Myositis Flashcards
(26 cards)
What is Myositis?
Inflammation of the body’s CT and Muscles
What is Polymyositis?
Inflammatory myopathies with proximal muscle weakness
What is a classic presentation of Polymyositis?
difficulty getting up from a seated position or walking up stairs
Dysphagia from involvement of striated muscles of the pharynx making it difficult to initiate swallowing
What antibodies are associated with Polymyositis?
Anti-Mi-2 Antibodies
What is Dermatomyositis?
Inflammatory and degenerative changes of the muscles and skin
What are classic presentations of Dermatomyositis?
Malar involvment
Shawl sign
Heliotrope rash
Gottron papules
What is the Shawl sign in Dematomyositis?
Erythema of the face, neck, shoulders, upper chest and back
What is the Heliotrope rash in Dermatomyositis?
Edema and purplish discoloration of the eyelids
What are Gottron Papules?
Scaly patches over the back of hands: particularly PIP and MCP joints
What is the best initial test for Myositis?
Elevated CPK and Aldolase
What is the most accurate test for Myositis?
Muscle Biopsy
What antibodies are associated with lung fibrosis in Myositis?
Anti-Jo-1
What does MRI detect in Myositis?
Patchy Muscle Involvement
How is Myositis treated?
Steroids
How do you treat Myositis if steroids are not effective?
Methotrexate
Azathioprine
IVIG
Mycophenolate
What drug helps with skin lesions in Myositis?
Hyroxychloroquine
What is inclusion body myositis?
slowly progressive weakness of both distal and proximal muscles particularly affecting the distal upper extremity flexors
What is seen on examination in inclusion body myositis?
Weakness of the quadriceps and a weakened ability to make a fist at the same time
What is the most accurate test for Inclusion Body Myositis?
Muscle Biopsy
What lab value is elevated in inclusion body myositis?
Creatine Kinase
How is inclusion body myositis treated?
There is no treatment
What is Mixed Connective Tissue Disease (MCTD)?
overlap between SLE, Scleroderma, and Polymyositis
Hoes does Mixed Connective Tissue Disease (MCTD) present?
Joint pain with
-hand edema and synovitis
-myositis and pulmonary hypertension
-sclerodactyly, calcinosis, malar rash
-gottron rash
-kidney involvment
-serositis and sicca symptoms
What is the most specific test for Mixed Connective Tissue Disease (MCTD)?
anti-U1-Ribonuclear Protein (anti-RNP)
