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Histopath & MTLE > MTAP (Introduction) > Flashcards

MTAP (Introduction) Flashcards

1
Q

Retention time of Records such as Requisition, Quality Control, and Instrument maintenance

A

2 years

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2
Q

Retention time of clinical pathology lab reports

A

2 years

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3
Q

Retention time of surgical pathology reports

A

10 years

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4
Q

Retention time of autopsy forensic reports

A

indefinitely

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5
Q

Retention time of cytogenetics reports

A

20 years

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5
Q

Retention time of bone marrow slides?

A

7 days

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6
Q

Retention time of cytogenetics slides

A

3 years

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6
Q

Retention time of pathology blocks

A

10 years

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7
Q

When accepting papers (2-3 papers) that contain information for the sample from OR they must include details such as:

A
  • name of patient
  • purpose of the surgery
  • type of surgery
  • type of tumor (if applicable)
  • types of sutures
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8
Q

TAT of surgical pathology and cytology

A

5-7 days

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9
Q

TAT of PAP smear

A
  • 3 days
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9
Q

TAT of frozen section

A
  • 24 hours
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10
Q

Retention time of specimen

A

3 months

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11
Q

Retention time of tissue blocks

A

10 years

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12
Q

These are not diagnostic but only a guide in order to give initial diagnosis

A

Tumor markers

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12
Q

Retention time of slides

A

5-7 years

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13
Q

Sometimes mimic tumor marker, also the reason why TM is not diagnostic

A

Proteins

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14
Q

Criteria for malignancy

A

Chromatin in tissue

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15
Q

Tumor Marker associated with liver cancer and germ cell tumor

A

Alpha-fetoprotein (AFP)

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15
Q

Tumor Marker associated with ovarian cancer

A

CA-125

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16
Q

Tumor Marker associated with colorectal cancer

A

Carcinoembryonic antigen (CEA)

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16
Q

Tumor Marker associated with pancreatic, gallbladder, bile duct, and gastric cancers

A

CA19-9

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16
Q

Tumor Markers associated with breast cancer

A
  • CA15-3/CA27.29
  • Estrogen receptor (ER)/ progesterone receptor (PR)
16
Q

Tumor Marker associated with B-cell lymphomas and leukemias

16
Tumor Marker associated with acute myeloid leukemia
CD33
17
Tumor Marker associated with chronic lymphocytic leukemia
Chromosome 17p deletion
17
Tumor Marker associated with non-hodgkin lymphoma
CD20
17
Tumor Marker associated with metastatic prostate cancer
Prostatic Acid Phosphatase (PAP)
18
Tumor Marker associated with colorectal cancer and non-small cell lung cancer
KRAS gene mutation
19
Acid Formaldehyde Hematin is removed by?
- Saturated alcoholic pictrate acid - 1% alcoholic KOH - Kardasewitsch MTDS - Lillies's MTDS
20
Tumor Marker associated with ovarian and breast cancers
BRCA1 and BRCA2 gene mutations
21
Tumor Marker associated with lymphomas and leukemias
BCL2 gene rearrangment
22
A healthy, relaxed, sedentary 70kg man who is killed instantly in an accident will usually have organs such as lungs, heart, liver, adrenals, thyroid, spleen, and brain weight in these ranges:
- Right Lung: 300-400 gm - Left Lung: 250-350 gm - Heart: 250-300 gm - Liver: 1100-1600 gm - Adrenals: 4 gm or so each - Thyroid: 10-50 gm - Spleen: 60-300 gm - Brain: 1150-1450 gm
23
Appears as brown or black granules that may obscure micro details
Acid Formaldehyde Hematin
24
Appears as black granular deposits
Mercuric Chloride
25
Mercuric Chloride is removed by?
Alcoholic Iodine
26
Appears as black precipitate
Osmium tetroxide
27
Osmium tetroxide is removed by?
Cold water
28
A fine-yellow brown deposit
Chromate
29
Chromate is removed by?
Acid alcohol
30
Cheapest among blocks and pellets
Paraffin wax
31
Susbtitute for paraffin wax matter in the?
melting point (MP)
32
- Mixture of highly puried paraffin and synthetic plastic polymers - It is more elastic and resilient than paraffin wax thereby permitting large dense tissue blocks such as bones and brain to be cut easily with the same result as in double embedding
Paraplast
33
MP of Paraplast
56-57C
34
- Soluble in common clearing agents and follows the same time schedule for paraffin impregnation - Does not tend to crack like other paraffin wax substitutes
Paraplast
35
A semisynthetic wax recommended for embedding EYES
Bioloid
36
A synthetic wax substitute similar to Paraplast and is less brittle and less compressible than Paraplast
Embeddol
37
MP of Embeddol
56-58C
38
Clearing agents used for Ester wax
Cellosolve (ethylene glycol monoethyl ether) or xylene if indicated
39
A product of paraffin, containing RUBBER, with the same property as paraplast
Tissue mat
40
Its MP is around 46-48C, harder than paraffin, and is not soluble in water, but is soluble in 95% Ethyl Alc and other clearing agents
Ester wax
41
Has a MP 38-42C and are plastic polymers, mostly polyethylene glycols
Water-soluble waxes
42
Soluble and miscible with water. Hence, does not require dehydration and clearing tissue
Carbowax
43
A polyethylene glycol containing 18 or more carbon atoms, which appears solid at room temperature, the ***best*** wax but very expensive
Carbowax
44
An example of Polymer waxes (Water-Soluble Waxes)
Carbowax
45
Substitutes for Paraffin wax
- Paraplast - Embeddol - Bioloid - Tissue mat - Ester wax - Water-soluble waxes - Carbowax

Histopath & MTLE (13 decks)

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