Multiple endocrine neoplasia

Question 1

group of genetic conditions characterised by the formation of […]-producing tumours in multiple […] organs.

Answer 1

group of genetic conditions characterised by the formation of hormone-producing tumours in multiple endocrine organs.

Question 2

Multiple Endocrine Neoplasia-1 (MEN-1) features

Caused by mutation in the […] gene
3Ps
[…]: hyperplasia/adenomas
[…]: gastrinoma, insulinoma
[…]: prolactinoma

Answer 2

Multiple Endocrine Neoplasia-1 (MEN-1) features

Caused by mutation in the MEN 1 gene
Parathyroid: hyperplasia/adenomas
Pancreas: gastrinoma, insulinoma
Pituitary: prolactinoma

Question 3

Multiple Endocrine Neoplasia-2a (MEN-2a) features

Caused by mutation in the […] gene
TAP
[…]: medullary thyroid cancer
[…]: pheochromocytoma
[…]: hyperplasia/adenomas

Answer 3

Multiple Endocrine Neoplasia-2a (MEN-2a) features

Caused by mutation in the RET gene
Thyroid: medullary thyroid cancer
Adrenal: pheochromocytoma
Parathyroid: hyperplasia/adenomas

Question 4

Multiple Endocrine Neoplasia-2b (MEN-2b) features

Answer 4

Same as 2a + mucosal neuromas