Musculoskeletal disorders? Flashcards
(28 cards)
What is antalgic gait?
a limp with weight bearing on the unaffected side, decreased swing phase of unaffected limb
Radiographic features of arthritis?
Joint space narrowing
Subchondral cysts
Osteophytes
Sclerosis
Clinical features of osteoarthritis?
Morning stiffness
Who does OA affect commonly?
Women
Management of OA?
Line 1: Education advice, weight loss support, strengthening exercises
Line 2: Paracetamol, topical NSAIDS
Line 3: Oral NSAIDs, opioids, capsaicin, injections, arthroplasty, supports/assisting devices
What is a T score?
Measurement of bone mineral density
T score in osteoporosis and osteopaenia?
T score of -1.0 to -2.5 - osteopaenia
T score of less than -2.5 - osteoporosis
What is osteopenia?
Slightly reduced bone mineral density
In what situations should you give a DEXA scan?
- Low trauma (osteoporotic) #
- Height loss/kyphotic
- Vertebral deformity on X ray
- FHx of #
- Steroid use
- Early menopause
- Low BMI
- Heavy smoker/excess alcohol/ malabsorption
Treatment choices for osteoporosis? Examples?
SERMs (Selective Estrogen Receptor Modulator) e.g. raloxifene
Bisphosphonates e.g. alendronate
Teriparatide is a synthetic parathyroid hormone
Denosumab
HRT
Exercise
Calcitonin
Mode of action of SERMs and Bisphosphonates?
SERMs - inhibit bone resorption by stimulating oestrogen receptor in bone
Bisphosphonates - bind to hydroxyapetite and inhibit osteoclast bone resorption
Risks associated with bisphosphonates?
Oesophageal ulcers
Risks associated with SERMs?
Risk of VTE
Worsen peri-menopausal vasomotor symptoms
When would you use a SERM?
Healthy post menopausal women worried about breast cancer, with vertebral osteoporosis (not effective in hip)
Teriparatide mode of action?
synthetic parathyroid hormone - increases formation more than it increases bone resorption.
Denosumab mode of action?
Inhibits formation of osteoclasts.
When would you use Teriparatide?
Steroid induced osteoporosis
Basic process of bone formation?
Bones initially appear as flat layers of CT
Mesenchymal stem cells in the CT differentiate to form osteoblasts
Bone matrix builds up to form trabeculae
Trapped osteoblasts become osteocytes
Basic process of cartilage formation?
Development of primary ossification centre at diaphysis
Marrow cavity formed by death of chondrocytes within bony collar
Longitudinal bone growth formed by chondrocyte hypertrophy at growth plate
Why does bone remodelling occur?
Adaptation to mechanical loading
Enabling fracture healing
Prevents “bone fatigue” by continually renewing matrix
Patho-physiology of arthritis?
Focal destruction of articular cartilage
Remodelling of adjacent bone = hypertrophic reaction at joint margins (osteophytes)
Remodelling and repair process (efficient but slow)
R/F for osteoarthritis?
Family history (genetics)
Obesity
Ligament rupture
Fracture through joint
Malalignment
Occupational factors
OA treatments?
Exercise
Capsaicin
NSAIDS
Opioids
Joint steroid injection
Replacement
TENS machine
What is an autologous bone graft, and a allogenic bone graft?
Specific bone graft with the patients human stem cells - autologous
Off the shelf made from an animals stem cells - allogenic
