Neuromuscular condition 2: Spinal Cord Injury Flashcards
What is spinal cord injury
A complete or incomplete loss of somatic, sensory and autonomic functions below the lesion level
Lesions in the cervical region typically result in
Tetraplegia
Lesions in the thoracic, lumbar and sacral regions lead to
Paraplegia
C4 in the spine is
Artificial support for breathing
C5 - C8 in the spine is
Control of shoulder, elbow and wrist
Decreased hand function
T1 - T6 in the spine is
Autonomic dysreflexia
Poor thermoregulation
Orthostatic hypotension
Diminished breathing capacity
What is Autonomic dysreflexia
An uncoordinated spinally mediated reflex response called the mass reflex
T6 - L2 in the spine is
Respiratory and motor control depends on abdominal muscles
L2 - S2 in the spine is
Lack of voluntary control
Normal upper extremities
Approx how many spinal cord injury possess tetraplegia
How many in men
50%
80% are men
Spinal cord injury of traumatic origin usually occurs at
Early age
Individuals with spinal cord injury have ______ for developing secondary complications
High risk
What causes spinal cord injury
Accidents
Infection
Tumor
What injuries are result of spinal cord injury
Paraplegia
Tetraplegia
Segmental neuromuscular
Autonomic
physiologic impairment
Spinal bifida
Primary injury refers to
Acute spinal cord injury
Such as: Contusion Shear Compression Laceration Stretch
Secondary injury refers to
Systemic injury to neurons and cells nearby
Cellular injury 1
Cellular injury 2
Systemic injury to neurons and cells nearby involves
Hypotension
Hypoxia
Cellular injury 1 involves
Reperfusion of ischemic area
Leads to free radicals
Excitotoxicity
Neuronal malfunction
Death
Cellular injury 2 involves
Neutrophils
Macrophages
Pro inflammatory cytokines
Glial scars
What are the barrier to regeneration and recovery
Cell necrosis
Cell apoptosis
Myelin loss
Oligodendrocyte
Glial scar
Cyst formation
Myelin matrix inhibition
Primary injury acutely leads to
Which then leads to
Also causes
Neuronal damage/disruption
Spinal cord, axon, demyelination and cell death
Also:
Cytokine release
Hemorrhage
Primary injury processed leads to
Inhibitory proteoglycan scar
Limited schwann cell remyelination
Restricted axonal regrowth
What is the cycle of deconditioning
Spinal cord injury
Muscle paralysis
Less physical activity
Lower fitness
Change in body - more fat and less muscle
High risk factors/chronic disease
Causes more of cycle to occurs
Management and medication for spinal cord injury is
Complex due to associated complications
List is on slide 12