15
Q

Role of CD40L

A

Reacts with APCs

Stimulates APCs to produce more costimulatory molecules and IL-12

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16
Q

Cells expressing CD28

A

T cells

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17
Q

Cells expressing CD80/86

A

APCs

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18
Q

Cells expressing CTLA4

A

T cells

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19
Q

Cells expressing PD1

A

T cells

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20
Q

CD molecules expressed by all T cells

A

CD3

CD28

CTLA4

PD1

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21
Q

CD molecules expressed by NK cells

A

CD2

CD15

CD56

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22
Q

CD molecules expressed by APCs

A

CD56

CD40

CD80/86

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23
Q

Role of interferons in the immune system

A

Inhibit viral invasion through upregulating expression of molecules that inhibit viral proliferation

Downregulates Th2 activity

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24
Q

Which cells express IFN?

A

Th1

NK

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25
Cells expressing IL-1
Monocytes Macrophages DCs
26
Role of IL-1
Inflammatory Induces changes in the vascular endothelium to facilitate leukocyte entry
27
Role of IL-6
Inflammatory Induces changes to vascular endothelium to facilitate leukocyte entry
28
Role of IL-8
Inflammatory
29
Inflammatory interleukins
IL-1 IL-6 IL-8
30
Cell secreting IL-2
T cells
31
Role of IL-2
Stimulates T and B cell proliferation Production of memory and effector T cells
32
Cell secreting IL-3
Th2
33
Role of IL-3
Stimulates the differentiation of stem cells down the myeloid path
34
Role of IL-4
Stimulates Th2 differentiation Class-switches B cells to IgE
35
Cells secreting IL-4
Th2
36
Cells secreting IL-5
Th2
37
Role of IL-5
Recruits and activates eosinophils
38
Role of IL-7
Promotes the differentiation into the lymphoid path Stimulates the proliferation of all lymphoid lineage cells
39
Role of IL-9
Drives mast cell recruitment
40
Cells secreting IL-9
Th2
41
Cells secreting IL-10
Monocytes Th2 Treg
42
Role of IL-10
Anti-inflammatory Stimulates B cell proliferation
43
Cells secreting IL-12
DCs Macrophaes Neutrophils
44
Role of IL-12
Stimulates differentiation of Th1 ENhances cytotoxic activity of CD8 and NK cells
45
Cells secreting IL-13
Th2
46
Role of IL-13
Induces epithelial cell proliferation and stimulates mucus production Hinders parasite colonisation of the epithelium
47
Cells secreting IL-17
Th17
48
Role of IL-17
Pro-inflammatory
49
Role of IL-21
Proliferation Differentiation of antibody producing plasma B cells
50
Cells secreting TNFa
Cytotoxic lymphocytes
51
Role of TNFa
Inflammatory cytokine Induces changes in the vascular endothelium to facilitate leukocyte entry into the inflammatory site
52
Role of TGFb
Immunosuppressant
53
Cells secreting TGFb
Tregs
54
Complement carrying out mast cell degranulation
C3a | C4a
55
Complement carrying out opsonisation
C3b C4b C5b
56
Complement carrying out chemotaxis
C5a
57
Complement forming the MAC
C5b C6-C9
58
Role of IgA
Primary defense against local infections Abundance in saliva, tears, bronchial secretions and prosatic fluids
59
Role of IgG
Produced in later stages of infection Persists for life after infection
60
Role of IgD
Along with IgM, the only antibody found bound to the cell membrane Found on naive B cells
61
Role of IgM
Produced in primary response to infection Multiple arms increase avidity
62
Role of IgE
Key mediator in allergies

IMM005 (17 decks)

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