N18 - Analgesics (Breivogel) Flashcards Preview

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Flashcards in N18 - Analgesics (Breivogel) Deck (33):
1

paracrines

early immune response

2

TNF, ILs

Chronic inflammation

3

precursor for all eichosanoids

arachidonic acid

4

precursor to all prostaglandins and thromboxanes

PGH2

5

Inhibits aggregation

OAH

6

+ platelett aggregation

TXA2

7

Inhibits secretino of NSAIDs in to renal tubule

Probenecid

8

Contraindications to NSAIDs

Hypersensitivity

Renal impairment

Pregnancy, acetaminophen

9

aspirin

irreversibly inhibits COX-I

Reversibily inhibits COX-II

10

Chemoprevention when used alone or with dipyridamole

Aspirin

11

CNS effectiveness

acetaminophen

12

Increases platelet aggregation

COX-I

13

Involved in contractions

COX-II

14

Inhibition of induced/CNS COX I & II

decreased pain, inflammation, fever

15

Inhibition of COX II in uterus

decreased menstrual cramps

delayed labor

16

Inhibition of COX I in platelets

chemoprevention

blood thinning/bleeding

17

Inhibition of COX I in GI tract

 

ulcers

18

Inhibition of COX II in vascular endothelium

heart attack

stroke

19

Inhibition of COX I or II in fetus

closure of ductus arteriosus

20

Inhibition of COX I & II in kidney

decreased RBF & GFR

other drug intoxication

21

pt on meds for depression

methotrexate and Lithium elimination slowed

both have narrow therapeutic index

22

Tx for NSAID overdose

gastric lavage

23

Reye's Syndrome

Due to virus in children <12 taking aspirin

24

Suppository or enema alicylates for IBD

Sulfasalazine

Olsalazine

Mesalamine

25

special use to close ductus arteriosus after birth

stopping or slowing pre-term labor

Indomethacin

26

Propionic acids

Ibuprofen + hydrocodone

Naproxen

Fluribiprofen

Ketoprofen

Fenoprofen

Oxaprozin

27

CNS side effects less common than with aspirin

Tolmetin

Ketorolac

Diclofenac

28

Oral admin; SE - hemolytic anemia, visual distrubance

Mefenamic acid

Meclofenamate

 

29

Meloxicam

Piroxicam

Etodolac

 

- somewhat COX II selective

30

31

Increased risk of cardiovascular events

Acetaminophen

32

Decreased risk for gastric ulcer

acetaminophen

33