Musculoskeletal system Flashcards Preview

Pharmacy Pre-Registration 20/21 > Musculoskeletal system > Flashcards

Flashcards in Musculoskeletal system Deck (14)
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1
Q
Azathrioprine
Ciclosporin
Cyclophosphamide
Leflunomide
Penicillamine
Methotrexate
Gold

Are all seen in which condition?

A

These are the DMARDs used in Rhumatoid arthritis

2
Q

Hydroxychloroquine is indicated for active rhumatoid arthritis. What is a big warning with this drug?

A

Screening for ocular toxicity is required- monitor visual symptoms during treatment

3
Q

What drugs are used in the treatment of Gout?

A

Colchicine
Allopurinol
sulfinpyrazone
febuxostat

4
Q

What severe hypersensitivity reaction has been associated with Febuxostat use?

A

Steven Johnsons syndrome

Stop immediately if steven johnsons ulcer like rash occurs

5
Q

Why must we avoid abrupt withdrawal with Baclofen?

A

Risk of hyperactive state- hyperthermia, psychiatric reactions, convulsion. Dose should be discontinued gradually over 1-2 weeks

6
Q

What should patients on Baclofen be advised with regards to driving?

A

Baclofen may cause drowsiness

7
Q

What is baclofen used for?

A

Pain of muscle spasms in palliative care
Hiccups in palliative care
Muscular sclerosis etc

8
Q
What are 
Aceclofenac, 
Acemetacin, 
Celecoxib, 
Etodolac,
Felbinac
Indometacin
Mefenamic acid 
All examples of?
A

NSAIDs

9
Q

Why have restrictions on the use of Piroxicam been put forward?

A

Increased risk of Gastro-intestinal side effects and of serious skin reactions.

Should not be used first line
Should be initiated by a specialist
Should only be used for rheumatoid arthritis not for pain anymore
(this guidance does not effect topical preps only oral)

10
Q

What is the big safety warning with TIAPROFENIC ACID (an NSAID)?

A

It can cause SEVERE CYSTITIS
DO NOT give to patients with UTI disorders!

Stop if symptoms develop- increased frequency, nocturia, urgency, pain on urination, blood in urine.

11
Q
Etanercept
adalimumab
Liximab
Certolizumab
Golimumab 
Infliximab

What are all these used in?

A

Rhumatoid arthritis

Chrons

Ulcerative colitis

‘Cytokine Modulators’

12
Q

What should patients taking Cytokine Modulators be advised to look out for?

Etanercept
adalimumab
Liximab
Certolizumab
Golimumab 
Infliximab
A

TUBERCULOSIS:
(they’re immunosuppressant so infection with TB more likely)
Signs: persistent cough, Hemoptysis (coughing blood), weight loss

BLOOD DISORDERS:
agranulocytosis: fever, sore throat, bruising, bleeding

13
Q

Which NSAID carries the lowest risk of CV effects?

A

Naproxen

14
Q

Which NSAID carries the lowest risk of Gastro-intestinal side effects?

A

Ibuprofen

Decks in Pharmacy Pre-Registration 20/21 Class (82):