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Flashcards in MSK pharmacology Deck (18):
1

Non-selectibe COX inhibitors

Aspirin
Ibuprofen
Indomethacin

2

Indomethacin is used mainly for

gout because it blocks urate crystal phagocytosis and ankylosing spondylitis`

3

COX-2 inhibitors

Celecoxib
Etoricoxib
Meloxicam

4

COX-2 don't have an impact on this important COX-1 mediated process

no impact on Platelet aggregation

5

Acetaminophen is an anti-pyretic but not an

anti-inflammatory. It has central/direct analgesic effects

6

a DMARD that inhibits secondary PMN chemotaxis is

Methotrexate used for RA

7

A DMARD used to inhibit IL-1, IL-2-R production

Cyclosporine

8

Anti-TNF biologics

Etanercept, Infliximab, Adalimumab

9

B cell depleting biologic

Rituximab

10

short duration steroids

hydrocortisone
cortisone
prednisone

11

intermediate duration steroids

triamcinalone

12

long acting steroids

dexamethasone

13

What treatment of gout inhibits microtubule aggregation which thereby disrupts leukocyte chemotaxis and phagocytosis

Colchicine

14

Why is indomethacin given for gout?

It blocks urate crystal phagocytosis

15

What drug reduced urate productio by blocking the conversion of xanthine to uric acid

Allopurinol

16

What class of drugs increases the renal clearance of uric acid

Uricosuric drugs

17

What class is Probenacil and what does it do?

Uricosuric drug that inhibits tubular reabsorption of or uric acid thereby increasing the renal clearance of uric acid

18

What's an example of a true opioid?

Morphine
Codeine