Mostly renal, some IBS and masses Flashcards
1
Q
Right iliac fossa masses (GI tract)
A
Appendix mass/abscess, Intussusception, caecal carcinoma, Crohn’s disease.
2
Q
Right iliac fossa masses - likely systems involved.
A
GI tract or urogenital.
3
Q
Right iliac fossa masses (urogenital)
A
Transplanted kidneys, kidney malformation, tumour in an undescended testis.
4
Q
Right iliac fossa masses (random, not GI or urogenital)
A
Amoebic abscess, actinomycosis, TB mass, pelvic mass.
5
Q
Abdominal distension causes
A
The five Fs: Flatus Fat Fluid Faeces Fetus
6
Q
Causes of just ascites (no portal hypertension)
A
Malignancy Pancreatitus Low albumin Myxodema (hypothyroidism) CCF pericarditis Infections like TB.
7
Q
Causes of ascites with portal hypertension.
A
Cirrhosis, portal nodes, Budd-Chiari syndrome, IVC or portal vein thrombosis.
8
Q
Left upper quadrant masses - probable organs affected
A
Spleen, stomach, kidney, colon, pancreas
9
Q
Faeculent vomit
A
Suggests low intestinal obstruction or the presence of a gastrocolic fistula.
10
Q
With abdominal pain check
A
1) Site, intensity, character, duration and frequency.
2) Aggravating and relieving factors.
3) Any associated symptoms.
11
Q
Causes of right hypochondrial pain
A
Gall bladder or biliary tract. More rarely can be hepatic congestion or peptic ulcer disease.
12
Q
Acute pancreatitis definition
A
Inflammation of the pancreatic gland initiated by acute injury on a background of a previously normal pancreas.
13
Q
Acute pancreatitis: presenting symptoms
A
Epigastric pain accompanied by nausea and vomiting, with involvement of retroperitoneum leading to back pain.
14
Q
Acute pancreatitis: non-presenting symptoms.
A
Widespread tenderness in abdomen with guarding. Reduced or absent bowel sounds.
15
Q
Acute pancreatitis: investigations.
A
Blood tests showing raised serum and/or raised urinary amylase.
16
Q
Acute pancreatitis predisposing factors.
A
Alcoholism (more in men), gallstones (more in women).
17
Q
Odynophagia
A
Pain on swallowing, commonly due to mouth ulcers
18
Q
How to identify heartburn as non-cardiac
A
Burning sensation, not crushing, upwards radiation, occurs on lying down or bending forward.
19
Q
Deep and poorly localised midline pain is caused by…
A
Distension of hollow organs, mesenteric traction or excessive smooth muscle contraction. Pain is conducted by sympathetic splanchnic nerves.
20
Q
Epigastric pain arises from
A
Stomach, liver, spleen and biliary system
21
Q
Umbilical pain arises from
A
Small bowl and appendix.
22
Q
Suprapubic pain arises from
A
The colon, although this can be localised.
23
Q
Midline pain radiating to the back
A
Likely to be pancreatic
24
Q
Main parts of kidney
A
hilum, renal cortex, renal medulla. Pyramids and columns.
25
Layers of tissue around kidney
Perinephric fat, renal fascia, paranephric fat.
26
Anatomy of left renal vein
It passes between the abdominal aorta and the superior mesenteric artery, and can be compressed by an aneurysm in either.
27
Constrictions of the ureter
ureteropelvic junction,
crossing the common iliac vessels,
entering the bladder
28
Urinary tract stones - age, sex and predisposition
More men than women, tends to be in 20-60 yr olds, a sedentary lifestyle is predisposing.
29
What is a urinary tract stone.
A polycrystalline aggregate of precipitated soluble salts in the urinary tract.
30
Urinary tract imaging
Abdominal X-ray can show stones.
US scanning (for dilatations)
IV urogram
CT.
31
Types of renal tumours
```
More common: renal cell carcinoma (can have venous extension) - 90%.
Less common (5%): transitional cell tumours.
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32
Common renal diagnostic tests
Clearance tests
Concentration and dilution tests
Serum creatinine and BUN
Protein in urine
33
Symptoms and causes of acute renal failure
Symptoms: elevated serum creatinine. Renal function declined over days to weeks.
Causes: pre-renal > renal > post renal.
34
Pre-renal causes of acute kidney failure.
Hypotension, volume depletion, sepsis and renovascular disease.
35
Symptoms of chronic kidney disease.
Increased urea and creatinine, increased phosphate and decreased haemoglobin.
36
Common causes of chronic kidney disease
Diabetes mellitus, hypertensive nephropathy, obstructive uropathy, chronic primary glomerulonephritis.
37
Complications of nephrotic syndrome
Loss of proteins leads to increased risk of infection and thromboembolism. Also have hypercholestraemia.
38
Symptoms of nephritic syndrome
Hypertension, haematuria and acute renal failure (oliguria).
Also fluid retention, uraemia, and proteinuria.
39
Nephrotic syndrome - symptoms and most common cause.
Symptoms: proteinuria of at least 3g/24hr, hypoalbuminaemia, oedema. Hypercholesteraemia.
Most common cause is membranous glomerulonephritis.
40
Effects of treatment of membranous glomerulonephritis.
1/3 recover with conservative treatment, 1/3 don't, and 1/3 get worse.
41
Pre-renal causes of kidney failure
Rapid drop in blood pressure.
42
Renal causes of kidney failure.
Increase in blood pressure, diabetes.
43
Post-renal causes of kidney failure
Obstruction (stones or malignancy).
Retroperitoneal fibrosis.
Malignancy outside urinary tract causing pressure and obstruction.
44
The functional unit of the kidney
The nephron. There are roughly 10 to the 6 in each kidney.
45
Normal urine output
About 0.5 ml/kg/hr
46
Position of kidney
10-12 cm long between T12 and L3. Right kidney is lower.
47
Parts of the nephron
The corpuscle and the tubule
48
Parts of the renal corpuscle
Glomerulus (with 3 membranes)
| Bowman's capsule.
49
Parts of the renal tubule
Proximal tubule
Loop of Henle
Distal tubule
Collecting duct
50
Parts of the Loop of Henle (in kidney)
Thin descending limb
Thin ascending limb
Thick ascending limb.
51
Role of distal tubule in kidney
Hormone sensitive water balance.
52
Parts of the juxta-glomerular apparatus
Granular cells secreting renin, the macula densa alter GFR and renin secretion.
53
Stimulation and effect of renin
Decrease in Na+ filtered, or decrease in afferent arteriole pressure or sympathetic B receptor stimulation all lead to renin secretion.
Renin catalyses conversion of angiotensinogen to angiotensin I (which is converted to angiotensin II, a vasoconstrictor).
54
Stimulation of erythropoietin secretion
Hypoxia of the inner cortex and peritubular interstitium and polycystic kidney disease increase production.
Chronic renal failure decreases production.
55
Role of ADH
Short acting increase in water reabsorption in the distal tubule and collecting duct. Decreased ADH leads to diabetes insipidus. Increased can be due to a pituitary tumour.
56
IBS def
A relapsing functional bowel disorder in which abdominal pain or discomfort is associated with defecation or a change in bowel habit.
57
IBS epidemiology
10-20% of population of UK. More common in women.
| Peak prevalence between ages of 20-30.
58
IBS aetiology
Seems to involve abnormal smooth muscle activity, visceral hypersensitivity and abnormal central pain processing.
59
IBS clinical presentation
```
Pain or discomfort.
1/3 have constipation
1/3 have diarrhoea
1/3 have both hard and soft stools.
Chronic with remissions. Urgent morning rush common.
```
60
IBS investigations
Bloods
Coeliac screen
CA-125 for women at risk of ovarian cancer
Faecal calprotectin for those who could have IBD.
61
IBS management
Diet (limit/increase high-fibre) + fluids.
| Placebo effect strong
62
Clinical features of peptic ulcer disease
Epigastric pain, bloating, fullness, heartburn.
63
Clinical features of peptic ulcer disease - duodenal ulcers
Epigastric pain before meals or at night, relieved by milk
| bloating, fullness, heartburn.
64
ALARM Signs for peptic ulcer disease
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Anaemia
Loss of weight
Anorexia
Recent onset/progressive course
Melaena/haemoptysis
Swallowing difficulties.
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65
With a patient with peptic ulcer disease, who is under 55 yr, what investigation do you do?
Test for H. pylori
66
With a patient with peptic ulcer disease, new onset over 55yr or with ALARM Signs, what investigation do you do?
Endoscopy
67
Treatment of peptic ulcer disease
Lifestyle modifications
H. pylori triple therapy
PPIs (or H2 blockers, sometimes)
Stop drugs causing ulcers.
68
Complications of peptic ulcer disease
Bleeding, perforation, malignancy
69
Tenesmus
A feeling of incomplete emptying after defecation
70
Questions to ask about diarrhoea
```
Acute or chronic? Watery?
Blood?
Mucus?
Frank pus?
Explosive?
Pain?
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71
Causes of diarrhoea with blood
Infections
Amoebiasis
UC, Crohn's, cancer
Various colitides
72
Causes of diarrhoea with mucus
IBS, cancer, polyps
73
Causes of diarrhoea with frank pus
IBD, diverticulitis, fistula
74
Causes of explosive diarrhoea
Mostly infections
75
Management of acute abdomen
Take basic obs to triage
History
Analgesia
Investigate
76
Basic investigations for acute abdomen
Bloods - FBC, U&Es, CRP.
MSU and blood cultures
Stool tests, plain radiology, special tests.
77
Urolithiasis - epidemiology, hereditary factors, acquired factors.
5-10% of population. More men than women.
Hereditary factors include cystinuria, primary hyperoxaluria
Acquired factors include hypercalcaemia, hypercalciuria, sarcoidosis, gout and leukaemia.
4 types of stone
78
Types of urinary tract stones
70% calcium oxalate/phosphate
15% struvite stones
5-10% uric acid
1-5% cysteine.
79
Features of calcium oxalate kidney stones
White, hard, radiopaque. Calcium phosphate often causes staghorn in renal pelvis, calcium oxalate is generally present in the ureter.
80
Features of struvite stones
Usually in proteus or staphylococci infection.
81
How do you identify what type of kidney stone the patient has?
Either analyse stone, or do
Serum calcium and uric acid analysis
Urnialysis (volume, calcium, oxalates and cysteine levels)
Urine pH – more than 8 means probably UTI.
82
Conditions causing high conc of metabolic products in glomerular filtrate
Low urinary volume due to fluid restriction (increase fluids).
Increased fluid loss.
Increased excretion of metabolic products forming stones.
High plasma volume leading to high filtrate level.
Low tubular reabsorption from the filtrate.
83
What values define hypercalciuria?
In men more than 7.5 mmols/day
| In women more than 6.2 mmols/day.
84
What is hyperoxaluria a risk factor
It causes formation of calcium oxalates without hypercalciuria.
85
What causes hyperoxaluria
Diet rich in oxalates (restrict diet) or increase absorption in fat malabsorption. Or can be primary.
86
Conditions predisposing to stone formation (4)
High conc of metabolic products in glomerular filtrate
Changes in urine pH
Urinary stagnation
Deficiency of stone forming inhibitors in urine.
87
What causes changes to urine pH
Diet and infection. Affects preciptation of salts.
88
What causes urinary stagnation
Obstruction of urinary flow
89
What are stone forming inhibitors in the urine?
Citrate, pyrophosphate and glycoproteins
90
What is acute pyelonephritis?
Suppurative inflammation of the kidney, commonly caused by E. Coli
91
What parts of the kidney are involved in acute pyelonephritis and how?
Neutrophils within the tubules and interstitium, glomeruli only involved in severe candida disease.
Yellow white cortical abscesses with surrounding hyperaemia.
92
What are complication of acute pyelonephritis?
scarring. Complications include pyonephritis, when the pelvis, calyces and ureter fill with pus, peri-nephric abscess and papillary necrosis.
93
Causes of acute pyelonephritis - acronym
POST CARDS
94
Causes of acute pyelonephritis - POST CARDS
```
Pyelonephritis
Obstruction of urogenital tract
Sickle cell disease
Tuberculosis
Chronic liver disease
Analgesia or alcohol abuse
Renal transplant rejection
Diabetes mellitus
Systemic vasculitis.
```
95
How do you treat acute pyelonephritis?
Commonly caused by E. Coli, s while awaiting blood cultures, treat with ciprofloxacin for 7 days.
96
Epidemiology for cholelithiasis
Gallstones. 10-20% of adult populations, with higher prevalence in some Native American tribes. Pigment stones common in non-Western populations.
97
Risk factors for cholestrol stones
```
Age
Female sex hormones
Obesity
Rapid weight loss
Genetic abnormalities
Hyperlipidaemia
```
98
Risk factors for pigment stones
Chronic haemolytic syndromes,
Biliary infection
Ileal disease
Cystic fibrosis with pancreatic insufficiency.
99
Imaging for gallstones
If no symptoms, or simply pain, then use US.
If worried about pancreatitis or peritonitis then use CT
Use MRCP if suspected biliary duct stone.
100
Pathogenesis of gallstones
```
An imbalance in bile composition rendering the chloesterol and calcium salts insoluble - this can be caused by cholesterol supersaturation in bile (hepatic cholesterol hypersecretion), crystal nucleation (mucin hypersecretion aids this),
stone growth (gall bladder hypermobility)
```
101
Acute tubular necrosis - causes
Ischaemic (hypotension, hypovolaemia, NSAIDs potentiate ischaemia by inhibiting prostaglandins)
Toxic (nephrotoxic drugs)
102
Systemic diseases causing glomerular lesions - classes
Immune complex mediated
Metabolic
Vasculitis
103
Immune complex mediated causes of glomerular lesions
SLE
Henoch-Schonlein
Bacterial endocarditis
Goodpasture's
104
SLE damage to kidneys and treatment
Minimal change to diffuse proliferative GN
Immune complex deposition leads to basement membrane and endothelial thickening.
Treat with immunosuppression
105
What is Henoch-Schonlein purpura?
A immune mediated vasculitis mainly in kids affecting the skin (purpuric rash), joints (pain), intestine (pain, vomiting) and kidneys (GN)
106
What effects can bacterial endocarditis have on the kidneys?
Antibody deposition and emboli can cause infarction
107
What are the antibodies against in Goodpasture's syndrome?
Anti-basement membrane antibodies - affects lungs and kidneys.
108
What are metabolic causes of glomerular damage?
Diabetic glomerulosclerosis.
109
Which vasculitides commonly cause glomerular damage?
Microscopic polyarteritis nodosa (necrotising)
| Wegener's (rare, necrotising, affects U and L resp tract and kidneys)
110
Causes of damage to tubules and calyces
Infection, some drugs (NSAIDs, penecillin, rifampicin), urate nephropathy, chronic hypercalcaemia, multiple myeloma.
111
How what mediates the damage to the tubules and calyces causes by certain drugs (penecillin, rifampicin)
T-cell mediated inflamation
112
What causes urate nephropathy?
Increased synthesis in psoriasis or malignancy
| Decreased clearance in CRF (which can lead to gout)
113
How does hypercalcaemia lead to tubule damage?
By accumulating calcium in the cells and by stone formation.
114
How does multiple myeloma cause kidney damage?
By Bence-Jones proteins whose light chains lead to inflammation,
Paraproteins,
Urate deposition,
Hypercalcaemia.
115
What are the hereditary glomerular diseases?
Alport's and Fabry's
116
What is Alport's disease?
An X-linked collagen abnormality causing glomerulonephritis, ocular abnormalities and hearing loss.
117
What is Fabry's disease?
A glycolipid disorder leading to cardiac issue and glomerulonephritis.
118
Infective causes of glomerulonephritides.
Post-streptococcal (after tonsil, pharynx or skin infection) or non-strep.
119
Results of infective GN
proteinuria, haematuria, low GFR
120
Type of GN caused commonly by infection
Diffuse and proliferative.
121
What is vesico-ureteric reflux associated with?
Reflux nephropathy
122
What is the result of reflux nephropathy?
Increased ureteric pressure leads to scarring, deformation and dilated calyces, and formation of eosinophilic casts.
123
What are the common benign causes of kidney tumours?
Renal fibroma and cortical adenoma - which looks like RCC histologically.
124
Renal cell carcinoma presentation
Haematuria, paraneoplastic syndromes
125
Renal cell carcinoma common paraneoplastic syndromes
PTH leads to hypercalcaemia
ACTH leads to Cushing's syndrome
EPO leads to polycythaemia
Renin leads to htn.
126
Spread of renal cell carcinoma
Via direct invasion, via lymph to lumbar nodes,
127
Treatment of renal cell carcinoma
Nephrectomy with radiotherapy.
128
Common kidney malignancy in children
Wilm's tumour.
129
Where do the kidney lymph nodes drain?
To the para-aortic lymph nodes.
130
Polycystic disease definition
Autosomal dominant condition involving PKD1, 2 or 3, leading to the formation of of multiple cysts and impairment of renal function.
131
When and how does polycystic disease present?
In the 30-40s wiht htn, loin pain, haematura and large palpable kidneys.
Kidney failure 40-60s.
132
What is polycystic kidney disease associated with?
SAH or cerebral haemorrhage.
133
How does htn affect renal vessels?
Leads to hyperplasia and hyalinisation of the arteriole wall called benign nephrosclerosis and hence ischaemic atrophy of the nephrons.
134
What effect does accelerated htn have on the kidney?
It causes petechial haemorrhages and fibrin deposits (leading to fibrinoid necrosis) which lead to severe arterial damage, proteinuria, haematuria and renal failure.
135
What are the thrombotic microangiopathies leading to renal damage? And what is the triad of symptoms they cause?
HUS and TTP.
| Haemolysis, thrombocytopenia, ARF.
136
Histologically what kind glomerulonephritis is acute post-infective GN?
All cells involved, so diffuse proliferative.
137
What causes rapidly progressive GN?
SLE, Wegener's granulomatosis and microscopic polyangiitis - epithelial cell proliferate causing cresent formation.
138
Which group of patients are mostly likely to have minimal change GN?
Children.
139
What are the common causes of membranous GN?
Subepithelial immune complex deposition and basement membrane tumours. Usually idiopathic.
140
What are the types of membranoproliferative GN?
Usually primary causes. Type 1 is due to immune complexes, type 2 due to complement.
141
What are the causes of focal segmental glomerulosclerosis?
Heroin use, AIDS, reaction to chronic proteinuria, idiopathic.
142
IgA nephropathy presentations
young male, recurrent episodes of macroscopic haematuria
typically associated with mucosal infections e.g., URTI
nephrotic range proteinuria is rare
renal failure
