Muscels Flashcards
(32 cards)
Somatic motor neurons consist of cell bodies located in :
their axons are :
CNS
Large myelinated
Synapse between axon terminal of somatic neuron & muscle fiber is
Neuromuscular junction
Action potential reaching axon terminal of motor neuron leads to opening of
Voltage-gated Ca++ channels
Voltage-gated Ca++ channels causing exocytosis of which neurotransmitter : binds to :
acetylcholine
cholinergic nicotinic receptors
Binding of acetylcholine to its receptors leads to
Na+ entry
After receptors stimulation, acetylcholine is hydrolyzed by
acetylcholinesterase enzyme
Skeletal muscle is made up of a group of
Muscle cells (muscle fibers)
Muscle fiber is covered by a membrane called :
Sarcolemma
Thick filaments :
Myosin
Thin filaments made up of :
Actin, Tropomyosin, Troponin.
Myosin consists of :
Two heads
Two heads of myosin attached to :
Double helix tail
Actin is arranged in the form of :
they have :
Double helix
Active sites
Tropomyosin arranged in form of strands that :
Cover active sites
Troponin is globular protein bound to
Tropomyosin
Sarcomere is the area that extend between :
Two adjacent Z discs
T tubules are invaginations in the sarcolemma that provide :
Path for rapid transmission of the action potential.
Sarcoplasmic reticulum are the site of
Ca++ storage
Excitation contraction coupling
Generation of :
Action potential
Excitation contraction coupling
Inward spread of depolarization along the :
T tubules
Excitation contraction coupling
Release of Ca++ from :
Sarcoplasmic reticulum
Excitation contraction coupling
Binding of Ca++ to :
causes tropomysin to :
allowing binding of :
Troponin ,
Move away from active site ,
Myosin head to actin active sites forming Cross bridges.
Excitation contraction coupling
Bending of myosin head causes sliding of actin over myosin, leading to :
Muscle shortening
Excitation contraction coupling
Energy generated from :
ATP