Multiple Endocrine Neoplasia Flashcards Preview

Yr 2 Endocrine > Multiple Endocrine Neoplasia > Flashcards

Flashcards in Multiple Endocrine Neoplasia Deck (7):
1

What is MEN?

A group of inherited disorders
They present in the yuonger age group with multifocal hyperplasia/neoplasms of endocrine organs

2

How does MEN 1 occur?

Mutation in the Men 1 tumour suppressor gene
-> Defective menin protein production
-> Irregular cell growth

3

What are the features of MEN 1?

- Parathyroid Hyperplasia/Adenoma
- Pancreatic tumours (hypoglycaemia)
- Duodenal endocrine tumours (hypoglycaemia & ulcers)
- Pituitary adenomas (mainly prolactinoma)

4

What cause MEN 2?

Mutations in RET proto-oncogenes

5

What are the features of basic MEN 2?

Medullary Carcinoma of thyroid and pheochromocytoma

6

What are the features of the MEN 2A variant?

MEN 2 (medullary carcinoma & pheochromocytoma)

+ Parathyroid hyperplasia

7

What are the features of the MEN 2B variant?

MEN 2 (medullary carcinoma and pheochromocytoma)

+ Neuromas of skin, mucous membrane and skeletal abnormalities.