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Flashcards in Oncology Deck (17):
1

G1: most _ period of cell cycle. __ act here.

variable; growth factors

2

Radiation therapy: _ phase most sensitive; most effective with __; higher energy = __; path: __; decreased healing due to: __

M phase; high o2 levels; less skin damage; obliterative enarteritis; impaired fibroblasts

3

Extremity sarcoma biopsy: excisional if __; otherwise __; incisional biopsy (less __ disruption-- easier to excise scar if __)

<4cm; longitudinal incision; lymphatic disruption; biopsy positive (Every year)

4

Li Fraumeni syndrome:
_ mutation
_
_ CA
_ tumors
_

p53 mutation; sarcomas, breast ca; brain tumors; leukemia

5

Sarcomas generally spread __; not to __. Staging based on _; not on __

hematogenously, not to lymphatics; based on GRADE not size/nodes

6

Colon Ca associated w:
__
__
__
__

loss of APC gene; p53; DCC; k-ras activation

7

Breast Ca associated w:
_
_
_
_
_

p53; BCL-2; C-myc; C-myb; her 2 neu

8

C- myc associated with:
_
_
_

small cell lung CA; neuroblastoma; burkitt's lymphoma

9

BCL-2 gene regulates __;
__ and __ also associated with this process

apoptosis; p53 and c-myc

10

sis oncogene is homologous to __

PDGF

11

Erb B codes for ___;
associated with __ survival in breast ca

epidermal growth factor receptor; decreased survival

12

K ras __ oncogene encodes for __ protein.
__% of pancreatic ca
_% of colon ca
also in __ ca

proto-oncogene; GTP; 90%, 50%; lung

13

Ret __ oncogene diagnostic for __. Patient with family history of __ who has Ret should have __.

proto-oncogene; Medullary thryoid cancer; MEN; total thyroidectomy

14

Tamoxifen (binds ___) shown to decrease breast cancer in high risk. Risk of __ with endometrial cancer.

estrogen receptor; DVT

15

__ and __ both have pulmonary fibrosis as complication.

Bleomycin and Busulfan

16

__ and __ both cause neurotoxicity.

Vincristine and cisplatin

17

Levamisole mechanism: ____; is an ____ agent.

immunostimulant; antihelminthic