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Psychiatry Week 3 > Alcohol > Flashcards

Flashcards in Alcohol Deck (17)
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1

What is higher risk drinking?

Regularly consuming over 35 units per week

2

What is increased risk drinking?

Regularly consuming between 15 and 35 units per week

3

What is harmful use of alcohol

A pattern of psychoactive substance use that is causing damage to health (Physical or mental)

4

What is alcohol dependence syndrome?

Strong desire or sense of compulsion to take a drug

Difficulty in controlling use of substance in terms of onset, termination or level of use

5

What is the most common cause of raised MCV?

Alcoholism

6

What is the FRAMES guide

Feedback
Responsibility
Advice
Menu
Empathy
Self efficacy

7

WHen should someone be referred for specialist treatment?

Sign of moderate or severe alcohol dependance

Failure to benefit from brief advice

Show signs of severe alcohol related impariment or comorbidity

8

What is detoxification?

The process by which patients become alcohol free

9

What is relapse prevention?

A combo of psychosocial and pharmacological interventions aimed at maintaining abstinence or problem free drinking following detox

10

Molecular basis of alcohol withdrawal?

Alcohol inhibits excitatory NMDA glutamate ion channels (Chronic use--> Upregulation)

Alcohol potentiates actions of GABA ion channels (Chronic use --> Downregulation)

Withdrawal--> excess glutamate activity and reduced GABA

Excess glutamate toxic to nerve cells

Acute withdrawal leads to CNS excitability and neurotoxicity.

11

Symptoms of alcohol withdrawal?

Restless
Tremor
Sweating
Anxiety
N and V
Insomnia
Loss of appetite

12

Clin signs of withdrawal?

Tachycardia

Systolic hypertension

13

What is delirium tremens?

Following alcohol withdrawal

Confusion, disorientation, agitation, hypertension, fever, visual, auditory hallucinations

14

Management of alcohol withdrawal?

BZD
Vitamin supplementation (Thiamine to protect from Wernicke's encephalopathy)

15

What medications can be given to prevent relapses?

Disulfiram (Antabuse)

Acamprosate

Naltrexone

16

Action of Disulfiram?

Inhibits acetaldehyde dehydrogenase leading to accumulation of acetylaldehyde if alcohol is ingested.

17

Side effects of Disulfiram?

Flushed skin, tachycardia, N+V, arrhythmias and hypotension