MPGS Flashcards

(7 cards)

1
Q

what is the presentation associated with MPGN ?

A

can present with nephritic or nephrotic

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2
Q

what are the types of MPGN and what are the associated pathologies ?

A

type 1 - associated with HBV and HBC infection
type 2 - associated with C3 nephritic factor , persistant complement activation , hypocomplementemia

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3
Q

what is the appearance of MPGN on light microscopy ?

A

mesangial ingrowth
GBM splitting
tram track on HE and PAS stain

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4
Q

what is the immuno appearance of MPGN ?

A

granular

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5
Q

what is the appearance on electron microscopy with MPGN ?

A

type 1 - subendothelial deposits IgG antibodies
type 2 - intramembranous deposits

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6
Q

what is the other name given for the findings associated with type 2 MPGN on electron microscopy ?

A

dense deposit disease

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7
Q

what is the effect of C3 convertase ?

A

activates complement in the alternative pathway
this leads to hypocomplimentemia

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