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Flashcards in Oncology Deck (58):
1

Most common site of pathological fracture secondary to boney mets

proximal femur

2

What cell signalling molecule is defective in fibrous dysplasia

G-protein

3

Recurrence of chondrosarcoma is directly related to activity of what

telomerase

4

RB gene

retinobalstoma
osteosarcoma

5

sarcoma, breast cancer oncogene

p53

6

chondrosarcoma, melanoma, osteosarcoma oncogene

p16ink41

7

Colon adenomas, desmoid tumors

APC (familial adenomatous polyposis)

8

NF1

neurofibromas

9

EXT1/EXT2

hereditary exostosis

chondrosarcomas

10

t(11, 22)

Ewing, PNET
EWS, FLI

11

t(X, 18)(p11;p11)

synovial cell
SYT, SSX

12

x(12;22)(p13;a12)

clear cell sarcoma
EWS, AFT1

13

t(2;13)(p35;q14)

rhabdomyosarcoma
PAX3
FKHR

14

t(12;16)(q13;p11)

myxoid liposarcoma

15

Benefit of pre-op rads

higher risk of wound complications
lower risk of fibrosis
lower dose of radiation

16

most common site of oteoid osteoma

proximal femur
(increased prostaglandins)

17

most common benign tumor of the hand

enchondroma

18

pain associated with enchondroma

chondrosarcoma

19

ollier's disease

multiple enchondromas; no genetic inheritance
dysplastic bones with bowing
high risk of metastatic conversion (30%)

20

maffucci's syndrome

multiple enchonromas
associated with angiomas
calcified phleboliths, visceral malignancy
malignant conversion 100%

21

encondroma conversion to chondrosarcoma

50% endosteal scalloping
> 5cm (larger size)

22

chondroblastoma characteristics

like GCT, physeal
occur with ABC, consider clear cell chondrosarcoma
need to CT chest (treat mets with surgery)
intralesional curettage with bone graft
phenol as an adjunct, 10% recurrence

23

Risk of using liquid nitrogen as an adjunct

stress fracture

24

FGF-R3

fibrous dysplasia
may be present with mcune-albright or oncogenic osteomalacia

25

mcCune-Albright

polyostotic fibrous dysplasia (unilateral)
coast of maine - cafe au lait
precocious puberty

26

Mazabraud syndrome

fibrous dysplasia
intramuscular myxomas

27

Jaffe-capanccini syndrome

NOF
metal retardation
cafe au lati
heart, eyes, gonads

28

vertebral planae

eosinophilic granuloma

29

treatment of EG

isolated - injection methylprednisolone acetate
Curettage if biopsy necessary
vertebral planae - treat with brace
disseminated disease - chemo (bad prognosis with visceral invovlement)

30

Fluid-fluid levels on MRI

ABC

DDx
GCT
telangectatic osteosarcoma

31

ABC treatment

intralesional curettage and bone graft
phenol
embolization of spinal or pelvic lesions

32

UBC treatment

allow fracture to heal
methylprednisolone injection
intralesional curettage with bone graft/fixation

33

when can you use embolization for GCT

pelvic, spinal lesions
pre-operatively

34

What do you need to consider in work-up for GCT

mets to lungs

35

most important prognostic indicator of osteosarc

tumor stage

36

risk of recurrence following osteosarc resection

5%

37

5 year survival of osteosarc

70%

mets or pelvis - 20%

38

treatment of parosteal osteosarcoma

wide resection
most common location behind the knee

39

pariosteal osteosarcoma treatment

chemo with wide resection
usually on the diphysis - sunburst

40

CD99

Ewing sarcoma

41

posterior elements spine tumors

osteoid osteoma
osteoblastoma
ABC

42

Factors associated with risk of post-radiation fracture

female
>50
higher dose (>60)
periosteal reaction

43

How to assess maturity of HO

radiographs

bone scan will still be positive
may take longer than 12 months

44

Common radiation doses

HO - 6G
Mets - 30G
Soft tissue sarcoma - 60G

45

Most common tumour found in the foot

synovial cell

46

clinical appearance of angiosarcoma

often occurs in the hand
destructive lytic lesions with vascular invasion
CD31 is a sensitive marker

47

CD31

angiosarcoma

48

what are the urinary markers of pagets

Increased urinary N-telopeptide and alpha-C-telopeptide

49

S100

nerve cell tumor
melanoma
clear cell sarcoma

50

where does HO develop after amputation

when amputation occurs at the level of amputation
increased with blast

51

prefered fixation for osteotomy in pagentoid bone

metaphyseal
plate fixation

52

Fibrodysplasia Ossificans Progressive

Rare, stone man disease
ACVR1 gene

53

ACVRI gene

fibrodysplasia ossficians progressiva

Progressive HO (muscles, fascia, tendons, joints)
Great toe dysplasia
BMP4 is abnormal in this disease

54

chemo

Osteosarcoma
Ewings
synovial sarcoma
dediff chondro
mesenchymal chondro

55

CD31

angiosarcoma

aggressive, lytic lesions
associated with polyvinyl chloride

56

CD20 and CD45

lymphoma

57

development of HO following knee dislocation is correlated to

ISS

58

intramuscular myxoma treatment

wide resection