MPGS

Question 1

what is the presentation associated with MPGN ?

Answer 1

can present with nephritic or nephrotic

Question 2

what are the types of MPGN and what are the associated pathologies ?

Answer 2

type 1 - associated with HBV and HBC infection
type 2 - associated with C3 nephritic factor , persistant complement activation , hypocomplementemia

Question 3

what is the appearance of MPGN on light microscopy ?

Answer 3

mesangial ingrowth
GBM splitting
tram track on HE and PAS stain

Question 4

what is the immuno appearance of MPGN ?

Answer 4

granular

Question 5

what is the appearance on electron microscopy with MPGN ?

Answer 5

type 1 - subendothelial deposits IgG antibodies
type 2 - intramembranous deposits

Question 6

what is the other name given for the findings associated with type 2 MPGN on electron microscopy ?

Answer 6

dense deposit disease

Question 7

what is the effect of C3 convertase ?

Answer 7

activates complement in the alternative pathway
this leads to hypocomplimentemia