Neoplasia Flashcards
(174 cards)
0
Q
Drug which acts on S phase
A
Mtx
1
Q
Exceptions to -oma rule
A
Glioma Mesothelioma Lymphoma Seminoma Neuroblastome
2
Q
Drug which acts on M phase
A
Vincristine
3
Q
Biochem changes in malignant cells
A
Shift to anaer glycolysis
Incr uptake of glu
Inc storage of glucose as glycogen
4
Q
Benign tumor which invades tissue
A
Dermatofibroma
5
Q
Benign tissue nt enclosed by fibrous capsule
A
Uterine Leiomyoma
6
Q
Axn of bevacizumab
A
Inhib binding of vegf to endoth cells
7
Q
Most imp criteria for malign
A
Metastatize
8
Q
Tumor which invades tissue but does nt met
A
Basal cc
9
Q
Mc met site in bone
A
Vert column
10
Q
Mc ca spreding to bone
A
Breast ca
11
Q
Mc ca to activ OB
A
Prostate ca
12
Q
Ca which activ OC
A
Lung ca
Rcc
Breast ca
13
Q
Mc ca to met to lungs
A
Brst
14
Q
Mc ca to met to liver
A
Lung
15
Q
Mc ca to met to brain
A
Lung
16
Q
Mc site of mets
A
Ln
17
Q
Mcc of ca
A
Tobacco
18
Q
Mcc of disease rel deaths b/w 1-14 y/o
A
Malignant neoplasm
19
Q
Mc ca in children
A
ALL leukemia
20
Q
2nd mc ca in children
A
Cns - cerebellar
21
Q
3rd mc ca in children
A
Neuroblastoma
22
Q
Common ca in children which r not common in adults
A
Retinoblastoma Wilms Osteogenic sarcoma Ewing sarcoma Embryonal rhabdomyosarcoma
23
Q
Common ca in adults which r nt common in children
A
Carcinomas
24
Mc gyn ca
Endom>ovary>cervic
25
RB1 gene located on chr
13
26
Mc secondary malign of RB
Osteogenic Sa
27
Cause of lynch syndr
Hnpcc- msi (microsatellite instability) due to inactivation of mmr (mismatch repair) genes
28
Ataxia telangiectasia
Inc risk for malign lymphoma
29
Bloom syndr
Inc risk for malign lymphoma, gi tumors
30
Fanconi syndr
Inc risk for malign lymphoma, scc, hcc
31
Most rqpidl inc ca in the world
Mm
32
Mc ca in china
Np ca
| Scc of esoph
33
Mc ca in japan
Stomach adenoca
34
Mc ca in SE asia
Hcc
35
Mc ca in africa
Burkitt lymphoma
| Kaposi sa
36
Mc mutn in ca
Point mutn
37
Mc gene prod ca
P53
38
Mutn in ABL gene causes
Cml
39
Mutn in c-myc causes
Burkitt lymphoma
40
Mutn in n-myc causes
Nb
| Small cc of lung
41
Mutn in ret causes
Multi endocr neoplasia
| Leukemia
42
NF1
AD-Pheocheomocytoma
Wilms
Neurofibrosarcoma
Somatic - nb
43
NF2
Bilat acoustic neuroma
| Meningioma
44
Mutn in RB1 gene causes
RB
| Osteog Sa
45
Mutn in tgf-b causes
Familial stom ca
| Somatic pancr/colorectal ca
46
Vhl syndr
Cerebellar hemangioblastoma
Retinal angioma
BiL rcc
BiL pheochrom
47
Antiapoptotic genes
Bcl2
48
Bcl2 genes loc on chr
18
49
Mutn of anti apoptotic genes causes
B cell follicular lymphoma
50
Mc carcinogens in us
Polycyclic hydrocarbons in tobacco smoke
51
Aflatoxins cause
Hcc - hep b
52
Alkyl agents cause
Malignant lymphoma
53
As causes
Scc of skin
Lung ca
Liver angiosa
54
Azo dyes cause
Hcc
55
Common source of as
Herbicides
| Cig smoke
56
Common source of asbestos
Roofing material
| Insulatiob
57
Asbestos causes
Bronchogenic ca
| Pleural mesothelioma
58
Benzene causes
Acute leukemia
| Hodgkin
59
Be used in
Space industry
60
Be causes
Bronchogenic ca
61
Cadmium causes
Prostate ca
| Lung ca
62
Cyclophosphamide causes
Tcc of ub
63
Diethylstilbesterol causes
Clear cell ca of vagina/cervix in daughters
64
Aniline dyes cause
Tcc of ub
65
Ni causes
Bronchog ca
| Nasal cavity ca
66
Polycyclic HC causes
Scc of skin, oral cavity, esoph, lung, larynx
Adenoca of distal esoph, pancr, kidney
Tcc of ub, renal pelvis
67
Carcinogen for chimney sweepers
Polycyclic HC
68
Polyvinyl chloride causes
Liver angiosa
69
Radon and decay prod cause
Bronchogenic ca
70
Silica causes
Bronchog ca
71
Carcinogen in printing ink, varnish, carpet, paint, leather
Azo dye
72
Carcinogen in light oil, printing, dry cleaning, paint, adhesives
Benzenes
73
Carcinogen in space industry
Beryllium
74
Carcinogen in ore smelting
Cadmium
75
Carcinogen in rubber, chemicals, leather
Aniline dyes
| Aromatic amines
76
Carcinogen in plating, welding, ceamics, batteries
Nickel
77
Carcinogen in charboiled fish/meat
Polycyclic HC
78
Carcinogen in plastics
Polyvinyl chloride
79
Carcinogen in sandblasting
Silica
80
Hhv-8 causes
Kaposi sa in aids
81
Axn of hpv16
E6 gene- inhib p53
82
Axn of hpv 18
E7 gene - inhib rb1
83
Schistosoma haematobium causes
Scc of ub
84
Clonorchis sinensis causes
Cholangioca of bd
85
Opistorchis viverrini causes
Cholangioca of bd
86
Axn of ionizing radn
Hydroxyl fr injury to dna
87
Axn of uvb
Pyrimidene dimers of dna
88
Mc ca in radiologists
Aml/cml
89
Mc ca if thorium dioxide used to visualize art tree
Liver angioSa
90
Most effective host defense against ca cells
Cmi- type iv
91
Cachectic agents
Proteolysis inducing factor
| Lipolysis inducing f
92
Mc an of malign
Acd - an of chr disease
93
An in malign lymphoma
Cold ai hemolytic an
94
An due to mets in bone
Myelophthisic an
95
Teardrop rbcs indic of
Fibrosis in bm
96
Bac responsible for F in ca
E colo
| Pseud aer
97
Cushing syndr as pns in
Small cc
Med ca of t
Pancr ca
98
Gynecomastia as pns in
Chorioca in testis
| Seminoma
99
Hca as pns in
```
Rcc
Scc of lung
Brst ca
Adult t cell leukemia
Malign lymphoma
```
100
hca as pns in
Med ca of t
101
hg as pns in
Hcc
Ovarian ca
Fibrosa
102
hnatremia as pns in
Small cc
103
Sec polycythemia as pns in
Rcc
Hcc
Cerebellar hemangioma
104
Stain to detect epith tissue
Cytokeratin
105
Stain used to detect conn tissue
Vimentin
106
Cd45 positive suggests
Malign lymphoma
107
Afp pos in
Hcc
Yolk sac tumors
Open neural tube defects
108
Bence jones pr pos in
Mm
| Waldenstrim macroglobulinemia
109
Ca15-3 pos in
Brst ca
110
Ca19-9 pos in
Pancr ca
| Colorectal ca
111
Ca125 pos in
Surf derived ovarian ca
112
Cea pos in
```
Colorectal ca
Pancr ca
Lung ca
Stom ca
Heart
```
113
Ldh pos in
Malign lymphoma
114
Neuron sp enolase pos in
Small cc
115
Mc benign tumor of women
Leiomyoma
116
Mc benign tumor of male
Lipoma
117
Precursor for colon ca
Tubular adenoma
118
Apud tumors stain with
S-100 ag
119
Apud tumors
```
Malign melanoma
Small cc of lung
Bronchiocarcinoid
Carcinoid of appendix
Nb of adr medulla
```
120
Mc sa in children
Embryonal rhabdomyosa
121
Mc salivary g tumor
Mixed tumor of parotid
122
Mc extanodal site of primary lymphoma
Stomach
123
2nd Mc extanodal site of primary lymphoma
Peyer's patches in term ilium
124
Mc lymphoma
Follicular b cell lymphoma
125
Tumors of pregn
Trophoblastic
126
Hydatiform mole tumor of
Chorionic villus
127
Vs cont greatest amt of o2 in fetus
Umbilical v
128
Chorioca malign of
Trophoblastic cells
129
Trophoblastic layer secr hormone
Syncytiotrophoblast
130
Hormone secr by syncytiotrophoblast
Hcg
| Hpl
131
Carcinoma which prefers bld route over lymph
Folli ca of thyroid
132
Mc primary ca in brain in adults
Glioblastoma multiforme
133
Mcc of ca in lungs
Breast ca
134
Mcc of ca in ln
Brst/lung ca
135
Mcc of ca in liver
Lung ca
136
Mcc of ca in bone
Brst ca
137
Mcc of ca in brain
Lungca
138
1st site of mets frm testi ca
Paraaortic ln
139
Virchow's nodes receive mets from
Stomach ca
140
Cause of inc Incidence of cns lymphoma
Hiv
141
Mc ca due to uv b radn
Bcc
142
Mcc of mets in adr g
Lung ca
143
Burbik granules on EM indicate
Histiocytic ca
144
Mc ca in hiv
Cns lymphoma
145
Trousseau's sign
Lesions in vs which jump frm 1 site to other- pancr ca
146
Mc cod in ca
Infection
147
Mcc of F in ca
Gram neg inf
148
Mc pns
Hca
149
Lesser Trelat sign
Sudden dev of multi acanthosis nigeicans -
gastric adenoca mc
Insulin R def
MEN syndr
150
Hypertrophic osteoarthropathy is a sign of
Lung ca
151
Mc collagen vs D asso with ca
Dermatomyositis
152
Gottron's patches seen in
Dermatomyositis - knuckles, knees, elbow
153
Marantic endocarditis seen in
Mucus prod ca- colon ca
154
Ca causing Cushing and hyponatremia as pns
Small cc of lung
155
Ca causing cushing and hypocalcemia as pns
Med ca of thyroid
156
Ca causing hypoglycemia and secondary polycythemia as pns
Hcc
157
Tumor markers inc in testi ca
Hcg
| Afp
158
Dec afp in
Down syndr
159
Enz which inc by rectal exam
Prostate acid phosphatase
160
Cea immune complex auses
Diffuse membr glomerulonephritis
161
Mc primary brain tumor in kids
Cerebellar cystic astrocytoma
162
Mc primary ca of brain in kids
Meningioblastoma
163
Only existing tumor vaccine
Hep b
164
Stomach ca in japan due to
Nitrosamines in smoked food
165
Chinese most likely to dev ca due to
Ebv
166
Ca due to ebv
Burkitt
Cns lymphoma in aids
Hodgkin
Np ca
167
Old eastern european with purplish raised lesions on skin
Kaposi sa
168
Cyclin d1 mut causes
Mantle cell lymphoma
169
Transloc in mantle cell lymphoma
T11:14
170
Mutn of cdk4 causes
Melanoma
171
Gfap stains
Neuroglia
172
Chromogranin stains
Neuroendocr cells
173
Ca which prefer hematog spread
Rcc
Hcc
Folli ca of t
Chorioca
