Multi-system Flashcards
What spinal issue can be see in duchenne
Scoliosis
Dx and Tx for Duchenne
Dx with either biopsy of muscle or genetic test. Tx with steroids
What can eventually occur in the joints of a DMD patient
Joint contractures
Why does CK drop in the progression of duchenne
As the muscle is replaced by fibrofatty infiltration… the CK will drop a bit
List so,e complications of Prada Willi syndrome
All relates to obesity. Sleep apnoea, DM, choking, gastric rupture. So make sure to limit food for these little chubby kids. Also can give GH, to increase vertical growth
Protruding Metopic suture, seen where
Seen in cris du chat
Name some of the less obvious edwards signs
Low set ears, small jaw, limited hip abduction
Screening recommendations for gon chlam infx
Annual NAAT test, for sexually active under 25 (or has RFs)
What is congenital contractural arachnodactylyl
A fibrilin II defect, causing Mariah features, except no CV or ocular signs
AL Amyloidosis main manifestations
Nephrotic syndrome, Hmeg, periorbital purpurin, waxy skin, restrictive cardiomyopathy
Why is lymphoedema not pitting
Because the protein concentration is high
Two reasons we need estrogen therapy in turners syndrome
For sexual development, but also to decrease risk of osteoporosis
The gene test we have to do for CHARGE syndrome
CHD7
Contrast manifestions of CREST and diffuse SS
CREST:
• Scleroderma on head & distal UE
Prominent vascular manifestations
• Raynaud phenomenon
• Cutaneous telangiectasia
• Pulmonary arterial hypertension
• CREST syndrome
Diffuse SS:
• Scleroderma on trunk & UE
• Prominent internal organ involvement
• Scleroderma renal crisis
• Myocardial ischemia & fibrosis
• Interstitial lung disease
Joint fluid:
> 10,000 wbc
> 75% PMN
culture it… likely septic
WBC numbers in joint fluid to remember for step
<2000 is normal
2,000-10,000 is inflam
> 10,000 is septic
Join fluid with blood and fat droplet
Maybe fracture
Foot puncture wound and osteoM… cover which bac
Pseudomonas
Adults vs kids. Osteomyelitis. Which is more from seeding and which from contiguous spread
Adults from spread, kids more seedinh
If patient had allergic rash on penicillin, can we give ceph? What about anaphylaxis or angioedema
Yes, and No
Are OA patients at higher risk of osteoporosis after Sx
Yes
Viscosity of joint fluid in inflam
Lower!
Retina bulls eyes appearance
Chloroquine tox
Don’t forget carpal tunnel from RA