oncogenes and their tumors

Question 1

astrocytoma

Answer 1

overexpression of PDGFD - platelet derived growth factor

Question 2

breast carcinomas - subset

Answer 2

amp of ERBB (HER2/ neu) - epidermal growth factor receptor

Question 3

MEN 2A, MEN 2B, and sporadic medullary carcinoma of thyroid

Answer 3

RET point mutation - neural growth factor receptor

Question 4

Gastrointestinal stromal tumor

Answer 4

KIT - point mutation - stem cell growth factor receptor

Question 5

Carcinomas, melanoma and lymphoma

Answer 5

RAS gene family - GTP binding protein - point mutation

Question 6

CML and some ALL

Answer 6

ABL - tyrosine kinase - t(9;22) with BCR

Question 7

Burkitt lymphoma

Answer 7

C-MYC - transcription factor - t(8;14) IgH

Question 8

neuroblastoma

Answer 8

N-MYC - transcription factor amplification

Question 9

Lung carcinoma ( small cell)

Answer 9

L-MYC -transcription factor - amplification

Question 10

mantle cell lymphoma

Answer 10

CCND1 ( cyclic D1) t(11;14) IgH

Question 11

melanoma

Answer 11

CDK4 - cyclin dependent kinase - amplification