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Flashcards in Development N17 Deck (39)
1

NS deals with a ________ environment

predictable

2

Genetic determinants

most of the NS circuitry is established prenatally

3

To deal with variations in habits, social environment, and physical attributes

the CNS maintains the ability to modify its connections, called adaptive adjustments

4

Sensitive (critical) period

a period during which the capacity to adjust the NS circuitry in response to environment becomes limited

5

A range of functional properties exist that a circuit could adopt, but if the appropriate experiences are not gained

circuits never attain the ability to process information in a typical fashion (impaired perception and behavior my be permanent)

6

Experience shapes the visual cortex

depriving visual stimuli, results in cortical blindness, meaning the visual cortex no longer responds to visual input

7

Hubel and Wiesel experiment proves the sensitive period

sutured monkey's eye closed from 0-6 mo, animal was blind in that eye (cortical blindness)

8

Congenital cataracts prove the sensitive period

Congenital cataracts removed during infancy results in full vision
Cataracts removed between 10-20 resulted in the inability to perceive shape and form

9

Primary visual cortex

where information from two eyes first comes together; located in occipital lobe

10

Visual experience early in life determines

how much visual cortex is devoted to processing input (via neurons in the LGN) and degree to which inputs are combined

11

Layer 4 of the primary visual cortex

inputs from each eye cluster separately here, cells activated by each eye send input to common target cells above and below layer 4

12

target cells above and below layer 4 of the primary visual cortex receive input from

BOTH the right and left eye (SMALL proportion respond exclusively to 1 eye)

13

Binocular interaction

represented by the anatomical convergence on the same target

14

Visual experience during the sensitive period

results in competition among afferents from the LGN to layer 4; normally the eyes are used equally resulting in equal ocular dominance columns

15

Unequal balance between LGN afferents, due to vision impairments (monocular lid closure or cataracts) causes

impaired eye to lose the ability to drive layer 4 neurons in a large region of the cortex, LGN afferents from the normal eye GAIN ability to drive layer 4 neurons in a larger portion on the cortex

16

Result from impaired eye on functional properties

activity in the visual cortex becomes driven largely by LGN afferents from the normal eye

17

Axonal Architecture also changes if visual experience is withdrawn

axonal arbors of the LGN to layer 4 shrink in the impaired eye and expand in the normal eye

18

In cats, 1 week deprivation of visual stimuli before 6 mo of age results in

complete loss of vision; whereas deprivation in an adult has no effect

19

Critical period

period of maturation of cortical connections that is reliant on experience and stimuli

20

Closure of sensitive periods

once adequate experience is perceived, the circuit IRREVERSIBLY commits to a pattern of connectivity

21

Experience-driven sharpening of functional tuning

Major factor that decreases the plasticity of circuits; experience selects for anatomical connections and synaptic efficacy that refine excitatory and inhibitory connections, once this refining takes place it is difficult to alter via different experiences

22

Deprivation of appropriate experiences causes the sensitive period to be ________

prolonged

23

Raising cats in complete darkness would

prolong the critical period for ocular representation in the visual cortex

24

What event triggers sensitive period adjustments?

powerful and repeated activation of neurons at the site where change takes place

25

WIthout powerful and repeated stimuli

the pathway remains in an uncommitted state and capable of adjusting to experience

26

Therapeutic aspect of the critical period

Someone with abnormal sensory input, can be deprived of all relevant sensory input until the abnormality is corrected, resulting in a prolonged sensitive period rather than a commitment to an abnormal pattern of connectivity

27

Principles of developmental learning

Mainly regulated by genetic predisposition, limited range of stimuli can influence the circuit

28

Filial imprinting

a rapid discrete time segment in which animals display imprinting on the first stimuli they see

29

Babies in the process of imprinting

preferentially like images that resemble member of their own species

30

Sensitive periods exist for:

fundamental capacities (stereoscopic vision, visual acuity, binocular coordination) and high-level capacities (social behavior, language, perception of shapes and faces)

31

Language sensitive period

before 7 y/o a 1st or 2nd language results in thorough command of language; after 7 y/o the degree of proficiency decreases progressively (does not affect the ability to learn new words)

32

Language is processed in the ____ hemisphere

left "dominant"

33

If a 2nd language is learned before 7y/o the areas of the brain _________ with that of the 1st language. If a 2nd language is learned after 7 y/o the areas of the brain _________ with that of the 1st language

Overlap before 7y/o; do not overlap after 7y/o

34

Social behavior depends on social experiences at specific periods of neuronal development

Social deprivation in the early months of life result in developmental delays and hospitalism syndrome, by age 2-3 the development was still delayed suggesting structural deficits in brain development

35

Hospitalism syndrome

Rene Spitz's term for infants that were raised in a hospital and lacked the appropriate social stimuli which went on to have retarded physical development, and disruption of perceptual-motor skills and language

36

Theory of Mirror Neurons Circuitry

Specific type of neuronal population in the frontal and parietal lobes (also in areas related to visions and memory) necessary for imitation learning, understanding of others' mood and actions, identity and imitation of adults

37

Dysfunction of mirror neurons may lead to _____

autism and the inability to empathize

38

Mirror neurons are subject to critical periods

plasticity is minimal following critical period

39

Mirror neurons fire when

either the individual acts or when the same action done by another individual is perceived