Nervous system drugs

Question 1

inhibition of the electrical conduction down the axon produces _____

Answer 1

anesthesia

Question 2

____ is a general inhalation anesthetic that is very flammable, not used in US

Answer 2

ether

Question 3

____ is a general anesthetic that causes heart arrhythmias and liver damage, not used in US

Answer 3

Chloroform

Question 4

_____ is fluorinated ether, non-flammable and no liver damage

Answer 4

Sevofluorane

Question 5

______ is the neurotransmitter at the ganglia of BOTH sympathetic and parasympathetic nervous systems
bind to ______ receptors at the ganglia
binds to _____ receptors at the post-ganglionic parasympathetic neuron

Answer 5

Acetylcholine
nicotinic
muscarinic

Question 6

drugs that activate post-ganglionic parasympathetic muscarinic receptors are called ______ agonists/antagonists

Answer 6

cholinergic

Question 7

acetylcholine is terminated by _______

Answer 7

acetylcholinesterase

Question 8

______ is the neurotransmitter at the post-ganglionic sympathetic neuron

Answer 8

norepinephrine

Question 9

Norepinephrine is terminated by resorption into the _____ neuron, then eventually inactivated by _______ ____ and ____ _____ _____

Answer 9

afferent
monoamine oxidase (MAO)
catechol orthomethyl transferase (COMT)

Question 10

_____ is a sympathetic neurotransmitter that is released by the _____ _____
inactivated by _______ _____

Answer 10

Epinephrine
adrenal medulla
monoamine oxidase

Question 11

Norepinephrine and epinephrine bind _____ receptors

Answer 11

adrenergic

Question 12

effects of parasympathetic stimulation at Cholinergic receptors:
pupil \_\_\_\_
heart rate \_\_\_\_
broncho-\_\_\_\_\_
bladder \_\_\_\_\_
salivation
erection

Answer 12

constricts
decreases
constriction
voiding

Question 13

effects of sympathetic stimulation at Adrenergic receptors:
pupil \_\_\_\_\_
heart rate \_\_\_\_\_
vaso-\_\_\_\_\_
broncho-\_\_\_\_\_
skin vaso-\_\_\_\_\_
GI vaso-\_\_\_\_\_
ejaculation

Answer 13

dilates
increases
dilation
dilation
constriction
constriction

Question 14

______ acts on all four types of adrenergic receptors

______ acts on all but B2

Answer 14

epinephrine

norepinephrine

Question 15

_____ is a cholinergic agonist that stimulates contraction of detrusor muscle
stimulates _____ post-op or post-partum

Answer 15

Bethanecol

urination

Question 16

_____ inhibitors increase ACh by blocking its inactivation
found in insecticides and nerve gas
can cause muscular and respiratory paralysis

Answer 16

cholinesterase

Question 17

_____ is a cholinergic antagonist used to increase heart rate, and an antidote for poisoning

Answer 17

Atropine

Question 18

the plant ____ _____ is a natural source of Atropine

Answer 18

bella donna

Question 19

_____ _____ is an anticholinergic antagonist given by inhaler for COPD
used in combo with Albuterol to make Combivent

Answer 19

Atrovent

Question 20

_____ is an antispasmodic used to treat nocturia, incontinence
available as patch

Answer 20

oxybutynin

Question 21

newer antispasmodic to compete with oxybutynin: _______

Answer 21

Detrol

Question 22

Norepinephrine and epinephrine have similar ________ structure
rapidly metabolized in ____ and ___ ____
undergo the ____ ____ effect

Answer 22

catecholamine
liver
GI tract
first pass

Question 23

epinephrine given by inhalation

used for anaphylactic shock

Answer 23

Primatene mist

Question 24

_____ is used as a nasal decongestant
cause vaso-_____
now behind the counter because it can be converted into _____

Answer 24

Pseudoephedrine
constriction
methamphetamine

Question 25

many formulas are replacing pseudoephedrine with ______

Answer 25

phenylephrine

Question 26

_____ is the isomer of pseudoephedrine, found in Chinese herb Mahuang

Answer 26

Ephedrine

Question 27

____ and _____ are synthetic versions of epinephrine, now common street drugs injected as crystal or smoked in free base form

Answer 27

Amphetamine | methylamphetamine

Question 28

when meth users hallucinate about bugs crawling on their skin: _____

Answer 28

formication

Question 29

___ and ____ are popular rave drugs, ecstasy | Schedule 1

Answer 29

MDA | MDMA

Question 30

____ is a shrub grown in Yemen that contains ______

Answer 30

Khat | Cathinone

Question 31

____ ____ are synthetic versions of cathinone

Answer 31

bath salts

Question 32

____ is used to treat ADHD | Schedule 2

Answer 32

Ritalin

Question 33

pure enantiomer of Ritalin: _____

Answer 33

Focalin

Question 34

_____ is used for ADHD and is commonly abused | Schedule 2

Answer 34

Adderall

Question 35

_____ was officially approved for treating narcolepsy, shift work sleep disorder , off label for ADHD

Answer 35

Modafinil

Question 36

B1: ___ B2: ___ A1:___

Answer 36

heart lungs skin, etc

Question 37

_____ is a B2 agonist that prevents premature parturition

Answer 37

Terbutaline

Question 38

_____ and ____ are A1 blockers that cause peripheral vaso-____ and are used for BPH which stands for: ____ ____ ____ alternative to TURP which stands for: ____ ____ ____ ____

Answer 38

``` Cardura Flomax dilation benign prostate hypertrophy trans-urethral resection of the prostate ```

Question 39

_____ was one of the first anti-hypertensive drugs, acts on CNS frequently causes depression

Answer 39

Reserpine

Question 40

_____ is used for treating muscle spasms | acts on CNS

Answer 40

Cyclobenzaprine

Question 41

ACh stimulates __-polarization, which stimulates the release of ___ and causes contraction

Answer 41

de | Ca+2

Question 42

neuromuscular blocker _____ binds to ACh receptors and prevents repolarization given IV for surgery AE: sore muscles

Answer 42

Succinylcholine

Question 43

_____ is a neuromuscular blocker that is used on the arrow tips by South American natives not safe for surgery

Answer 43

Tubocurarine

Question 44

______ can be found in patches for smoking cessation called: _____, _____, _____

Answer 44

Nicoderm Habitrol Prostep

Question 45

____ is a partial nictone agonist that has a bad rep from lawsuits about suicide

Answer 45

Chantix

Question 46

____ is a seed/leaf chewed in Southeast Asia stimulates nicotine receptors dark red saliva

Answer 46

Betel