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MICROBIOLOGY 2.0 > Mycobacterium > Flashcards

Mycobacterium Flashcards

0
Q

Enzyme characteristic of m leprae

A

O-diphenoloxidase

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1
Q

First pathogen demonstrated in human tissue

A

M leprae

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2
Q

M leprae grows on Nutrient agar. True or false

A

False. Doesnt grow on any artificial medium. Obligate intracellular

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3
Q

M leprae causes systemic disease

A

False

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4
Q

They grow well above 30 degrees. M leprae

A

False

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5
Q

M leprae can be associated as an immediate cod

A

False

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6
Q

M leprae prefers hot surfaces of the body like axilla and groin

A

False

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7
Q

Basis for diagnosis of leprosy

A

Clinical manifestations

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8
Q

Nasal secretions of m leprae can survive for how long?

A

36hours

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9
Q

M leprae is HIGHLY infectious

A

False. Takes 3-4 years to have disease

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10
Q

Incubation period can last up to several years

A

True. 30 years

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11
Q

Animal used for research in leprosy

A

Armadillo

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12
Q

Most infectious source of m leprae

A

Nasal discharges

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13
Q

Immediate forma of leprosy

A

Borderline

Intermediate

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14
Q

BI measures what

A

Bacterial load

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15
Q

MI measures what

A

Bacterial viability

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16
Q

Mainstay drug for leprosy

A

Dapsone. Clofazimin. Rifampin

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17
Q

Combination therapy

A

1-2 years

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18
Q

Sign of restoration of CMI after onset of treatment

A

Erythema nodosumleprosum ENL

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19
Q

Multiple nodular lesions in the face

A

Leonine facie

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20
Q

Deficient CMI

A

Lepromatous

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21
Q

High levels of IL 4 and 10

A

Lepromatous

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22
Q

Diagnosis requires AFB stain, foam cells and false positive syphilis

A

Lepromatous

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23
Q

A granuloma is sufficient for diagnosis

A

Tuberculoid

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24
Exam for sub clinical infxn of leprosy
Lepromin skin test
25
Lepromatous tests positive on lepromin st
False. Tuberculoid
26
Single lesion tx
ROM Rifampin Ofloxacin Minocycline
27
Scrapings must be stained with?
Ziehl Neelsen
28
Serologic tests are valuable
False. No effect
29
This causes Buruli cancer
M ulcerans
30
Classified as a scotochromogen
M scrofulaceum
31
MOTT grows at 41 degrees
MAC or MAI
32
Grows at 37 degrees MOTT
M kansaii
33
Photochromogen
Kansaii. Group I
34
Grows rapidly non pigmented
M fortuitum
35
Has niacin
TB COMPLEX
36
DOC for group 4
F-DA DOXY AZITHRO
37
Prophylaxis for MAI
Rifabutin
38
Initial tx for MAC
ACE Azithro Clarithro Etham
39
Maintenance for MAC
For life. RAF-C Rifabutin Azithro Fluoro Clarith
40
MOTT occuring to those with prosthetic hip joint and indqelling catheters
M fortuitum
41
Only tx is removal of lymph node
Scrofula
42
How to prevent leprosy spread
Isolate ALL
43
Sudden asymmetric nerve involvement
Tuberculoid
44
High CMI
Tuberculoid
45
What makes m tubercle acid fast
High lipid content of cell wall
46
They are obligate pathogen. M tubercle
True
47
They are non pathogen common in smegma
M smegmatis
48
This stain creates rods red in blue background
Ziejl neelsen
49
Culture of m tubercle
Small, scaly dry corrugated surfaces
50
Are m tubercle killed by heat
True
51
How long does m tubercle in putrefying sputum lives. In dried?
Weeks 6-8 mos
52
M tubercle are difficult to disinfect. Use what
5% phenol
53
M tuerculosis and bovis are equally pathogenic to man
True
54
More potent than PPD
Seibert proteins A an B
55
Virulence factor of TB
Serpentine cord
56
Avirulent culture
Random Brush heap patter
57
His causes serpentine cord formation
Trehalose dimycolate
58
Primary lesion of TB
Lower lobes
59
Secondary lesions
Apex
60
Define CATEGORIES OF TB
``` 0 no exposure 1 exposed 2 tb infxn 3 current tb dse 4 previous tb dse 5 tb suspect ```
61
What causes night sweats in tb
tnf release
62
Define reinfection from relapse
Diff strain. Same strain
63
Solid medium culture
Lowenstein-jensen
64
Liquid medium
Middlebroom
65
How many specimens must be collected?
2x consecutive days
66
Define ghon complex
Parenchymal exudative lesion plus draining lymph node
67
Define tb inactive
Dormant org persist but no longer actively multiplying
68
Doubling time o m tubercle
18h
69
Common age bracket affected with TB
2 years old above
70
Molecular dx for better indication o mycobacterial cell viability
Rna and Mrna
71
Stain used in ziehl neelsen
Carbolfuschin
72
Destroys other undesired organism in a culture of m tubercle
KOH
73
Reading of PPD
48-72h
74
This vaccine does not prevent having the dse but prevents the complications
BCG
75
Mutation on pyrazimindase
Pzh
76
Mut on katG
Inh
77
Mut on rpoB
Rifampicin
78
Beta subunit of the DNA dependent RNA polymerase mutation
Rifampicin

MICROBIOLOGY 2.0 (7 decks)

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