Flashcards in Multiple Endocrine Neoplasia Deck (7):
What is MEN?
A group of inherited disorders
They present in the yuonger age group with multifocal hyperplasia/neoplasms of endocrine organs
How does MEN 1 occur?
Mutation in the Men 1 tumour suppressor gene
-> Defective menin protein production
-> Irregular cell growth
What are the features of MEN 1?
- Parathyroid Hyperplasia/Adenoma
- Pancreatic tumours (hypoglycaemia)
- Duodenal endocrine tumours (hypoglycaemia & ulcers)
- Pituitary adenomas (mainly prolactinoma)
What cause MEN 2?
Mutations in RET proto-oncogenes
What are the features of basic MEN 2?
Medullary Carcinoma of thyroid and pheochromocytoma
What are the features of the MEN 2A variant?
MEN 2 (medullary carcinoma & pheochromocytoma)
+ Parathyroid hyperplasia