Multisystem V

Question 1

____ does NOT form pseudohyphae

Answer 1

Candida auris does NOT form pseudohyphae

Question 2

the pathogenicity of Candida is facilitated by _____

Answer 2

the pathogenicity of Candida is facilitated by adherence to tissues

Question 3

list 4 pathogenetic mechanisms of Candida spp.

Answer 3

• ability to exhibit yeast-hyphal dimorphism
• cell-surface hydrophobicity
• proteinase secretion
• phenotypic switching

Question 4

___ is a key feature of C. auris that contributes to its antibiotic resistance

Answer 4

phenotypic switching is a key feature of C. auris that contributes to its antibiotic resistance

Question 5

____ can cause serious bloodstream infections and is characterized by ____ and ___ that don’t improve after ____

Answer 5

Candida spp. can cause serious bloodstream infections and is characterized by fever and chills that don’t improve after antibiotic treatment

Question 6

____ is used to diagnose Candida spp.

Answer 6

MALDI-TOF is used to diagnose Candida spp.

Question 7

Candida spp. can be grown on ___ medium supplemented with ____

Answer 7

Candida spp. can be grown on CHROMagar medium supplemented with Pal’s medium

Question 8

Coxsackiviruses are part of the ____ family of viruses

Answer 8

Coxsackieviruses are part of the Picornaviridae family of viruses

Question 9

Coxsackieviruses are spread via ____ route of transmission

Answer 9

Coxsackieviruses are spread via fecal-oral route of transmission

Question 10

Coxsackieviruses infect ___ in Peyer patches as well as ____ in the intestinal mucosa

Answer 10

Coxsackieviruses infect M cells & lymphocytes in Peyer patches as well as enterocytes in the intestinal mucosa

Question 11

from the intestine, Coxsackieviruses can infect ____ cells

Answer 11

from the intestine, Coxsackieviruses can infect reticuloendothelial cells (LNs, spleen, liver)

Question 12

the binding receptors for Coxsackieviruses are ___ and ____

Answer 12

the binding receptors for Coxsackieviruses are ICAM-1 and CD55

Question 13

Coxsackievirus replicates in the ____ and produces a ____ that contains ____

Answer 13

Coxsackievirus replicates in the cytosol and produces a polyprotein that contains all the protein sequences

Question 14

____ antibody can prevent initial infection of oropharynx and GI tract with Coxsackievirus

____ antibody prevents viremic spread of Coxsackievirus to target tissues and thus disease

Answer 14

secretory antibody can prevent initial infection of oropharynx and GI tract with Coxsackievirus

serum antibody prevents viremic spread of Coxsackievirus to target tissues and thus disease

Question 15

describe the 2 diseases that Coxsackievirus A can cause

Answer 15

Question 16

describe the 2 conditions caused by Coxsackie B virus

Answer 16

Question 17

Answer 17

Question 18

HHV4 is also known as ____

Answer 18

HHV4 is also known as EBV

Question 19

list the 2 characteristic features of EBV infection

Answer 19

swollen lymph nodes in the neck

enlarged spleen

Question 20

the replication of EBV occurs in epithelial cells of the ___ & ___ and establishes latent infections in ____

Answer 20

the replication of EBV occurs in epithelial cells of the oropharynx & parotid gland and establishes latent infections in lymphocytes

Question 21

EBV in saliva initiates infection in ___ and ___ by binding ____

Answer 21

EBV in saliva initiates infection in oral epithelia and tonsillar B cells by binding CD21

Question 22

EBV promotes growth of ____ and therefore ___ act to control the overgrowth of the ____

Answer 22

EBV promotes growth of B-cells and therefore CD8 T cells act to control the overgrowth of the B cells

Question 23

summarize the pathogenesis of EBV

Answer 23

Question 24

the triad of classical symptoms in EBV are:

Answer 24

lymphadenopathy

splenomegaly

exudative pharyngitis

Question 25

HHV5 is also known as \_\_\_\_

Answer 25

HHV5 is also known as **CMV**

Question 26

CMV is linked to ____ transplant failures

Answer 26

CMV is linked to **kidney** transplant failures

Question 27

in severely immunocompromised patients, CMV can cause \_\_\_, ___ and \_\_\_\_

Answer 27

in severely immunocompromised patients, CMV can cause **retinitis**, **colitis** and **esophagitis**

Question 28

\_\_\_\_ is the most prevalent viral cause of congenital disease

Answer 28

**CMV** is the most prevalent viral cause of congenital disease

Question 29

list clinical features of CMV in neonates

Answer 29

Question 30

\_\_\_\_ is the standard for diagnosing CMV

Answer 30

**ELISA** is the standard for diagnosing CMV

Question 31

describe diagnosis of CMV

Answer 31

Question 32

summarize the congenital infections

Answer 32

Question 33

sensorineural hearing loss & chorioretinitis are seen in which congenital infection?

Answer 33

**Rubella**

Question 34

microcephalus and chorioretinitis are seen in which congenital infection?

Answer 34

**CMV**

Question 35

keratoconjunctivitis is seen in which congenital infection?

Answer 35

**HSV**

Question 36

failure to thrive, severe thrush and calcification of basal ganglia are seen in which congenital infection?

Answer 36

**HIV**

Question 37

skin lesions involving palms and soles, rhinorrhea, signs of osteochondritis and periostitis are seen in which congenital infection?

Answer 37

**syphilis**