Neuro Flashcards

(230 cards)

1
Q

Treatment of CVA

A

If CT shows ischaemia

Thrombolysis within 4.5 hours
Thrombectomy if within 6 hours with thrombolysis for proximal anterior circulation demonstrated by CTA

If unable to- aspirin 300mg for 2 weeks
If thrombolysis given- aspirin 24 hours after repeat CT

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2
Q

Ix for SAH

A

CT head- non contrast
>12 hrs later- LP for xanthochromia

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3
Q

CI to thrombylysis

A

ABC SHIP
Bleeding- GI bleed in 3 weeks, LP in 7 days
Coagulation problems
Stroke <3 months
Uncontrolled Hypertension- >200
Intracranial neoplasm
Pregnancy

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4
Q

Scoring systems of stroke

A

NIHSS- quantifies severity
ROSIER- differentiate between strokes and mimics

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5
Q

Mx of TIA

A

Aspirin 300mg
Unless taking warfarin, DOAC, bleeding disorder- CT head
Or >7d since sx

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6
Q

When to give carotid endarterectomy

A

When occlusion is >70%

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7
Q

What is total anterior circulation infarct and its symptoms

A

Middle and anterior cerebral

Unilateral hemiparesis +/- hemisensory
Homonymous hemianopia
Cognitive dysfunction

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8
Q

Posterior inferior cerebellar infarct symptoms

A

Lateral medullary syndrome Loss of pain and temp ipsilateral face, loss on contralateral limbs
Ataxia, nystagmus
Can get difficulty swallowing

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9
Q

Anterior inferior cerebellar infarcts

A

Loss of pain and temp ipsilateral face, loss on contralateral limbs
Ipsilateral paralysis and deafness - hearing is AICA over PICA
Ataxia, nystagmus
Can get difficulty swallowing

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10
Q

Vestibular schwannoma symptoms

A

Vertigo, hearing loss, tinnitus
Absent corneal reflex
Associated with NFM 2

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11
Q

Canvernous sinus thrombosis affects

A

Cranial nerves V1+2
3+4+6

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12
Q

What Ix for MG

A

Tenilson test
AchR AB
CXR- thymic hyperplasia

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13
Q

What can cause normal pressure hydrocephalus

A

SAH
Meningitis
Trauma

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14
Q

Types of focal seizures and symptoms

A

Aware and unaware or evolving into generalised typically tonic clonic

Temporal-hallucinations, lip smacking
Frontal- head movements
Occipital- floaters
Parietal- parasthesia

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15
Q

Symptoms of GBS

A

Ascending weakness LMN
After GE or STI

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16
Q

Secondary prevention of CVA

A

Clopidogrel 75mg

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17
Q

Tx of SAH

A

Coiling

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18
Q

Parkinsonism vs parkinsons

A

Parkinsonism- symmetrical, rapid, poor response to levadopa

Parkinsons- asymmetrical, progressive, good response

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19
Q

Parksonism

A

A group of neurological disorders that cause movement problems similar to those seen in Parkinson’s disease such as tremors, slow movement and stiffnes

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20
Q

Parkinson plus syndromes

A

MSA- autonomic dysfunction- postural hypotension, cerebellar ataxia- falls, ED

Vertical gaze palsy- postural instability falls, speech, dementia

CBD- unilateral parks, aphasia, alien limb

Dementia with LB- hallucinations

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21
Q

Tx of Parkinson’s

A

Levadopa with dopa decarboxylase
Co-careldopa

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22
Q

Tx of epilepsy

A

Tonic clonic- valproate, females- lamotrigine or leve

Absence-Ethosuximide

Myoclonic- valproate, female- leve

Tonic/atonic- valproate, female- lamo

Focal- lamo/leve

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23
Q

SE management

A

ABC
Pre-hospital- PR diazepam/buccal midazolam, hospital IV lorazepam
Second dose after 10-20 mins then phenytoin then ICU after 45 mins

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24
Q

CT head immediately guidelines

A

FFS

GCS <13
Vomit >1

Fracture of skull
Focal neurological deficit
Seizure

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25
CT head within 8 hours
LOC/amnesis AND Age >65 Bleeding disorder Cant remember- Retrograde amnesia >30 mins Dangerous MOI
26
Sx of raised ICP
Headache- worse leaning forward Altered GCS- focal neuro Cushing response- high BP, low HR, irregular breathing Papiloedema
27
Horners syndrome
Miosis Ptsosis Anhydrosis
28
Mx of cauda equina
PO dexa Decompressive laminectomy
29
Mx of spinal compression
Dex or surgery
30
Differentials for headache
Tension- tight band, bilateral Cluster- around eye Migraine- aura, throbbing, unilateral Temporal arteritis- jaw claudication Med overuse- worse with meds
31
Types of MND
Amyotrophic Lateral Sclerosis- LMN in arms, UMN in legs Primary Lateral Sclerosis- UMN Progressive Muscular Atrophy- LMN distal before- best prognosis Progressive Bulbar Palsy- palsy of tongue, facial- worst prognosis
32
Causes of tremor
Parkinsons- stiff, resting Essential – worse if outstretched, improved by rest and alcohol, FH CO2 retention- COPD Cerebellar- intention- with nystagmus, past pointing
33
Types of MS
Replase-remitting- acute attacks last 1-2m Primary progressive Secondary progresive- RR to this, gait and bladder too Progressive remitting
34
Sx of MS
TEAM Tingling Eye- optic neuritis Ataxis- other cerebellar- DANISH- dysdiadokinesia, ataxia, nystagmus, intention tremor, slurred speech, hypotonia Motor- spastic Warm temps- make worse
35
Ix of MS
Lp- IgG oligoclonal bands AB- Anti MBP
36
Prognostic signs for MS
Good- female, sensory lesions, <25, long intervals in relapse
37
Mysthenic crisis sx and tx
Reduced RR with MG Ix- ABG Mx- plasmapheresis, IVIG, intubation
38
Ix of MG
Single fibre EMG Anti-AchR
39
Mx of MG
Symptomatic- pyridostigmine after diagnosis Immunosuppress- prednisilone eventually Thymectomy
40
UMN signs
Increased tone Reduced reflexes Reduced power Babinski +ve- upgoing plantars
41
Causes of peripheral neuropathy
Infection Metabolic- DM, sensory predominant , ETOH sensory then motor Autoimmune Vit B12 def
42
Cerebellar vs vestibular nystagmus
Cerebellar- fast phase towards lesion Maximal towards Vestibular- away
43
Causes of Quadranopia
PITS- parietal inferior, temporal superior Parietal superior radiation Temporal- inferior
44
Causes of bitemporall hemianopia
Pituitary- superior Craniopharyngioma- inferior
45
3rd nerve palsy sx
Down and out Ptosis Dilated pupil
46
Wernickes vs Brocas aphasia
Werncikes- receptive Broca- expressive
47
Left posterior inferior cerebral artery Sx
Webers syndrome Contralateral UMN of limbs Ipsilateral CN3
48
Cluster headaches Tx
Oxygen Triptan Prophylaxis- verapamil
49
When do you need a CT for pupil sx
If pupil is unreactive to light and dilated No para- meaning being compressed
50
Mx of acute MS flare up
IM methyprednisilone
51
Medical vs surgical 3rd nerve palsy
Medical- ptsosis and abducted Surgical- dilated due to compression
52
Idiopathic intracranial hypertension sx
Secondary to impaired drainage Causes raised ICP Tinnitus Affects young obese women 6th nerve palsy Papiloedema Change in acuity when changing posture- visual obscuration
53
Blood supply of Wernickes and Broca area
Wernickes- Inferior left MCA- superior temporal gyrus Broca- superior left MCA- inferior frontal gyrus
54
Stroke mx after 4.5 hrs
Aspirin 300mg
55
Amurosis Fugax
Affects retinal/opthalmic artery A temporary loss of vision in one or both eyes due to a lack of blood flow to the retin
56
Degenerative cervical myelopathy sx, dx and mx
Compression of spinal cord in neck Poor coordination Pain in neck loss of sensory and motor Hoffman sign- flick finger, another fingers twitches MRI and surgery urgent
57
Nacolepsy ix
Multiple sleep latency EEG
58
Bells palsy Mx
10 day course of Pred If no improvement after 3weeks- urgent referral to ENT
59
Main Ix of status epilepticus
Rule of hypoxia and hypoglycaemia BM and ABG
60
Neuroleptic malignant syndrome sx
pyrexia muscle rigidity autonomic lability: typical features include hypertension, tachycardia and tachypnoea agitated delirium with confusion Elevated CK Starts soon after starting new AP
61
Where touch and proprioception nerves travel
Dorsal columns
62
Where pain and temp nerves run
Spinothalamic columns
63
Scale that measures how stroke patients cope with ADLS
Barthel index
64
Tx of bells palsy
Prednisilone- 3w follow up- no improvement- ENT
65
Imaging of TIA
Diffuse weighted MR
65
SAH meds
Nimodipine for vasospasm
66
Epidural haemorrhage sx
Injury, lucid, LOC
67
Levadopa SEs
On off effect Postural hypotension Arrythmias Psycosis Red urine
68
When shouldn't you do an LP in meningitis
Sepsis or rash Bleeding risk Raised ICp
69
Tx of brain mets
Dexamethasone
70
Syringomyelia sx
Fluid cavity- Chiari malformation Cape like- neck shoulders, arms - loss of temperature and pain- spinothalamic tract - compression of anterior white commissure Ventral horns- flaccid paralysis
71
Ix of syringomyelia
MRI spine
72
Tx of Parkinsons when NBM
Dopamine agonist patch
73
Pernicious anaemia neuro sc
Peripheral neuropathy- pins and needles Subacute combined degeneration of spinal cord- progressive weakness Psychiatric disorder
74
Sx of Guillain Barre
Ascending Progressive Symmetrical Reflex absent Sensory- mild
75
Normal pressure HC sx
Wide gait- ataxia Urinary symptoms Cognitive impairment
76
Wernickes sx
Altered mental state Ataxic gait Opthalmoplegia
77
Korsakoff sx
Wernickes Plus confabulation and amnesia
78
Causes of vertigo
Viral labrythitis Vestibular neuronitis BPPV Menieres Acoustic neruoma
79
Labrynthitis vs vest neuronitis vs menieres vs BPPV
Recent infection- labry, neuronitis Lab- hearing loss sometimes, not in neuro Menieres- fullness- hearing loss, tinnitus BPPV- short, triggered by head position
80
Parkinson tx that causes personality changes
Dopamine agonist Ropinirole
81
Types of speech disorder
Wernickes- speech fluent, comprehension impaired, repetition imapired Broca- speech broken Conduction- link between 2- speech fluent but repetition is poor Global- affecting all
82
When are you allowed to stop AED
If seizure free for 2 years With AEDs stopped 2-3 months
83
Cerebellar stroke Sx
Ataxia Nystagmus
84
Features of cluster headaches
Last 15 min-2 hours Clusters- 4-12 weeks Lacrimation, redness Nasal stuffiness
85
Factors favouring true seizure over pseudo seizure
Raised prolactin Tongue biting Sudden onset
86
Sx of sinus thrombosis
Headache N+V Reduced consciousness RF of venous thrombosis Gradual onset
87
Ix of sinus thrombosis
MRI venography Usually CT head first
88
Sign for differentiating between organic and nonorganic lower leg weakness
Hoover sign Tell them to press down with weak side- will show no affect Then next flex hip of contralateral (normal) side If weak side extends (you fell it push down) - non organic
89
Medication for spasticity in MS
Baclofen or gabapentin
90
Dx to decrease relapses of MS
Natalizumab
91
Which drugs should be avoided in MG
AB- gentamicin, macrocodes Beta blockers Lithium Phenytoin
92
Dx of young obese female with headache/blurred vision?
Idiopathic intracranial HTN Can cause papiloedema
93
Ix for suspected demyelination
MRI with contrast
94
What should be measured for an alternative diagnosis to TIA
Glucose- hypo can mimic TIA
95
Types of cerebellar lesions
Hemisphere- peripheral ataxia- finger nose Vermis- gait ataxia
96
If someone in public having a stroke, appropriate action?
999- -medical emergency Only give aspirin once haemorrhage ruled out
97
Efferent vs afferent defect in the eye
Efferent- ipsilateral doesn't , opposite eye will react Afferent- consensual reflex will not work
98
Ix for vestibular schwannoma
Audiogram and gadolinium enhanced MRI head- cerebellopontine angle
99
ECG if unresponsive patient with SAH
Torsades pe pointes
100
Tx of stroke vs TIA with AF as the cause
Stroke- Aspirin 300mg 2 weeks then AC TIA- AC immediately
101
Mononeuropathy multiplex vs polyneuropathy
Both peripheral neuropathy Poly-symmetrical Mono- not
102
Causes of injury of median, radial and ulnar nerve
Radial- humeral shaft Supracondyl- ulnar and median less Proximal humerus- axillary
103
Sx of migraine more common in children
GI disturbance
104
Sensory innervation of hand
Ulnar- median side of palm and dorsal Median- lateral side of palm Radial- dorsal side but not finger tops
105
Neuropathic pain tx
Amitriptyline, duloxetine, gaba or pregabalin Switch to another if not working Tramadol used as rescue therapy
106
How long do chronic subdural take to present
4-7 weeks
107
Tx of hydrocephalus
VP shunt
108
Saggital sinus thrombosis sx
Headache, diploma, bilateral papiloedema Empty delta sign on CT venography
109
Cavernous sinus syndrome
Opthalmoplegia Proptosis Periorbital oedema
110
MRC power grade
0- no movement 1- flicker 2- between 3- against gravity 4-between 5- normal
111
Raised ICP symptoms
Cushing triad- irregular breathing, hypertension, bradycardia
112
Damage to lower brachial plexus
Klumpke palsy Lower brachial palsy - forceful abduction or radiotherapy C8-T1 Sensory loss Hand muscle weakness
113
Damage to upper brachial plexus
Erbs palsy Waiter tip sign C5-6 dermatome loss- upper arm
114
Tx of trigeminal neuralgia
Carbmazepine
115
Subacute combined degeneration of the spinal cord
B12 deficiency Presents With sensory and UMN due to dorsal and cortical column degeneration Peripheral neuropathy may be seen as a confounder with it
116
Imaging of brain mets
MRI
117
Inheritance of Charcot Marie tooth
AD
118
Features of Charcot Marie tooth
Starts at puberty Motor Distal wasting Pes cavus- high arch Foot drop, leg weakness Can get some sensory loss too
119
Increase urination with lower homonymous hemianopia
Cranipharyngioma
120
Paroxysmal hemicrania sx and tx
Unilateral severe headache- autonomic features Tx with indomethacin
121
Tx of stroke and TIA with and without AF
Aspirin 300mg daily for 2 week Then AC with AF If TIA start immediately Without- clopidogrel 75mg after 2 weeks
122
Neurofibromatosis vs tuberous sclerosis
Ash leaf spots- hypo pigmented , epilepsy, retinal hamartomas, subungal fibromata - TS Cafe au lait, phaeo, acoustic neuromas- NFM
123
Neuroliptic malignant syndrome fx and tx
Pyrexia Muscle rigidity Raised CK- lead to rhabdo High WCC Bromocriptine
124
Tx of spasticity in MS
Baclofen
125
Tx of pain, urgency and tremor in MS
Pain- amitriptyline Urgency- oxybutynin Tremor- clonazepam
126
Tx of subdural haemorrhage
Acute- decompressive craniectomy Chronic- Burr hole
127
HIV patient with brain lesion- ring enhancing vs homogenous
Homogenous- lymphoma Ring- abscess- toxoplasmosis
128
Tx of idiopathic intracranial HTN
Acetazolamdie
129
Pontine haemorrhage sx
Pin point pupils Quadraplegia
130
If young and had a stroke what ix to do to try identify cause
AI and thrombophilia screen
131
Mx of restless leg syndrome
Dopamine agonist Ropinirole
132
When to start anti epileptic treatment after first seizure
Neuro Deficit Structure abnormality on imagine Epileptic activity EEG
133
If spinal MRI shows several lesions and too frail for surgery
Radiotherapy
134
When can you drive after TIA
1 month free of sx no need to inform DVLA
135
Most important causes of SE to rule out
Hypoxia and hypoglycaemia
136
Jacksonian movememtns
Frontal lobe epilepsy Clonic movements travelling proximally
137
Drug for atonic/tonic seizures female
Lamotrigine
138
Drug for myoclonic seizures females
Levetiracetam
139
Tx of brain abscess
ceftriaxone and metronidazole
140
If high suspicion of spinal cord compression due to bone mets what should you do
MRI and prescribed dexamethasone whilst waiting
141
If ct done <6 hours of sx of SAH show nothing what to do next
Consider alternate diagnosis
142
When does diffuse axonal injury happen
Head rapidly accelerated or decelerated Often no signs
143
If GP and Parkinson's symptoms what do you do
Refer urgently to neuro
144
What medication increases risk of II HTN
Tetracycline Fludrocortisone AMiodaron
145
INO on examination
Affected side abducts Contralateral fails to adduct
146
Eye signs in MS
Red desaturation INO Painful eye with reduced acuity
147
Which medication are ototoxic
Gentamicin Vancomycin Furosemide
148
If CT shows nothing for acute stroke what imaging next
Diffuse weighted MRI- appears bright
149
First seizure driving rules
Inform DVLA do not drive for 6 months
150
Essential tremor Tx
Worse with intention BB
151
Charles bonnet syndrome
Visual loss causing hallucinations
152
Atonic vs tonic falls when having a seizure
Atonic- loss of tension- forwards Tonic- back spasm- backwards
153
Todds paralysis
Paralysed after seizure for 10hrs - 1d
154
SE of phenytoin
Gingival hypertrophy Aplastic anaemai Hypocalaemia
155
SE of lamotrigine
SJS
156
SE of ethosuximide
Night tremors
157
What can intraventricular bleeds cause
Hydrocephalus- reducing GCS
158
Raised ICP ventilation tx
Controlled hyperventilation Reduces CO2 causing vasoconstriction- reducing pressure
159
Nerve affected in herniation
CN 3- down and out
160
4th CN palsy
Weak adduction and depression Eye goes out and up
161
6th nerve palsy
Weak abduction
162
Acute intermittent porphyria px
Abdominal pain Neuro and psych sx
163
MND motor/nerve conduction studies
Normal
164
Tx of bac meningitis >50
Cef and amox
165
Phenytoin SE
Peripheral neuropathy Gum hypertrophy Aplastic anaemia
166
When are triptans CI
In patents with CAD Should avoid SSRI with them- serotonin syndrome
167
Tracts affected in subacute degeneration of spinal cord and sx
Lateral corticospinal tracts - motor - bilateral spastic paresis Dorsal columns - sensory- loss of proprioception, sensory and vibration- start in legs Spinocerebellar - cerebellar - ataxia
168
Tracts affected in Fredriech's ataxia and sx
Lateral corticospinal tracts - motor - bilateral spastic paresis Dorsal columns - sensory- loss of proprioception, sensory and vibration- start in legs High arched palate, per caves, kyphoscoliosis Spinocerebellar - cerebellar - ataxia, intention tremor
169
Anterior spinal artery occlusion
Lateral corticospinal- spastic paresis Lateral spinothalamic- loss of pain and temp bilaterally
170
Loss of corneal reflex nerve damage
V1
171
Mx of MND with lack of eating
PEG
172
Pyridostigmine moa
Long acting ACHe Inhibitor
173
Median nerve motor function
LOAF Lateral lumbicals Opponens, abductor and flexor polices
174
Thoracic outlet syndrome sx
Tingling, muscle wasting Cervical rib
175
Types of MS
Relapse remitting - sx then no sx Primary progressive - gets worse Secondary progressive- RR and progress
176
Miller Fischer variant of GBS
Ophthalmoplegia, areflexia and ataxia Descending paralysis
177
Transverse myelitis sx
Acute Sensory and UMN below MS or infection
178
Coming off opioids and triptans
Wean opioids and stop Tristan abruptly
179
Autonomic dyreflexia sx
Extreme HTN Flushing Sweating above cord lesion Can cause haemorrhage stroke
180
Ulnar nerve muscle innervation
Hypothenar- abductor, flexor digits minimi Adductor pollicis Interossei Medial lumbricals
181
Ix of TIA
BP, ECG, carotid USS< bloods- lipid profile, glucose, clotting
182
Signs on CT of infarct over time
Hyperacute- hyper dense artery, loss of white grey interface Acute- hypodense
183
Painful 3rd nerve palsy cause
Posterior communicating artery rupture
184
What muscles are spared in MND
Ocular
185
Where bleed occurs in subdural haemorrhage
Bridging veins between cortex and venous sinus
186
Headache red flags
Systemic- fever, cancer Neuro signs Onset sudden Onset- thunder Papilloedema
187
Mx of drug induced Parkinson's tremor
Procyclidine
188
What can happen if you stop levodopa abruptly
Can cause acute dystonia
189
What PD medication can cause impulse disorder
Dopamine agonist
190
If clopidogrel not tolerate for stroke
Give aspirin 75mg and modified release dipyridamole
191
Which medications increase mortality in dementia patients
AP
192
How to tx on off effect of levodopa
Increase frequency of it
193
Which sided lesions to cranial nerves cause
Same side as do not cross over Apart from 4th CN
194
Anti emetic for PD
Domperidone
195
Triptan SE
Tight chest Tingling Heat
196
Cause of waddling gait
Weak hips- myopathy Move trunk to move hips LEMS- affects legs first
197
Saturday night palsy
Radial nerve compression Unable to extend wrists
198
Main way to distinguish between levy body and idiopathic PD
Lewy- dementia before motor IPD- motor before
199
Essential tremor sx
Increased with more muscle tone Can affect vocal cords
200
Tx of GBS
IVIG CDIP- chronic- steroids
201
Intercerebral haemorrhage after Ischameic infarct tx
Stop aspirin and BP control
202
CN for corneal reflex and mastication muscle
Trigeminal
203
CN causing vertical diplopia
Trochlear
204
Valproate SE
Vomiting Anorexia Liver toxicity Pancreatitis Retention of weight Oedema Alopecia Teratogenicity, tremor Enzyme inhibitor
205
Which epilepsy is carbmazepine CI in
Myoclonic and absence
206
Most common form of MND
ALS
207
Stroke and allergic to clopidogrel Mx
Aspirin and dipyridamole lifelong
208
Posterior circulation infarcts classification
presents with 1 of the following: 1. cerebellar or brainstem syndromes 2. loss of consciousness 3. isolated homonymous hemianopia- can be macula sparing
209
Isolated high protein in LP
GBS
210
Only cervical nerve root to exit under vertebra
C8 under C7- all others on top All other nerve roots under after
211
Locked in syndrome infarct
Basillar artery
212
AchE side effects
GI- N+V, diarrhoea Fatigue, dizziness
213
Most common cause of amaurosis fugax
Atherosclerosis of internal carotid
214
Brain abcess vs tumour on MRI
Diffuse restricting- abscess
215
Multiple ring enhancing lesions HIV patient with focal neuro signs
Toxoplasmosis
216
Charcot marie tooth vs Fredrichs vs MND presentation
CMT- wasting small hands first, pet vacus, hyperkyphosis Fredrichs- cerebellar MND- fasciculations, no ocular, sensory or cerebellar signs, cramps and spasms
217
Causes of 3rd nerve palsy
Vascular- stroke, CS thrombosis Lesion- malignancy, abscess DM
218
Diplopia when looking down stairs
4th CN palsy
219
Rigidity vs spasticity
Rigidity- not velocity dependent PD Spasticity- velocity- stroke
220
Cause of cerebellar syndrome
MS- days, SOL- years, infection- days, stroke- minutes
221
Types of ataxia
Cerebellar- broad gait, overshoot Sensory- broad, stamping, Romberg +
222
Level spinal cord finishes at
L1-2
223
Driving rules with epilepsy
Must be seizure free for 1 year before getting licence back If withdrawing medication- must not drive for 6 months
224
When to do CT neck immediately
GCS <13 Intubated Clinical suspicion and >65, neuro deficit, high impact or parasthesia
225
What should you avoid with cluster headaches
Alcohol
226
Kernig and Brudsinski sign
Kernig- knee extension causes pain Brudsinski- neck flexion causes knee flexion
227
If had a CT and shows intercerebrayl bleed and patient deteriorates what should you do
Second CT to check for hydrocephalus
228
When to measure phenytoin conc
Before next dose
229
Signs og atonic seizure in face
Eyelid droop or head nodding