Neglected tropical diseases 4 Flashcards
(32 cards)
What causes chagas disease?
parasitic protozoan–> Trypanosoma cruzi
Which organism spreads T. Cruzi?
Kissing bugs, triatomine bug
Where is chagas disease mainly seen?
Continental latin american countries
Non insect methods of chagas disease transmission?
Blood transfusion, oral, congenital
Two phases og chagas disease?
Acute and chronic
How is chagas disease prevented?
Insectisides and bed nets
How is chagas disease treated?
anti-parasitic medication, benznidazole and nifurtimox
Effectivity of chagas treatment over time?
Decreases over time
Three forms of T.Cruzi?
Trypomastigotes, amastigotes, epimastigotes
Replicative forms of T. Cruzi?
Epimastigotes and amastigotes
Where are epimastigotes found?
Insect midgur
Where are amastigotes found?
Mammalian cells
Where are trypomastigotes found?
Insect vector and bloodstream of human host
Features of trypomastigotes?
Non-proliferative but can infect new cells
Where do triatomine bugs usually bite?
Face/mouth
What happens after the triatomine bug bites on the face/mouth?
T.cruzi enters the human bloodstream via the wound site
Where in the triatomine bug is T.Cruzi found?
The faeces
What happens to trypomastigotes after they have infected a cell near the bite wound?
They transform into an amastigote
What happens once amastigotes are formed?
They multiply by binary fission in the cells of the infected tissue
What causes localised swelling at the wound site of the T.cruzi infection?
Binary fission of amastigotes in the cells of the infected tissue
What happens to amastigotes once they have replicated via binary fission?
They transform into trypomastigotes, and burst into the bloodstream
What can trypomastigotes do once in the bloodstream?
Travel to new infection sites, where they transform into amastigotes b4 replicating again
What occurs in the new infection sites?
Massive swelling
What happens if another triatomine bugs bites someone infected with T.Cruzi?
It ingests t.cruzi
