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Psychiatry Week 3 > Neurobio of addiction > Flashcards

Flashcards in Neurobio of addiction Deck (8)
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1

What is tolerance to reward?

Due to repeated dopamine release, dopamine receptors down regulate

Threshold for rewards during abstinence is increased

Normal pleasure experiences don't evoke adequate reward response

These persist despite prolonged abstinence.

2

What is the orbito frontal cortex?

Key creator of motivation to act

Addicts have increased activation of OFC when presented with drug cues.

3

Role of the pre frontal cortex?

Helps intention guide behaviour

Modulates powerful effects of the reward pathway

4

What is the function of the striatum and hippocampus?

Striatum- Habit learning

Hippocampus- Declarative learning

5

Which brain areas are responsible for inhibitory control?

Prefrontal cortex and Anterior cingulate gyrus

6

Which brain areas are responsible for motivation/drive?

Orbitofrontal cortex

Subcallosal cortex

7

Which brain area is responsible for memory/learning?

Amygdala

Hippocampus

8

Which brain areas are responsible for reward/salience?

Nucleus accumbens

Ventral pallidum