OKAPS Flashcards- Cornea Flashcards by Daniel Chao

What disease is associated with Cogan’s syndrome

PAN

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IK and deafness

syphillis

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Where are accessory lacrimal glands

Wolfring- tarsus, Krause- conjunctival fornices

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Enlarged corneal nerves

KCN, refsums’s NF, PPMD, Fuch’s Reiss Bucklers

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Findings in Terrien’s marginal degeneration

high ATR astigmatism in opposite angle of thinning

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Findings of Ehlers Danose

KCN, blue sclera, high myopia

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Which mucopolysaccharidoses are assocaitd with corneal clouding?

All but hunter’s and sanfilipinos

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Causes of corneal verticillatea

amiodarone, antimalariesals, tamoxifen, fabry’s disease

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cause of Fabry’s disease

deficiency of alpha galactosidase

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Histopathology of Salzman’s

replacement of bowman’s with hyaline

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PUK+positive HbsAg

PAN

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Ocular features of PAN

PUK, necrotizing scleritis, secondary Sjorgen’s

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Noninflammatory slowly progressive thinning of peripheral cornea begins superiorly has associated vascular pannus

Terrien’s

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Systemic features of keratconus

Down’s, atopy, marfan’s ehlers danose, MVP

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Which anti-Epstein Barr virus antibody does not peak during first 6-8 weeks?

EBNA

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Corneal clouding in infants

S infectious Trauma - Ulcer-Metabolic Peter’s Dystrophy

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HLA-DR3, tearing, small corneal epithelial lesions

Thygeson’s

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Causes of IK

syphillis, herpes, TB, leprosy, rubeola, EBC, chlamaydia, onchocerca

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systemic association with SLK

Thyroid

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shiledl shaped anterior subcaspular or PSC opacaities

atopic

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staining pattern of RGP lens overwear

3 and 9 o’clock

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where does glucose for corneal epithelium come from

aqueous humor

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which antiviral produces preauricular lymphadenopathy

idoxurine

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hyperkeratotic lesions of palms, elbows,

tyrosinemia type II

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very short person photophobic with polychromatic conjunctival and corneal crystrals

cystinosis

rx for cystinosis

cysteamine

difference between neonatal and adult inclusion conjuncitivitis

follicular response rare in kids

difference in papillae between atopic, vernal and GPC

atopic- papillae in inferior palpebral, VC, GPC in superior tarsus.

avg corneal diameter adult

12.5x11.5, vert by horizontal

acg corneal diameter kid

9.5x10.5

power of cornea

49 front, -6 back

Descemet's membrane

fetal banded anterior, adult nonbanded, thickens with age

assocations with atopic conjunctivitis

KCN, PSC (Maltese cross), HSV keratitis

ddx chronic follicular conjuncitivitis

chlymadia, mediacmentosa, HSV, Lyme, parinaud's, atopic

Adenovirus with pharynconjunctival fever

3,4,5,7. 8,19,37 with epidemic

unilateral follicular conjuncitivitis, penumonitis

Newcastle's occurs in pouletry handlers

HPV viruses associated with CIN

16, 18, actinic exposure

rare variant of squamous cell with malignant goblet cells

Mucoepidermoid, stains with mucicarmine, alcian blue

Seen in halifax, North carolina, bilateral dyskeratotic lesions

benign heriditary intraepithelial dyskeratotis AD

lacrimal and parotid gland swelling and KCS due to sacroid, TB, lymphoma, leukemia

Mikulicz's syndrome

Cogan's syndrome

IK with Menier's like vestibular dysfunciton, 80% progress to deafness without steroids

ddx of keratitis with vestibuloauditory symptoms

syphilis, PAN, Wegner's sarcoid, SO, VKH, cerebellpontine angle tumor.

bilateral, goldben brown deposits

spheroidgal degeneration

corneal mucopolysaccharidoses with retinopathy only

Hunter's, sanfilipo's

Mucopolysaccardigoses with no corneal clouding or retinopathy

Sly's

Mucopolysaccharidoses inheritance

AR except Hunter's, most have corneal clouding, retinopathy, and optic atrophy

Sphingolipidoses inheritance

AR except Fabry's X linked, most affect retina except fabry's

alpha galactosidae deficiency

Fabry's disease

Findings of fabry's disease

corneal verticillata, cataracts, vascular anomalities of heart kidney, brain

ddx of corneal verticillata

amiodarone, chlooroquine, indomethjacin, pheothiazine

HDL deficinecy, relapsing polyneuropathy, deep stromal opacities

Tangier's disease (AR)

diffuse clouding, denser in periphery

fish eye disease

arcus

Hyperlipoporteinemia types 2,3,4

findings of cystinosis

sal and pepper fundus, no visual symptoms, polyuria, retardation, cystine crystals in conj, cornea, iris, lens retina

rx of cystinosis

cysteamine

refractile branching linear opacities, triad of painfu hyperkertotic skin lesions, keratitis, and mental retaration

Tyrosinemia type II ®

young kid with reccurrent HSV keratitis

tyrosinemia type II

corneal melt only in cornea, spreads circumferentially

Mooren's ulcer

what hypersensitivity, and what associations with Mooren's

type II, with hep C, crohn's

painless progressive bilateral stromal thinning starts superiorly

Terrien's

causes of PUK

RA, Wegner's relapsing polychondrisis, PAN, SLE, slceralderma behcet's

organisms which can penetrate cornea

gonorrhea, cornebacterium, shigella, H aegyptis listeria

HSV resides in what ganglion

Gasseiran

immune ring in cornea

type III hypersensitivity

differences between HSV AND HZV dendritie

HZV- no terminal bulbs

fungi

septate- fusarium aspergillus, cuvulaea, nonseptate- mucor

dimorphic fungi

histo, blasto, cocci

book answer for rx for aspergiillus

clotrimazole

recurrence of acanthomeba after PK

30%

rx for microsporida keratitis

fumagillin

antigens for eBV

EBNA, VCA-IgM last for life. Others peak at 6-12 weeks.

KCN histology

breaks in bowman's

associations of eratoglobus

connective tissue disorderes, LCA,

pathology of Map, dot fingerprint

epithelial redublication

Anterior corneal dystrophies

map,dot, fingerprint, messman's, gelatinous, resibuckler's thiel behke

AR corneal dystrophies

macular, gelatinous

difference between reiss buckler's thiel benhke

reiss- curly filaments on EM, thiel- saw toothed epithelium

yellow crystals below bowman's hyperolipidemia

central crystaline schnder's

dystrophy where vision not affected

fleck, tiny wreath like opacitiy

nonprogresive, vision not affected, tiles in the floor

central cloudy of francois, similar to crocodile shagreen

brown mclean syndrome

peripheral corneal decompensation in aphakicpatients central cornea clear

MEN 1

pituitary, parathyroid and pancreas

MEN 2

mdullary thrydoid, peho, parathyroid, can get GI neuromas