MSK Flashcards Preview

Clinical Pathology > MSK > Flashcards

Flashcards in MSK Deck (30):
1

Summary of MSK Pathology

Infections - Osteomyelitis, Septic Arthritis

Arthritis - OA, RA, Gout, Septic, Psoriasis

Paget's D
HPT
Renal osteodystrophy
Bone mets
Muscle D

2

Osteomyelitis is bone infection that can occur by haematogenous spread, contigous-focus or direct innoculation. What are the corresponding classifications?

Type 1: MEDULLARY (Haematogenous)

Type 2: SUPERFICIAL (Contigous-spread)

Type 3: LOCALISED (direct innoculation e.g. trauma)

Type 4: DIFFUSE

3

Presentation of osteomyelitis?

Pain (noctural)
Reduced movement
+/- B symptoms
+/- 4 cardinal signs

4

~60% of Osteomyleitis cases are caused by...?

S. Aureas

(Strep, Enterococci, salmonella, TB, Brucella)

5

Bone biopsy would be taken to establise the cause of osteomyelitis. What is the treatment if caused by S. Aureas, gram -ve, Enterococci?

Flucloxicillin

Ciprofloxacin

Vancomycin

6

Define Septic Arthritis.

= inflamm of joint space from infection

7

What are the two types of septic arthritis?

Native joint infection
Prosthetic joint infection

8

Most common cause of Septic Arthritis?

S. Aureas

9

Pre-disposing factors in Native joint infection?

RA
Trauma
Immunocompromised
IVDU

(haematogenous, trauma)

10

Which septic joint infection typically presents as 4 cardinal signs + reduced movement + (B symptoms)

Prosthetic joint infection

11

How would you investigate septic arthritis?

Joint aspirate
Crystal examination
WCC
Culture

12

Treatment for prosthetic joint infection is more complicated and longer than native. What is it?

Drain pus/fluid
Flucloxicillin + Rifampicin

13

Arthritis = pain/stiffness in joint. Most common cause is...?

INFLAMMATION

14

Acute Arthritis presents with 4 cardinal signs. T/F?

T

15

Chronic Arthritis examples are...?

RA
OA

16

What is the most common joint disease?

Common sites?

Osteoarthritis

Often hands/knee/hips

17

Which arthritis is caused by progressive erosion of articular cartilage?

What can precipitate this?

OA

Degeneration
Over-use
Diabetes
Obesity

18

RA = autoimmune destruction of articular cartilage --> ankylosing joints. How does it present?

1st - malaise, fatigue, general MSK
4 cardinal signs (esp small joints)

Still in morn/after activity

19

Which Arthritis has systemic manifestations (inflamm) and more common in females?

RA

20

Gout = uric acid desposition in which 2 sites?

Joints --> Arthritis, tophi
Kidney --> Gouty nephropathy --> UA stones

21

Bone tumours can arise from bone and cartilsge. Malignant tumours are seen in which ae group?

Young

22

Bone mets commonly go to which organs?

Breast
Thyroid
Prostate
Kidney
GI

23

Define Polymyalgia Rheumatica.

(immunological)

= conn tissue disorder causing stiffness/weakness/pain in neck/upper limb

24

Polymyalgia Rheumatica is associated with what condition?

Giant Cell Arteritis

25

What mode of inheritance is Duchenne Muscular Dystrophy?

X-linked

(hypertrophy of functioning muscle)

26

The presenting complaint of this disorder is muscle weakness..

MG

= autoimmune blocking AChR in NMJ

27

Dermatomyosistis classicaaly presents as..?

Peri-orbital odema
Scaly facial rash

28

Progressive degeneration of motor neurones?

MND

29

Eaton-Lambert syndrome is a metastatic manifestation of cancer. T/F?

F

Non-met manifestation

30

The condition in which damaged skeletal muscle breaksdown rapidly + can lead to renal failure.

Rhabdomyolysis