Morphine and ASA Drug Profiles

Question 1

Morphine Sulfate - Pharmacology and Actions

Answer 1

• Narcotic analgesic.
• Alleviates pain by acting on the pain receptors in the brain, elevates pain threshold.
• CNS depressant - depresses brainstem respiratory centers.
• Increases venous pooling, vasodilates arterioles, reducing preload and afterload.
• Histamine release.

Question 2

Morphine - Indications

Answer 2

Analgesia

Question 3

Aspirin -
Pharmacology & Actions

Answer 3

-Aspirin inhibits prostaglandin and disrupts platelet function
-Mild analgesic and anti-inflammatory

Question 4

Morphine - Absolute Contraindications

Answer 4

• Respiratory and/or CNS depression.
• Hypotension
• Morphine sulfate allergy.

Question 5

Aspirin - Indications

Answer 5

Adult Patient with suspected Acute Coronary Syndrome

Question 6

Aspirin - Absolute Contraindications

Answer 6

• Active GI Bleed
• Pt has already taken 324mg in last 24 hrs
• Allergy to Aspirin

Question 7

Aspirin - Precautions & Side Effects

Answer 7

• May cause GI discomfort and Nausea
• May cause Wheezing

Question 8

Morphine - Precautions and side effects

Answer 8

• Morphine causes neurologic and respiratory depression. Respiratory depression may be worse in patients with underlying lung disease or concomitant use of other depressant drugs such as benzodiazapines or alcohol.
• Morphine can be reversed with naloxone.
• Check and document vital signs and patient response after each dose.
• When morphine is given to treat pain, the goal is reduction of pain not total elimination of pain.

Question 9

Morphine - Administration, onset, peak effect, duration

Answer 9

• IV
• Onset: 30 seconds
• Peak Effect: 20 minutss
• Duration: 2-4 hours

Question 10

Aspirin - Administration
(Route, Onset, Peak, Duration)

Answer 10

• Oral
• 5-30min Onset
• 1-2hr Peak Effect
• 4-6hr Duration