N45-46 Flashcards Preview

Neuro > N45-46 > Flashcards

Flashcards in N45-46 Deck (33)
1

Acetylcholine at motor end plate

Nicotinic coupled to Na channels for depolarization of the muscle cell and contraction

2

Acetylcholinesterase

hydrolyzes the ACh

3

GABA

inhibitory effects in CNS

4

Valium

enhances GABA effects for muscle relaxation

5

Dopamine

activation of DIRECT pathway, death of nigrostriatal neurons causes parkinsonism

6

Glycine

inhibitory (spinal reflexes)

7

Strychince and tetanus toxin

block glycine receptors and cause tetanic contractions

8

Aspartate and glutamate

excitatory

9

Antiepileptic drug (felbamate)

blcks NMDA (glutamate) receptors

10

Tubocurarine/Pavulon

competitive non-depolarizing nicotinic blockade

11

Succinylcholine

depolarizing blockade (initial depolarization followed by a blockade)

12

Neuromuscular blockades

cause paralysis by blocking neuromuscular junctions but still conscious

13

Acetylcholinesterase inhibitor

prevents hydrolysis of acetylcholine

14

Myasthenia Gravis

decreased number of cholinergic receptors, ACH inhibitors raise ACh in synaptic clefts

15

Insecticides

ACh inhibitors, ACh cannot unbind nicotinic receptor

16

Valium and benzo

enhances GABA in CNS for relaxation, does this by enhancing GABAs ability to open associated Cl channel for relaxation effect

17

Benzo treats

acute muscle spasms

18

Baclofen

GABA agonists that inhibits excitatory neurons

19

Valium

treats spastic muscles, enhances GABA

20

Baclofen

muscles spasms from UMN lesion, ALS, spinal cord injury (GABA agonist)

21

Baclofen side effects

CNS depression

22

Dantrolene

direct acting muscle relaxant, inhibits Ca release in SR (malignant hyperthermia, neuroleptic malignant syndrome)

23

Convulsive stimulants

strychnine, tetanus toxin

24

Strychnine

recurrent inhibition by renshaw cells via glycine inhibition, strychnine is a glycine antagonist -->tetanic seizures

25

Tetanus toxin

inhibits release of glycine from renshaw cells

26

Treatment for Parkinsons

death of dopaminergic neurons, resulting in increased ACh, treatment involves increased dopamine or reducing ACh

27

Causes for Parkinsons

MPTP compound --> MPP+ toxin accumulates in substantia nigra

28

I-DOPA

Dopamine precursor to raise dopamine levels

29

Eldepryl

inhibits metabolism of dopamine by MAO-B

30

Entacapone (Comtan)

inhibits COMTand slows metabolism of dopamine in cleft

31

Bromocryptine (Parlodel)

stimulates dopamine receptors

32

Amantadine (Symmetrel)

stimulates release of dopamine

33

Benztropine (cogentin)

muscarinic antagonist