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MICROBIOLOGY 2.0 > Spore Forming > Flashcards

Spore Forming Flashcards

0
Q

Non motile, aerobic, spore forming

A

Bacillus

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1
Q

Rods in chains with square ends and spore at the center

A

Bacillus sp

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2
Q

Anaerobic, motile (f), toxin mediated

A

Clostridium

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3
Q

1st dse attributed to a bacterium

A

B anthracis

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4
Q

1st bacterial disease prevented by vaccination

A

B anthracis

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5
Q

This sp shows no hemolysis

A

B anthracis
C tetani
C botulinum

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6
Q

This sp shows hemolysis

A

B cereus

C perfringens

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7
Q

Liquifies gelatin

A

Bacillus

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8
Q

C tetani causes systemic invasion

A

False. Localized

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9
Q

C tetani causes the s/sx

A

No, toxin mediated

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10
Q

Mode of migration of tetanospasmin

A

Retrograde migration

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11
Q

What enzyme does tetanospamin degrades that prevents docking of vesicles

A

Synaptobrevin

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12
Q

What produces tetanospamin

A

Vegetative c tetani

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13
Q

What nts does tetanospamin block

A

Gaba and glycine

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14
Q

True or false. Small amount of tetanospasmin is not lethal. Requires large amount.

A

False

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15
Q

Target of tetanospasmin

A

Anterior horn cells

BS

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16
Q

What aids in spore germination and toxin prod

A

Low redox potential

Calcium salts
Necrotic tissue
Asso pyogenic infxns

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17
Q

Tetanus has CNS manifestations like altered LOC

A

None, fully conscious

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18
Q

Trismus

A

Contraction of jaw muscles

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19
Q

Risus sardonicus

A

Contraction of facial muscle

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20
Q

Test to check for trismus and risus

A

Spatula test

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21
Q

Cod in tetanus

A

Respi muscle arrest

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22
Q

IP for tetanus

A

4-5 days even weeks (jawetz)

average 14 (lecture)

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23
Q

Strychnine poisoning

A

Used for ddx in tetanus

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24
Antimicrobials for tetanus
Pen G | Metro
25
What organism has their spore centrally located
Bacillus
26
The're spores are usually larger than the rod itself. Located terminally
Clostridium
27
Most powerful neurotoxin
Botulinum toxin
28
Affects primarily the cranial nerves thus PNS
Botulinum toxin
29
Proteolysis of SNARE proteins
Synaptobrevin Syntaxin Snap 25 Botulinum toxin
30
Toxin A and B
Adult | Canned goods 1-2 days
31
Toxin E and F
Infant 3-30 days Honey
32
GI sx not prominent | NO FEVER
Botulism
33
What toxin causes floppy baby syndrome
Toxin e and F
34
Do patients who recovered from botulism will develop antitoxin thereafter?
NO. Susceptible ulit
35
Diagnosis of botulism
Passive hemaglutination | Radioimmunoassay
36
To what age group is stool exam useful for dx of botulism
Infants only and not in serum
37
Do antimicrobials have effect on botulism
None
38
This org has virulence factor of theta toxin alpha and DNAse and hyaluronidase
C perfringes
39
Characterized with hemolysis thus causing anemia
C perfringes
40
Presents with fever
Perfringes | Difficile
41
How can lecithinase activity be seen
Precipitate formation around egg yolk media
42
What do u call the rxn in lecithinase activity
Nagler rxn
43
What sp is associated with antibiotic induced proliferation
C difficile
44
Difficile produces fever?
True
45
What abx usually cause c difficle
FAC u difficle FLUORO AMPI CLINDA
46
Tx for difficle
Dc of offending abx | Give metro or vanco
47
Which clostridium sp has a double zone of hemolysis
C perfringess
48
Has large raised colonies
Perfringens
49
Presence of intestinal pseudomembranes
C difficle
50
Has large rectangular spores
Perf
51
Has squash racket spore
Tetani
52
Has oval subterminal spore one is bigger
``` C botulinum C difficile (larger) ```
53
Botulinum is heat labile
True
54
What bacillus produces enteroroxin
Cereus
55
Which bacillus has vaccine
Anthracis
56
Which bacillus is capsulated
Anthracis
57
Which bacillus is motile
Cereus
58
Which bacillua is hemolytic
Cereus
59
Which bacilli has medusa head
Anthracis
60
Which is bamboo cane like
Anthracis
61
Which bacillus has whipped egg white
Anthracis
62
Which bacillus has lecithinase
Cereus
63
What causes virulence in anthracis
Poly d glutamic acid capsule | Anthrax toxin
64
Which comes from Pxo2
Capsule
65
From pxo1
Toxin
66
Abx are effective in vegetative forms and even spores
False. Not in spores
67
Only respi anthrax has delayed onset
True
68
Time when eschar is fully developed
After 7-10 days
69
This type of anthrax leads to meningitis
Cutaneous and inhalataion
70
Ciprofloxacin
Doc for cutaneous anthrax
71
Doc for endemi anthrax
Pen G
72
Doc for cereus
Vancomycin
73
Doc for cereus immunocom
Penicillin
74
Are bacillus aerobe?
Yes
75
Are clostridium anaerobe
Yes

MICROBIOLOGY 2.0 (7 decks)

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