N5 - CNS Inf. III (Kuo) Flashcards Preview

4.1 > N5 - CNS Inf. III (Kuo) > Flashcards

Flashcards in N5 - CNS Inf. III (Kuo) Deck (50):
1

Early delay

- Viral DNA polymerase

- Thymidine kinase

 

Herpesvirus

2

Cell-cell bridges

Herpesvirus

3

Latent infection

Herpesvirus

4

Tzanck Smear

Multinucleated giant cells - Herpesvirus

5

Diagnosis for HSV encephalitis

PCR of CSF

6

HSV-1

 

Encephalitis (temporal lobe)

7

HSV-2

Meningitis

8

Stomatitis

HSV

9

Gingivostomatitis

Primary herpes

10

Site of viral latency

Trigeminal ganglia

11

Cold sore

Genitals

Recurrent herpes labialis

12

Trigeminal ganglia

HSV-1 latency

13

Lumbar & sacral ganglia

HSV-2 latency

14

HSV encephalitis severely affects

Temporal and inferior frontal lobes

15

reactivation from latency in the geniculate ganglioin

Bell's Palsy

16

17

treatment of choice for HSV encephalitis, systemic disease, recurrent genital herpes

Acyclovir

18

used for treating HSV-1 resistant to acyclovir

Foscarnet

19

First step of Acyclovir MOA

herpesvirus-encoded thymidine kinase phosphorylates it

20

Respiratory spread

Varicella zoster virus

21

chickenpox

VZV

22

Dewdrop on a rose petal

Varicella

23

Interstitial pneumonia

Varicella - adults

24

dorsal root or cranial nerve ganglia

thoracic dermatome

herpes zoster/shingles

25

supporting cells of the CNS i.e. astrocytes

CMV

26

oropharynx

CMV initiated infection

27

Infant congenital infections

CMV

28

Immunocompetent adults with CMV

Guillain-Barre

Acute brachial plexopathy

29

Organ transplant recipients and AIDS patients with CMV

encephalitis

myelitis

retinits

polyradiculitis

30

Neonate CMV transmission

Transplacental

Intrauterine

Cervical secretions

31

Adult CMV transmission

Sexual - semen

Organ graft

Blood transfusion

32

considered sexually transmitted disease

CMV

33

heterophile-negative mononucleosis syndrome

CMV

34

Tx of CMV

Ganciclovir

35

Owl's eye

basophilic intranuclear inclusion body

In uruine

CMV

36

Arthropod-Borne Viruses (Arboviruses) familes

Flaviviridae (alphavirus)

Togaviridae (alphavirus)

Bunyaviridae

37

yellow fever virus

Flaviviridae

38

dengue virus

Flaviviridae

39

Colorado tick fever virus

Reoviridae

40

St. louis encephalitis

West nile

 

Flaviviridae

41

North-central states

California virus - Bunyaviridae

42

High mortality

Eastern equine encephalitis virus - Togaviridae

43

Most common arbovirus

West nile

44

Dead end host of arbovirus

Humans

Horses

45

Reservoir of arboviruses

Marsh bird

46

Vector of arbovirus

mosquito

47

Arboviruses replicate within its

vector - insect

48

diseases caused by alphaviruses & flaviviruses

Mild systemic disease

encephalitis

arthrogenic disease

hemorrhagic disease

49

Arbovirus - systemic symptoms

Initial viremia

50

Arbovirus- virus reproduction

secondary viremia