OCAT #1

Question 1

steroid, slippery

Answer 1

lipophilic

Question 2

gastric mucosa, cardiac muscle, mast cells, brain

Answer 2

H2

Question 3

delivered by the post, can be done for later

Answer 3

packaged

Question 4

acts on other cells

Answer 4

paracrine

Question 5

activation of degranulation occurs

Answer 5

translocation

Question 6

blocks response to receptor

Answer 6

antagonist

Question 7

internal source chemical that calls for response

Answer 7

endogenous

Question 8

enzyme that removes the carboxyl group

Answer 8

decarboxylase

Question 9

VMAT2

Answer 9

Vesicular Monoamine Transporter 2

Question 10

1st messenger introduced to the cell

Answer 10

transduction

Question 11

connective tissue and mucosal, paracrine

Answer 11

mast cell

Question 12

increases secretion of gastric acid

Answer 12

Glands

Question 13

ring structure of histamine

Answer 13

imidazole

Question 14

protein in granule during degranulation

Answer 14

VAMP

Question 15

dendritic cells prevent antigen on membrane to trigger T cells

Answer 15

Contact dependent (need interaction between membrane molecules)

Question 16

prominent in gut for stimulating gastric secretion

Answer 16

Enterochromaffin like (ECL) cells

Question 17

exchanges protons from inside granule for histamine from cytoplasm

Answer 17

VMAT2 / contra transport

Question 18

secretes hormones into the blood stream for long distance

Answer 18

endocrine cell

Question 19

signal is more effective and stable

Answer 19

short distance

Question 20

intracellular signalling pathway

Answer 20

DNA (transcription), RNA (translation), and Protein (enzymes and receptors)

Question 21

sent out from sending cell to target cell

Answer 21

release

Question 22

acts on self, spreads cancer

Answer 22

autocrine

Question 23

promotes vasodilatation, causes edema

Answer 23

Vasculature

Question 24

how ligands binding to receptors bring about an effect to a system

Answer 24

recognition, transduction, response

Question 25

increase in size and loss of granule staining

Answer 25

activated mast cell

Question 26

stops molecule from continuing signalling event

Answer 26

termination

Question 27

pushing system to see what it does

Answer 27

functional

Question 28

degradation termination intracellular

Answer 28

methyltransferase

Question 29

fluorescent tagged antibodies

Answer 29

microscopy

Question 30

specific hormone secreted into blood

Answer 30

neurohormone

Question 31

histamine, noradrenaline, acetylcholine

Answer 31

amine

Question 32

smooth muscle, endothelium, brain

Answer 32

H1

Question 33

external source chemical that calls for response

Answer 33

exogenous

Question 34

lipid bilayers are close and granules can flow out

Answer 34

fusion

Question 35

found in neurons, then in electrical synapse

Answer 35

gap junction (direct cytoplasmic connection)

Question 36

causes release of mediators

Answer 36

degranulation

Question 37

fat cell containing granules in different forms and locations

Answer 37

mast cell

Question 38

allergic conditions

Answer 38

H1

Question 39

image to show the surface structure of a cell

Answer 39

scanning electron microscope

Question 40

initiates physiological response when combine with receptor

Answer 40

agonist

Question 41

type of white blood cell

Answer 41

basophil

Question 42

when detected by target cell it is stimulated

Answer 42

a response

Question 43

converts a form of signal into another

Answer 43

signal transduction

Question 44

gastric acid secretion

Answer 44

H2

Question 45

H2 nobel prize

Answer 45

Black

Question 46

decreases camp

Answer 46

H3

Question 47

corticosteroids, prostaglandins

Answer 47

lipophilic mediators

Question 48

peptide, can not pass through membrane

Answer 48

hydrophilic

Question 49

categorized by distance between signalling and target cells

Answer 49

messenger molecule

Question 50

protein in membrane during degranulation

Answer 50

SNAP

Question 51

pumps protons into granule creating proton motive force

Answer 51

ATPase

Question 52

plasma membrane and vesicle are in close distance, stable complex formed

Answer 52

docking/priming

Question 53

increases camp

Answer 53

H2

Question 54

does not allow for endocrine or neuronal control

Answer 54

Ex-vivo (isolated tissues)

Question 55

image to show the internal structures of a mast cell

Answer 55

transmission electron microscopy

Question 56

Increases IP3, Diacylglycerol (DAG), intracellular Ca

Answer 56

H1

Question 57

toxic form with added carboxyl group

Answer 57

histidine

Question 58

do not express 1 type of histamine receptor

Answer 58

engineered mice

Question 59

activates other molecules in the cell

Answer 59

2nd messenger

Question 60

Decreases cAMP, increases intracellular Ca

Answer 60

H4

Question 61

chemicals secreted by neutrons that diffuse over small gaps

Answer 61

neurotransmitters

Question 62

common over the counter drugs

Answer 62

histamine receptor antagonists

Question 63

Production, Packaging, Release, Response, and Termination

Answer 63

extracellular communication

Question 64

difficult to generalize complex biological conditions

Answer 64

In-vitro (isolated cells)

Question 65

complex disease states (controlled enviro or clinical work)

Answer 65

In-vivo (organisms)

Question 66

H1 nobel prize

Answer 66

Bovet

Question 67

contraction of intestine, bronchioles

Answer 67

Smooth muscle

Question 68

measurement or assessment of structure, quantified property

Answer 68

structural

Question 69

delayed release of mediator in mast cell

Answer 69

leukotrienes

Question 70

degradation termination extracellular

Answer 70

diamine oxidase

Question 71

substance that induces immune response

Answer 71

antigen

Question 72

generic signalling molecule, in demand or in advance

Answer 72

produced

Question 73

increases heart rate

Answer 73

Cardiac muscle

Question 74

multiple cell types can be involved

Answer 74

Ex-vivo (isolated tissues)