New drug approvals 2023 and on

Question 1

Beyfortus

Answer 1

Nirsevimab

Question 2

Nirsevimab indication

Answer 2

RSV prevention from neonates up to 2 years old

Question 3

Zurzuvae

Answer 3

Zuranolone

Question 4

Zuranolone indication

Answer 4

Post partum depression

Question 5

Vyondys 53 indication

Answer 5

Muscular dystrophy amenable to exon 53 skipping

Question 6

Vyondys moa

Answer 6

Increases dystrophin protein in muscle by inducing exon 53 skipping, slowing muscle wasting.

Question 7

Kerendia

Answer 7

Finenerone

Question 8

Kerendia MOA

Answer 8

Aldosterone antagonist

Question 9

Why Kerendia over spironolactone?

Answer 9

Less hyperkalemia

Question 10

Finenerone 2 most common side effects

Answer 10

Hyperkalemia and hypotension

Question 11

Nurtec 3 most common side effects

Answer 11

Abd pain, dyspepsia, nausea

Question 12

Ubrelvy 3 common side effects

Answer 12

Nausea, xerostomia, drowsiness

Question 13

Qulipta indication

Answer 13

Migraine prevention

Question 14

Atogepant 4 common side effects

Answer 14

Weight loss, nausea, constipation, drowsiness

Question 15

Zelsuvmi

Answer 15

Berdazimer

Question 16

Berdazimer indication

Answer 16

Molluscum contagiosum

Question 17

When to use Berdazimer gel

Answer 17

Molluscum lesions on genitals, otherwise it should go away in time

Question 18

Rezdiffra

Answer 18

Resmetirom

Question 19

Resmetirom MOA and indication

Answer 19

non-cirrhotic, non-alcoholic steatohepatitis. Reduces triglycerides in the liver via Thyroid receptor hormone beta agonism (alpha receptors outside liver)

Question 20

5 Most common rezdiffra side effects:

Answer 20

NVD, itching, dizziness

Question 21

Tryvio

Answer 21

Aprocitentan

Question 22

Aprocitentan moa and indication

Answer 22

Endothelin antagonist, HTN add on to other drugs

Question 23

Tryvio boxed warning

Answer 23

Teratogenic

Question 24

Tryvio 2 common side effects

Answer 24

Edema and anemia

Question 25

Duvyzat

Answer 25

Givinostat

Question 26

Duvyzat indication

Answer 26

muscular dystrophy in boys

Question 27

Vafseo

Answer 27

Vadadustat

Question 28

Vafseo indication

Answer 28

Anemia in CKD on 3 months dialysis (limited use)

Question 29

Iqirvo

Answer 29

Elafibranor

Question 30

Elafibranor indication and moa

Answer 30

Biliary cholangitis as add on with ursodiol or alone with intolerance to ursodiol, inhibit bile acid synthesis via PPAR agonism

Question 31

10 common side effects with iqirvo

Answer 31

NVD, weight gain, weight loss, arthralgia, myalgia, GERD, dry mouth, fracture

Question 32

Sofdra

Answer 32

Sofpironium

Question 33

Sofpironium topical indication and MOA

Answer 33

Maxillary hyperhidrosis, inactivates sweat glands

Question 34

Sofpironium 4 common side effects

Answer 34

Dry mouth, blurred vision, urinary retention, application site irritation

Question 35

Voquezna moa and indications

Answer 35

Proton pump inhibitor at potassium channel. Erosive esophagitis treatment and H. Pylori combo

Question 36

Voquezna

Answer 36

Vonoprazan

Question 37

Xanomeline and trospium brand name

Answer 37

Cobenfy

Question 38

Cobenfy indication and MOA

Answer 38

Schizophrenia, M1 and M4 agonist.

Question 39

How is cobenfy different from other antipsychotic’s with BBW’s?

Answer 39

No bw for increased death in elderly with dementia-related psychosis

Question 40

Cobenfy 5 most common side effects

Answer 40

HTN, constipation, heartburn, nausea, and vomiting

Question 41

Amjevita

Answer 41

Adalimumab

Question 42

Abrilada

Answer 42

Adalimumab

Question 43

Cyltezo

Answer 43

Adalimumab

Question 44

Hadlima

Answer 44

Adalimumab

Question 45

Hyrimoz

Answer 45

Adalimumab

Question 46

Idacio

Answer 46

Adalimumab

Question 47

Yuflyma

Answer 47

Adalimumab

Question 48

Yusimry

Answer 48

Adalimumab

Question 49

Pivya

Answer 49

Pivmecillinam

Question 50

Pivmecillinam moa

Answer 50

Beta lactam, acts against penicillin binding protein 2 in gram negative cell walls

Question 51

Pivmecillinam indication

Answer 51

Simple UTI

Question 52

Pivmecillinam dosing

Answer 52

185 mg three times daily for 3 to 7 days, can do 370 mg 3x daily if resistance

Question 53

Pivmecillinam 3 common adr’s

Answer 53

N/V/D, rash, itching, yeast infection

Question 54

Acamprosate moa

Answer 54

GABA modulator, reduces alcohol cravings

Question 55

Acamprosate indication

Answer 55

Alcohol dependence

Question 56

Orlynvah

Answer 56

Sulopenem and probenecid

Question 57

Orlynvah indication and moa

Answer 57

Uncomplicated UTI (women only) in limited or no treatment alternatives. Cell wall inhibition and probenecid increases sulopenem concentrations through renal tubule inhibition of drug clearance.

Question 58

Dose and how to take Orlynvah:

Answer 58

500 mg / 500 mg twice daily with food

Question 59

2 unique side effects with orlynvah

Answer 59

Risk of uric acid kidney stones and exacerbation of gout.

Question 60

Zuranolone 2 common side effects:

Answer 60

Rash and UTI

Question 61

Zuranolone moa:

Answer 61

GABA modulator

Question 62

Rapiblyk

Answer 62

Landiolol

Question 63

Landiolol moa

Answer 63

Beta blocker to rapidly manage supraventricular tachycardia

Question 64

Ensacove

Answer 64

Ensartinib

Question 65

Journavx

Answer 65

Suzetrigine

Question 66

Suzetrigine moa

Answer 66

Peripheral sodium channel inhibitor (prevents pain signals from getting to brain from pain site)

Question 67

Suzetrigine 3 common side effects

Answer 67

Rash, nausea, itching

Question 68

Rezdiffra

Answer 68

Resmetirom

Question 69

Resmetirom

Answer 69

Rezdiffra

Question 70

Resmetirom moa and indication

Answer 70

Hepatic Thyroid hormone receptor partial agonist reducing intrahepatic triglycerides. Indication: NASH with mod to severe liver fibrosis

Question 71

Resmetirom common side effects: 4

Answer 71

N/V/D and itching

Question 72

Vowst indication

Answer 72

Prevent c diff recurrence (filtered poop)

Question 73

Vowst must be given when?

Answer 73

Within 24 hrs of finishing antibiotic

Question 74

How long mounjaro stable at room temp

Answer 74

14 days

Question 75

Ryaltris

Answer 75

Olopatadine and mometasone nasal spray

Question 76

Zoryve

Answer 76

Roflumilast

Question 77

Reyvow

Answer 77

Lasmiditan

Question 78

Lasmiditan

Answer 78

Reyvow

Question 79

Reyvow most common adr

Answer 79

Dizziness

Question 80

Reyvow indication and how often dosed?

Answer 80

Migraine treatment, once daily

Question 81

Blujepa

Answer 81

Gepotidacin

Question 82

Gepotidacin indication and moa

Answer 82

Simple UTI, inhibits bacterial DNA replication (topoisomerase 2 and 4)

Question 83

Gepotidacin dosing

Answer 83

1.5 grams twice daily

Question 84

Weight limit for gepotidacin

Answer 84

Greater than or equal to 40 kg

Question 85

Common side effects gepotidacin

Answer 85

NVD